Objective To prepare galactosylated bovine serum albumin nanoparticles (Gal-BSA NPs) of curcumin by desolvation method, and to investigate its physicochemical properties and in vitro release characteristics. Methods Gal-BSA NPs were prepared by emulsion solvent evaporation method, and the preparation processes was optimized. Its size and Zeta potential were measured by Laser size and Zeta potential instrument. Entrapment efficiency and drug loading were measured by ultracentrifugation. The in vitro release characteristics were investigated by dialysis method. Results According to the preparation of the formulation and process optimization, the appearance of Gal-BSA NPs prove to be round or oval, particle size distribution was (267.1±78.3) nm, Zeta potential was -40 to -50 mV. Entrapment efficiency was 79.4%, and drug loading was 3.7%. Gal-BSA NPs release 20% at 8 h and >80% at 48 h. Conclusion Solvent evaporation method can successfully prepare Gal-BSA NPs, and shows good physical and chemical properties and release properties, improve the stability of the drug, and can prolong the drug release rate and improve the bioavailability.
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