Progress of the Influence of Traditional Chinese Medicine Injections on Warfarin Anticoagulation Effect and Related Mechanisms
Yan QIAO1(),Mengnan QIN1,Xinglei GUO2,Gaofeng LIU1()
1.Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, Key Laboratory of University in Heilongjiang Province, Harbin 150086, China 2. Women and Children Hospital of Qingdao City, Shandong Province, Qingdao 266034, China
Up to now, the results showed that some traditional Chinese medicine injections such as Salvia miltiorrhiza injection, Acanthopanax injection, Xueshuantong injection, Danhong injection, Shuxuetong injection and Safflower injection could enhance the anticoagulant effect of warfarin. The mechanisms include pharmacokinetic interactions such as influence on plasma protein binding of warfarin, inhibiting or inducing activities of warfarin-related cytochrome P450 metabolic enzymes, and pharmacodynamic influence. Some traditional Chinese medicine injections have a bleeding risk in combination with warfarin. Clinical studies have also shown that the use of synergistic anticoagulant effects in the treatment of certain thromboembolic diseases can have a beneficial effect on treatment, but there is still no evidence-based research and evaluation. Therefore, attention should be paid to the possible influence of traditional Chinese medicine injections on warfarin anticoagulation in clinic, and INR needs to be monitored closely for the patients, or adjust warfarin dosage appropriately, or avoid the combined use of the two kinds of drugs with mutual effects, so as to ensure safety of patient.
乔艳,秦梦楠,郭兴蕾,刘高峰. 中药注射剂对华法林抗凝作用的影响及相关机制的研究进展*[J]. 医药导报, 2019, 38(6): 765-769.
Yan QIAO,Mengnan QIN,Xinglei GUO,Gaofeng LIU. Progress of the Influence of Traditional Chinese Medicine Injections on Warfarin Anticoagulation Effect and Related Mechanisms. Herald of Medicine, 2019, 38(6): 765-769.
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