药物研究
HUANG Min;RAO Wei-yuan;WANG Li
Objective To study the antiinflammatory and antibacterial effect of paozhen bingdu tablet.Methods Mice were divided into 5 groups randomly: normal saline group, positive group, high, middle and low dose groups of paozhen bingdu tablet(10.2, 6.8, 3.4 g.kg-1, respectively).The antiinflammatory effect of paozhen bingdu tablet was observed via mouse earswelling model and cotton pellet induced granuloma and paw edema model, and by using mouse peritoneal capillary oozing test.The antibacterial effect of paozhen bingdu tablet was observed through in vitro and in vivo antibacterial test.Results The high dose of paozhen bingdu tablet significantly relieved earswelling, inhibited peritoneal capillary oozing, and reduced paw edema degree and cotton granuloma weight(P＜0.05).Paozhen bingdu tablet had in vitro antibacterial effects on Staphylococcus aureus, Staphylococcus epidermidis, Shigella dysentery bacillus, Acinetobacter, Enterococcus, Pseudomonas aeruginosa, E.coli, Shigella flexneri, Klebsiella pneumoniae, Enterobacter cloacae, Candida albicans, B Streptococcus, and Pulmonary Streptococcus.The minimum inhibitory concentration(MIC) was 1.00, 1.00, 4.00, 4.00, 4.00, 4.00, 4.00, 4.00, 4.00, 4.00, 4.00, 4.00, 4.00 g.mL-1, respectively.Paozhen bingdu tablet reduced mortality in mice infected with Staphylococcus aureus and Staphylococcus epidermidis.Conclusion Paozhen bingdu tablet has anti inflammatory and antibacterial effects.
