药物研究
YU Daojun;DONG Xiaoqin;JIN Keqin;ZHOU Tianmei;CHEN Yueming;WU Shenghai
2008, 27(3): 280-284.
(1. ABSTRACTObjectiveTo analyze the antibiosis effect of antibiotics combination on multidrug resistant Acinetobacter Baumarnii in vivo and in vitro. MethodsDrug resistant genetypes of 36 strains multidrug resistant acinetobacter Baumarnii were identified and the minimum bactericidal concentration (MBC) of 8 antibiotics to multidrug resistant acinetobacter Baumarnii were determined. The mice infected by multidrug resistant acinetobacter Baumarnii were treated by 8 antibiotics combination under the minimum inhibition concentration. ResultsDrug resistant genetypes of 36 strains multidrug resistant acinetobacter Baumarnii were OXA23.The MBC(μg•mL1) of tienem,tazocillin,suloerazon,rifampicin,ceftazidime,amikacin,ciprofloxacin , polymyxin E was 64,512,64,250,2 048,2 048,150,2,respectively. The antibiotics combination of tienem and amikacin ,tazocillin and rifampicin ,tienem and Rifampicin, could not inhabit multidrug resistant acinetobacter Baumarnii, but suloerazon combined with amikacin showed a sterilization . The protection rate of antibiotics combination of polymyxin E plus tazocillin,tazocillin plus amikacin and suloerazon plus amikacin was 100.0%,30.0%,90.0% and 90.0%,respectively. Mortality of the infectious mice treated with tienem and suloerazon was 100%. ConclusionsThere was obviously increased in MBC of common antibiotics for multidrug resistant acinetobacter Baumarnii. Reasonable combination antibiotics was available to therapy multidrug resistant acinetobacter Baumarnii, and was also able to reduce the dosage of agents.