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  2005, Vol. 24 Issue (1): 0-0    
  药物研究 本期目录 | 过刊浏览 | 高级检索 |
骨碎补总黄酮急性毒性实验
赵晋宁;谢雁鸣;张文军;王智;刘玉琦
中国中医研究院西苑医院实验动物中心,北京100091
Acute Toxicity Test of Total Flavoids from Rhizome of Drynariae
ZHAO Jinning;XIE Yanming;ZHANG Wenjun;WANG Zhi;LIU Yuqi
Xiyuan Hospital, Academy of Traditional Chinese Medicine, Beijing 100091, China
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摘要 目的评价骨碎补总黄酮的安全性,给临床实验提供依据,从而保证临床用药安全。方法①小鼠灌胃最大耐受量测定:20只NIH小鼠给予0.40 g·mL-1骨碎补总黄酮溶液30 mL·kg-1,分2 次(8∶30,16∶30)灌胃给药,观察其饮食、活动、精神状态、皮毛肤色、大小便及体重变化。②大鼠灌胃最大耐受量测定:20只Wistar大鼠灌胃给予0.40 g·mL-1骨碎补总黄酮溶液30 mL·kg-1,分2次(8∶30,16∶30)给药,观察其饮食、活动、精神状态、皮毛肤色、体重、摄食量变化及大小便。③小鼠腹腔注射给药急性毒性实验(LD50):设置7个浓度的药液进行腹腔注射,一次给药后观察7 d。结果小鼠、大鼠灌胃给药后,其饮食、活动、精神状态等体征均无异常变化,体重变化在正常范围内(P>0.05)。小鼠急性毒性实验,尸检可见动物腹腔内有少量残留药液,重要脏器未见明显病理变化,总黄酮LD50=599 g·kg-1。结论骨碎补总黄酮急性毒性实验未显示毒性作用,预期临床应用安全性良好。
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关键词 骨碎补总黄酮毒性实验急性最大耐受量半数致死量    
AbstractObjectiveTo provide evidence for clinical trial and to evaluate the safety of total flavonoids from rhizome of drynariae MethodsThe maximum tolerance of gastrogavage in mice: twenty mice were fed 30 mL·kg-1 with the total flavonoids solution (0.40 g·mL-1 ) by gastrogavage, the bite and sup, activity, psychosis, coat and skin, urine and faeces, and body weight were observed The maximum tolerance of gastrogavage in rats: twenty rats were given the same dose total flavonoids solution, and the same observation were done The acute toxicity trial in mice, LD50 was carried out by abdominal injection with 7 dosage groups, and the mice were observed for 7 days after one injection ResultsThe mice and rats had no abnormal changes in bite and sup, activity, psychosis, coat and skin, urine and faeces, and body weight There were no significant changes(P>0.05) Only a little remain of the fed sample was found in the abdomen anatomizing And there were no remarkable pathological changes in all organs The median lethal dose of the total flavonoids was 5.99 g·kg-1 ConclusionThere are no abnormal changes in the acute toxicity trial with total flavonoids from rhizome of drynariae, and the flavonoids are safe in clinical use
收稿日期: 1900-01-01      出版日期: 2005-01-01
引用本文:   
赵晋宁;谢雁鸣;张文军;王智;刘玉琦. 骨碎补总黄酮急性毒性实验[J]. , 2005, 24(1): 0-0.
ZHAO Jinning;XIE Yanming;ZHANG Wenjun;WANG Zhi;LIU Yuqi. Acute Toxicity Test of Total Flavoids from Rhizome of Drynariae. , 2005, 24(1): 0-0.
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