妇产科用药专栏
ZHANG Dandan;CHEN Juanjuan;FANG Jianguo;WAN Jin;WANG Nan;CHEN Suhua
ABSTRACTObjectiveTo study the in vitro anticytomegalovirus effect and the security of andrographis paniculata. MethodsThe 0% toxic dose (TD0), minimum effective concentration (MEC) and therapeutic index (TI) of anticytomegalovirus activity by andrographis paniculata were detected with cytopathic assay and MTT method, and compared with those of ganciclovir, honeysuckle, houttuynia cordata and folium isatidis. ResultsThe TD0 of ganciclovir, honeysuckle, houttuynia cordata,folium Isatidis and andrographis paniculata were 10,3 000,30 000,30 000,3 000 μg8226;mL1, the MEC were 10,3 000,3 000,3 000,300 μg8226;mL1, TI were 1,1,10,10 and 10, respectively. ConclusionsAndrographis paniculata showed a good in vitro anti cytomegalovirus effect, which is higher than honeysuckle, houttuynia cordata and folium isatidis, and a equivalent cytotoxicity to honeysuckle but higher than houttuynia cordata and folium isatidis. The TI of andrographis paniculata is higher than honeysuckle but equivalent to houttuynia cordata and folium isatidis. Therefore, andrographis paniculata has the potential advantages for clinical use and worth further study.