1.Department of TCMs Pharmaceuticals, China Pharmaceutical University , Nanjing 211198, China 2.Center for Certification and Evaluation, Guangdong Food and Drug Administration, Guangzhou 510080,China 3.Shandong Institute for Food and Drug Control, Jinan 250101,China 4.Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009 ,China
Objective To investigate the solubilization effects of mogroside V as a novel carrier on the poorly soluble drugs. Methods Using mogroside V as a carrier and paclitaxel as a model drug, a solid dispersion of paclitaxel-mogroside V was prepared by the solvent method.The content of paclitaxel was determined by high performance liquid chromatography (HPLC). The saturated solubility and in vitro dissolution of paclitaxel were investigated.In addition, differential thermal scanning (DSC) was used for phase identification and evaluation of drug crystal changes in solid dispersion . Results Paclitaxel-mogroside V solid dispersion showed pronounced improvement in both dissolution rate and drug solubility, as evidenced by a 375-fold increase in solubility compared with paclitaxel.The results of DSC indicated that paclitaxel was in amorphous form in solid dispersion. Conclusion Mogroside V can improve the solubility and in vitro dissolution of the poorly soluble drug.Being safe and non-toxic, mogroside V was found to have suitable characteristics to be used as a pharmaceutical excipient.
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