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    特约稿
  • 特约稿
    Evaluation Mode of Prescribing Drugs in Hospital
    WU Xiao-ling;XIE Yi-dan
    2010, 29(1): 1-4. https://doi.org/10.3870/yydb.2010.01.001
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    ABSTRACTObjectiveTo explore the evaluatioin mode of hosipital drug prescribing according with our national conditions. MethodsThree roles were established to form a systematic institution of evaluating drug prescription by setting up specific executing agencies, improving work systems and process specification, establishing clinical pharmacists system, quality control and evaluation system for drug rational use. ResultsA highly effective prescription appraisal mode was established in the hospital, which achieved remarkable results in promoting doctors’ rational use of medicines, reducing the burden of medical costs in patients and ensuring sustained and healthy development of the hospital. ConclusionThe model can maximally take the initiative intervening the doctors’ unreasonable use of medicines, effectively reduce the medication defects and medical disputes, improve the rational use of drugs in hospitals, control the medicines’ proportion, outpatient prescription costs and hospital charge, and continuously improve the hospital’s social benefits.
    • 药物研究
  • 药物研究
    Regulation Effects of Antiarrhythmic Drug E4031 on Tumor Biologic Behavior of Gastric Cancer Cell Line SGC7901
    LV Qing;LU Xiaoming;SHU Xiaogang;SUN Renhu;CUI Jing;WANG Guobin
    2010, 29(1): 5-9. https://doi.org/10.3870/yydb.2010.01.002
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    ABSTRACTObjectiveTo investigate the regulation effects of the class Ⅲ antiarrhythmic drug E4031, HERG K+ channels specific blocker on herg1 gene expressed in gastric carcinoma cell line SGC7901, and explore whether it could prevent tumorigenesis of gastric carcinoma. MethodsReverse Transcription PCR assay and westernblot analysis were used to detect the expression of herg1 gene on cell line SGC7901. By blocking the channels with the class Ⅲ antiarrhythmic drug E4031, the tumor cell invasion, proliferation and apoptosis were analyzed. ResultsThe herg1 gene was over expressed in the gastric cancer cells. While, the cell population at G0/G1 phase and apoptotic number of tumor cells were increased(P＜0.01), and less tumor cell proliferated was found when HERG K+ channel was blocked by E4031 (P＜0.05). Moreover, the drug inhibited cell migration (P＜0.05). ConclusionHERG K+ channels were probably overexpressed in the gastric cancer cell line SGC7901 and the class Ⅲ antiarrhythmic drug E4031 could make a important role in regulating the biological behavior of tumor cells and suppressing the growth of tumor.
  • 药物研究
    Effect of Triptolide on Secretion of Inflammatory Cellular Factor NO and IL6 in Mice Peritoneal Macrophage Activated by Lipopolysaccharide
    YANG Fan;BAI Xiangjun;LIU Kaijun;YANG Yejin;ZENG Ye
    2010, 29(1): 9-12. https://doi.org/10.3870/yydb.2010.01.003
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    （1.Department of Traumotic Surgery Affiliated with Tongji Hospital,2.Department of Biochemistry and Molecular Biology,Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030,China）ABSTRACTObjectiveTo study the effect of triptolide（TP） on NO and IL6 of peritoneal elicited macrophage（MΦ） activated by lipopolysaccharide（LPS） in mice. MethodsThe peritoneal elicited macrophage were separated,purified and activated by LPS in mice,then cultured in vitro with a series concentration of TP.The activity of NO and level of IL6 in cellular supernatants were determined by Griess reagent and ELISA,respectively. ResultsThe activity of NO in MΦ was significantly inhibited（P＜0.01） by TP（0.01－10.00 μg•mL1） during 4－24 h in a time and dosage dependent manner;The level of IL6 was obviously decreased（P＜0.01） by TP（0.001－10.000 μg•mL1） in 12 h in a dosedependent way.ConclusionTP could inhibit the NO activity and IL6 level in macrophage activated by LPS,and it has strong antiinflammatory effects with low toxicity.
  • 药物研究
    The Protective Effects of Huxinling on Experimental Acute Myocardial Infarction in Dogs
    LI Mingchun;LI Xiuzhong;XU Jiangping
    2010, 29(1): 12-15. https://doi.org/10.3870/yydb.2010.01.004
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    ABSTRACTObjectiveTo investigate the protective effects of huxinling on experimental acute myocardial infarction （AMI） induced by ligation of anterior descending coronary artery in anaesthetized dogs.MethodsThe model of acute myocardial infarction was established by ligating left arterial descending artery in dogs.The severity of myocardial ischemia and infarction area were measured. ResultsIt was found that huxinling increased the myocardium ventilation, attenuated the degree and scale of myocardial ischemia,and decreased the infarction size of dogs. ConclusionCompound huxinling possesses the protective effects on acute myocardial infarction.
  • 药物研究
    Effect of Yinbaitang nButanol Extract on Reducing Enzyme and Receding Jaundice in a Mice Jaundice Model Induced by ANIT
    WU Yiyan;LEI Tao;YANG Zhi;MENG Fanqin;HOU Jiafu;LIU Guangqin
    2010, 29(1): 16-18. https://doi.org/10.3870/yydb.2010.01.005
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    ABSTRACTObjectiveTo investigate the action of the nbutanol extract from Capillary Wormwood Herb,Rhizoma imperatae,Radix Lithospermi Root of Sinkiang Arnebia and so forth on reducing enzyme and receding jaundice in a jaundice model of mice induced by αisothiocyanate （ANIT）.MethodsMice were randomly divided into six groups: group A as normal control, group B as model control, group D,E, F treated with low,moderate and high dosage of “EXTRAC”,respectively, and group E was given with“ yinzhihuang injection” as positive control.Mice were p.o.treated for consecutively 7 d,except group A and B, then were given with ANIT to induce jaundice.After 48 h, the blood was withdrawn and serum was separated.The serum content of ALT、AST and ALP and pathological changes of liver tissue were observed.ResultsCompared with group B, ALT, AST, ALP,TBiL,IBiL in group C and D group obviously dropped （P＜0.05） ; Compared with group C,those in group D group did not change significantly （P＞0.05）; It was found that “Extract” at a middle and high dose notably alleviated liver cell degeneration,necrosis and bile duct proliferation.Conclusion“Extrac” has the action of reducing serum bilirubin and transaminase and improving liver tissue injury of experimental cholestasis in mice.
  • 药物研究
    Curative Effect of Vitiligo Gel on Experimental Vitiligo Models
    JIANG Tao;GE Qin;ZHANG Enjuan;ZHOU Yongde
    2010, 29(1): 19-21. https://doi.org/10.3870/yydb.2010.01.006
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    ABSTRACTObjectiveTo study the curative effect of vitiligo gel on experimental guinea pig models of vitiligo.MethodsThe animal models of vitiligo were prepared by chemical decolour method,then treated with vitiligo gel and tincture as control.AMMC, activity of acetylcholine esterase and tyrosinase were detected.ResultsThe vitiligo gel showed better effects than vitiligo tincture on the formation of AMMC and the activity of acetylcholine esterase and tyrosinase.ConclusionThe vitiligo gel has good effects on experimental vitiligo models over vitiligo tincture.
  • 药物研究
    The Effect of Tetramethylpyrazine on Disposition of Fexfenadine in Isolated Perfusated Rat Liver
    ZHANG Ruhong;ZHANG Linzhi;JIE Jinjie;WANG Fang
    2010, 29(1): 21-24. https://doi.org/10.3870/yydb.2010.01.007
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    ABSTRACTObjectiveTo investigate the effect of tetramethylpyrazine(TMP) on disposition of fexofenadine in isolated perfusate of rat liver. MethodsSD male rats were divided into two groups randomly: treatment group and control group (5 rats respectively). Rats were i.g. 30 mg•kg1•d1 tetramethylpyrazine suspension and the same volume of distilled water for consecutive 14 days. At the 15th day, rat livers were isolated and perfused in a recirculating system, and the both perfusate and bile was collected. The concentrations of fexofenadine in perfusate and bile were determined by RPHPLC. The main pharmacokinetic(PK) parameters were calculated by 3p97 and statistic analysis was conducted by spss 11.5. ResultsThe AUC(060) were 95 016.35±1457.15 and 29 441.44±675.16 (ng•mL1•min1), total clearance were 5.93±0.19 and 19.52±0.51(mL•min1), the total amount excreted into bile Ae(060) were 77 559.93±9 758.37 and 135 145.16±16 211.82 (ng), the biliary clearance CLbwere 0.82±0.24 and 4.59±1.17 （mL•min1 ) for treatment group and control group, respectively. There was a significant difference between them (P＜0.01), but not the volume of distribution V(mL). ConclusionAdministration of tetramethylpyrazine at a high dose for 14 consecutive days can significantly change the PK parameters of Pgp substrate fexofenadine in rat livers, which is likely related to down regulation of Pgp.
  • 药物研究
    The Neuroprotective Effects of Daidzein on Hippocampal Neurons Injury Induced by Glutamate in Vitro on Rats
    QIN Chuanyong
    2010, 29(1): 25-27. https://doi.org/10.3870/yydb.2010.01.008
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    ABSTRACTObjectiveTo investigate the action and mechanism of daidzein on glutamateinduced injury in cultured cerebral hippocampal neuron of rats.MethodsEffects of daidzein on hippocampal neuron injury induced by glumate was determined by observing SOD,MDA and calcium concentration of neuron.ResultsDaidzein prevented the elevation of intracellular calcium and content of MDA, and increased activity of SOD induced by 400 μmol•L1 Glutamate in a concentration dependent manner.ConclusionThe neuroprotective effects of daidzein could be associated with inhibiting intracellular calcium overloading, decreasing MDA content, and increasing activity of SOD.
  • 药物研究
    Study of bioequivalence of Ambroxol Hydrochloride Orally Disintegrating Tablets
    XUE Hongyuan;YANG Hanyu;HE Wentao;WANG Yuqi;JIA Lixia
    2010, 29(1): 27-30. https://doi.org/10.3870/yydb.2010.01.009
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    ABSTRACTObjectiveTo study the bioequivalence and relative bioavailability of ambroxol hydrochloride orally disintegrating tablets. Methods20 healthy male volunteers were taken a single oral administration of 60 mg test and reference tablets, respectively, according to a randomized crossover design.The plasma concentrations of ambroxol were determined by a HPLC/MS/MS method.The pharmacokinetic parameters of the two tablets were calculated.ResultsCmax of a single dose of test and reference tablets were （84.7±29.3） and （81.2±28.2） ng•mL1,tmax were （1.7±0.5） and （1.8±0.4） h, t1/2 were （7.9±0.9） and （8.3±1.0） h, AUC024 h were （638.7±180.8） and （591.4±148.3） ng•h•mL1, respectively.The relative bioavailability of the test tablets was （108.2±16.5） %.ConclusionThe two preparations are bioequivalent.
  • 药物研究
    Effect of Laurocapram on Percutaneous Absorption of Lidocaine in Lidocaine Spray in Vitro
    ZHANG Feng;YANG Mei;MAO Dexiang
    2010, 29(1): 31-33. https://doi.org/10.3870/yydb.2010.01.010
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    ABSTRACTObjectiveTo study the effect of laurocapram in different concentrition on percutaneous absorption of lidocaine in lidocaine spray.MethodsUsing the improved Franze diffusing cells, laurocapram in different concentrition （0,0.5%,1% or 2%） as the penetration enhancer, the accumulative permeation quantity（Q） and permeation rate（P） of lidocaine that penetrated through the isolated mice skin was determined by UV Spectrophotometry in vito.ResultsThe accumulative permeation quantity（Q） of lidocaine is not increased with 0.5% laurocapram, increased 35.82% with 1% laurocapram and increased 58.11% with 2% laurocapram comparing to 0% laurocapram, and the permeation rate（P） reached to 0.20,0.23,0.29,0.34 mg•（cm2）-1•h1 respectively.Conclusion It is indicated that laurocapram has significant effect on percutaneous absorption of lidocaine in lidocaine spray,the 2% laurocapram is the best penetration enhancer for Lidocaine in Lidocaine spray.
    • 药物制剂
  • 药物制剂
    Preparation and Evaluation of Brucea Javanica Oil Liposome
    GANG Honglin;YANG Libin;HU Rong
    2010, 29(1): 75-77. https://doi.org/10.3870/yydb.2010.01.029
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    ObjectiveTo optimize the formulation and preparation of brucea javanica oil liposome. MethodsTo produce brucea javanica oil liposome by thin layer dispersion technique and demonstrate its physicchemical property.The recovery and envelopment were detected by separation method; the shape was observed under electronic microscope; the average diameter and distribution of particles was studied by transmission electron microscope; Zeta potential was tested by microiontophoresis and absorption was detected by spectrophotometer. ResultsThe entrapment efficiency and recovery efficiency were 93.53%and 95.38%, respectively.Most of them were multilamellar vesicles, round and small, the molecular membrane appeared wtih fingerprint spiral structure.The average size was 129.7780 nm and Zeta value was 23.723 9 mv.ConclusionThese results suggested that thin layer dispersion technique is feasible, repeatable, high entrapment efficient and stable.
  • 药物制剂
    The Effects of Preparation Methods on Entrapment Efficiency of Fluorouracil Liposomes by Applying Uniform Design
    YE Peng.;SONG Jinchun;Chen Li
    2010, 29(1): 78-81. https://doi.org/10.3870/yydb.2010.01.030
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    ObjectiveTo study the effects of various preparation methods on the entrapment efficiency of fluorouracil liposomes in order to select the optimum one. MethodsDifferent preparation methods, including film dispersing, reverse phase evaporation, pHgradients and ammonium sulfate gradients were used to prepare the fluorouracil liposomes.Unloaded fluorouracil was separated by SephadexG50 chromatography and detected by HPLC.Uniform design was used to optimize the preparation method and formulation by entrapment efficiency of fluorouracil liposomes.ResultsThe entrapment efficiency of fluorouracil liposomes by active loading method was obviously higher than that by passive loading method.The order of entrapment efficiency was pHgradients method ＞ammonium sulfate gradients＞ reverse phase evaporation ＞ film dispersing method.Using the optimum preparation method and formulation, the average entrapment efficiency could reach at 60.67%.ConclusionPreparation method has the remarkable influence on the entrapment efficiency of fluorouracil liposomes.The higher entrapment efficiency of fluorouracil liposomes can be obtained by pHgradients method.
  • 药物制剂
    Optimization of Extraction Technology of Volatile Oil In Jiawei Xihuang Soft Capsule by Orthogonal Test
    JIN Fen;XIONG Fuliang;SHI Zhaohua;XIONG Dengke;XU Shaoxin
    2010, 29(1): 81-83. https://doi.org/10.3870/yydb.2010.01.031
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    ObjectiveTo study the extraction process of volatile oil in modified xihuang soft capsule. MethodsThe content of octyl acetate was determined by gas chromatography （GC）, which was used to evaluate the extraction rate of volatile oil.The orthogonal design was adopted to optimize the extraction technology of volatile oil.ResultsThe optimum extraction conditions of volatile oil were as follows: adding 7fold water, no soaking, extracting for 7 hours. ConclusionThe technic is suitable for extraction of volatile oil in modified xihuang soft capsule.
    • 药品质量控制
  • 药品质量控制
    Determination of Resveratrol from Jingangteng Soft Capsule by RPHPLC
    HANG Wenting;HUANG Qinwei;DENG Jinming;WU Haiyan;XU Jinjin
    2010, 29(1): 88-89. https://doi.org/10.3870/yydb.2010.01.034
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    ObjectiveTo establish a highperformance liquid chromatographic assay for determining resveratrol in jingangteng soft capsule. MethodsChromatography was performed on an Agilent ExtendC18（4.6 mm×250 mm,5 μm）.The mobile phase was acetonitrile water （22：78）, a flow rate was 1.0 mL•min1 and the detecting wavelength was 306 nm.ResultsThe standard curve was rectilinear in the range of 21.12－316.80 ng （r＝1.000 0） for resveratrol, and the recovery of samples was 101.4%（RSD＝1.9%）.ConclusionThe method is simple, rapid and suitable for the determination of resveratrol in jingangteng soft capsule.
  • 药品质量控制
    Comparison of Osthol Contained in Angelica Pubescens Maxim .f.f and Its Dispensing Granules
    HUANG Liangyong;ZHENG Jiangping;GAN Chunying
    2010, 29(1): 90-91. https://doi.org/10.3870/yydb.2010.01.035
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    ObjectiveTo compare the content of osthol contained in Angelica pubescens Maxim .f.f and its dispensing granules. MethodsHPLC was used to determine the content of osthol in Angelica pubescens Maxim .f.f and its dispensing granules, and a comparison between them was made.ResultsThe ostho in dispensing granules was only half of that in Angelica pubescens Maxim .f.f.ConclusionThe process for producing original formula granules needs to be improved.
  • 药品质量控制
    Study on Quality Standard for Weichangkang Capsules
    ZONG Kai;XIONG Miaomiao;XIE Wei;WANG Qiulan
    2010, 29(1): 92-94. https://doi.org/10.3870/yydb.2010.01.036
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    ObjectiveTo establish the quality standard for weichangkang capsules. MethodsRadix Puerariae in this medicine were identified by TLC. The total contents of magnolol and honokiol were determined by HPLC. ResultsThe qualitative identification with TLC was specific. The methodological study showed a good linear relationship at rang of 0.094 9－1.423 2 μg, 0.040 2～0.602 4 μg. The average recover of magnolol was 101.18% (RSD=1.08%), the average recover of honokiol was 100.47% (RSD=1.89%). ConclusionThe methods are simple rapid accurate and reliable, and can be used for quality control of weichangkang capsules.
  • 药品质量控制
    A Study on the Stability of Banlangen Drop Pills
    MA Yanyan;GUO Meihua;LIU Shiping
    2010, 29(1): 94-96. https://doi.org/10.3870/yydb.2010.01.037
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    ObjectiveTo investigate the stability of banlangen drop pills.MethodsThe active ingredients were determined by HPLC, and the other markers were observed.ResultsBanlangen drop pills were stable after accelerated test and long term test.No significant change in each item was found before and after observation.And it was consistent with regulations of drug quality criteria.ConclusionBanlangen drop pills is stable at room temperature.
    • 用药指南
  • 用药指南
    Prescription Analysis of Metabolic Interactions among Three Proton Pump Inhibitors
    SHEN Bin;ZHANG Jiming;FENG Xiaomin;SHEN Shuijie
    2010, 29(1): 109-111. https://doi.org/10.3870/yydb.2010.01.044
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    ObjectiveTo investigate the combination usage of proton pump inhibitors (PPIs), providing information for proper clinical use of PPIs. MethodsThe retrospective analysis of drug interactions was conducted on a view of drug metabolism. Results2 595 prescriptions were found containing three PPIs, in which the amount of prescriptions coprescribed with CYP 2C19 or CYP3A4 substrates or inducers were 118, 42, and 116 for omeprazole, lansoprazole, and pantoprazole, respectively, accounting for 10.64% of total prescriptions of PPIs. Clarithromycin, nifedipine, domperidone and azithromycin appeared more frequently in this investigation. ConclusionWhen coadministrated with drugs with a narrow therapeutic window, such as phenytoin or warfarin, the dose of omeprazole should be adjusted. A sulfotransferase was involved in metabolism of pantoprazole and the affinity of pantoprazole to CYP P450 was low. Therefore, pantoprazole has lower drug interaction potential with substrates or inducers of CYP 2C19 or CYP 3A4. Clinical pharmacists should devote to prescription checking and pharmaceutical service for patient on proper use of drugs. Monitor blood concentrations for suspected drug interactions, if necessary.
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