中国科技论文统计源期刊 中文核心期刊
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
Objective To evaluate the therapeutic efficacy of shenqifuzheng injection combined with 3dimenation conformal radiotherapy(3D-CRT) for patients with advanced nonsmall cell lung cancer. Methods 97 eligible patients without operation were randomized into two groups, 46 in the treatment group and 51 in the control group. All patients received 3D-CRT for 60－70 Gy/ 6 to 7 weeks. During radiation, patients in thetreatment group were intravenously dripped with 250 mL,qd shenqifuzheng injection additionally. The shorttime curative effect and the acute radiation pneumonitis, esophagitis and myelosuppression in both groups were compared. Results The complete recovery (CR) and partly recovery (PR) rates were 11.3%(11/97) and 46.4%(45/97) in all patients. The overall response rate (CR+PR ) was 57.7%, and no differences were found between two groups(P＞0.05). The incidences of 2 and 3 grade’s acute radiation pneumonitis, esophgitis and hemotologic toxicity occurred in the treatment group and the control group were 6.5%,21.7%,13.0% and 21.6%,25.5%,31.4%,respectively. The incidence of acute radiation pneumonitis and hemotologic toxicity in control group was significantly high than those in treatmentgroup (P＜0.05). Conclusion Shenqifuzheng injection combined with 3DCRT decreases the acute radiationinduced injury without changing the shorttime curative effect in treating advanced nonsmall cell lung cancer.
Objective To establish a method for determination of the hydrophilic of danshensu, protocatechuic aldehyde, salvianolic acid B and lipophilic compounds of dihydrotanshinone I, cryptotanshinone, tanshinone I and tanshinone IIA in Radix Salviae Miltiorrhizae. Methods Chromatography was performed on a LichrospherC18 column (250 mm ×4.6 mm i. d.; 5 μm particle size). The separation was achieved by a linear gradient elution. Mobile phase was the mixture of solvent A (1% aqueous formic acid) and solvent B (acetonitrile). The gradient elution was conducted as follows: 10%－20% B in 0－10 min, 20%－33% B in 10－27 min, 33%－70% B in 27－30 min, and 70%－85% B in 30－50 min. The injection volume of 10 μL and the UV wavelength of 280 nm were used in the analysis. The flow rate was 1.0 mL•min-1 and the column operated at 20 ℃. Results A good linearity was obtained with the correlation coefficients of tanshinol, protocatechualdehyde, salvianolic acid B, dihydrotanshinone I, cryptotanshinone, tanshinone I and tanshinone IIA ranged from 0.037 2－118.000 0 mg•L-1, 0.017 4－8.900 0 mg•L-1, 0.141－450.000 mg•L-1, 0.018 8－56.800 0 mg•L-1, 0.049 7－158.000 0 mg•L-1, 0.021 5－78.500 0 mg•L-1, 0.096 2308.000 0 mg•L-1(R2≥0.999 2), respectively. The average recovery rates of the four investigated compounds were in the range of 98.5%－101.5% for all with RSD below 1.98% (n=6). The intraday and interday precision of the assay were no more than 2.16% (n=6). Conclusion The method is accurate and reliable with good reproducibility, and can be used as a determination standard for Radix Salviae Miltiorrhizae.
