中国科技论文统计源期刊 中文核心期刊
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
ABSTRACT Objective To establish a method for the determination of hesperidin and cinnamaldehyde in siweiqing buccal tablets.Methods A high performance liquid chromatography (HPLC) method was established.The chromatographic conditions were as follows: the chromatographic column Inertsil ODS-SP(4.6 mm×150 mm,5 μm) with the mixture of acetonitrile and water as mobile phase in gradient mode,the detection wavelength of 290 nm,the flow rate of 1.0 mL•min-1,the column temperature of 30 ℃,the theoretical plate number no less than 3 000.Results The linear relationship between content and peak area was obtained in the range of 0.025-0.500 μg for cinnamaldehyde and 0.10-2.00 μg for hesperidin.RSD of the peak area of cinnamaldehyde and hesperidin for the precision test,the stability test and the repeatability test were 1.16%and 1.03%,1.27%and 1.08%,1.23%and 1.28%,respectively.The average recovery of cinnamaldehyde was 99.24%with RSD of 1.65%(n＝9).The average recovery of hesperidin was 99.39%with RSD of 1.85%(n＝9).Conclusion The method can be applied to quantitative assay of cinnamaldehyde and hesperidin in siweiqing buccal tablets with good reproducibility and specificity.The recovery result met the acceptance criteria.The method can effectively control the quality of siweiqing buccal tablets with good specificity,reproducibility and stability,and can be applied to the quality control of siweiqing buccal tablets.
