Objective The encephalic entropy index (M-Etronpy) was used as an indicator of anesthesia sedation depth to investigate the effect of two doses of remifentanil on the concentration of effect compartment and the depth of anesthesia during propofol-controlled infusion. Methods A total of 81 patients requiring general anesthesia were divided into A, B and C groups (n=27) according to different target concentrations of remifentanil.Group A received 0.9% sodium chloride injection for anesthesia induction and maintenance, group B received 2 ng·mL-1 remifentanil, group C was subjected to 4 ng·mL-1remifentanil for anesthesia induction and post-intubation 3 ng·mL-1 remifentanil for anesthesia maintenance.The level of sedation was assessed using OAA/S by the anaesthesiologist.The HR, MAP, SpO2, BIS values, SE, RE, and propofol effector chamber concentrations at different time points were recorded. Results Compared with group A, the concentrations of propofol in the group B and C were significantly decreased from t1 to t5 (P<0.05).At t6, the propofol effector concentration in group C was significantly lower than that in group A (P<0.05).The correlation coefficient between SE (r=0.84) and RE (r=0.85) and propofol effector chamber concentrations were similar.SE and RE decreased in all groups with decreasing OAA/S scores.Remifentanil infusion, in a concentration-dependent matter, resulted in higher values for SE and RE at LVC and LRP. Conclusion Induction and maintenance of anesthesia with remifentanil can reduce effector chamber concentration and propofol dosage during propofol target-controlled infusion induction, SE and RE to predict OAA/S, LVC and LRP are accurate.
刘龙娟,孔重红. 不同剂量瑞芬太尼对丙泊酚靶控输注诱导期效应室浓度和麻醉深度的影响[J]. 医药导报, 2019, 38(6): 742-746.
Longjuan LIU,Zhonghong KONG. Effect of Different Doses of Remifentanil on the Concentration of Effect Compartment and the Depth of Anesthesia in the Induction Period of Propofol Target Infusion. Herald of Medicine, 2019, 38(6): 742-746.
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