Abstract：ObjectiveTo provide evidence for clinical trial and to evaluate the safety of total flavonoids from rhizome of drynariae MethodsThe maximum tolerance of gastrogavage in mice: twenty mice were fed 30 mL·kg-1 with the total flavonoids solution (0.40 g·mL-1 ) by gastrogavage， the bite and sup， activity， psychosis， coat and skin， urine and faeces， and body weight were observed The maximum tolerance of gastrogavage in rats: twenty rats were given the same dose total flavonoids solution， and the same observation were done The acute toxicity trial in mice, LD50 was carried out by abdominal injection with 7 dosage groups， and the mice were observed for 7 days after one injection ResultsThe mice and rats had no abnormal changes in bite and sup， activity， psychosis， coat and skin， urine and faeces， and body weight There were no significant changes(P＞0.05) Only a little remain of the fed sample was found in the abdomen anatomizing And there were no remarkable pathological changes in all organs The median lethal dose of the total flavonoids was 5.99 g·kg-1 ConclusionThere are no abnormal changes in the acute toxicity trial with total flavonoids from rhizome of drynariae, and the flavonoids are safe in clinical use
赵晋宁;谢雁鸣;张文军;王智;刘玉琦. 骨碎补总黄酮急性毒性实验[J]. , 2005, 24(1): 0-0.
ZHAO Jinning;XIE Yanming;ZHANG Wenjun;WANG Zhi;LIU Yuqi. Acute Toxicity Test of Total Flavoids from Rhizome of Drynariae. , 2005, 24(1): 0-0.