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    药物研究
  • 药物研究
    An Experimental Study of the in vitro Anticytomegalovirus Effect of the Traditional Chinese Medicine Houttuynia
    WANG Xinrong;CHEN Suhua;LIU Haizhi;ZHANG Xinhong;DENG Qunrong;CHEN Li;DENG Dongrui
    2007, 26(6): 579-581.
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    An Experimental Study of the in vitro Anticytomegalovirus Effect of the Traditional Chinese Medicine Houttuynia
    WANG Xinrong, CHEN Suhua, LIU Haizhi,ZHANG Xinhong, DENG Qunrong ,CHEN Li, DENG Dongrui (Department of Gynecology and Obstetrics, Tongji Hospital Affiliated with the Tongji Medical College , Huazhong University Science and Technology, Wuhan 430030,China)ABSTRACTObjective To study the in vitro anticytomegalovirus effect of the traditional Chinese medicine houttuynia.MethodsThe maximum innocuity concentration(TD0), minimum effective concentration（MEC） and therapeutic index(TI) of houttuynia in its anticytomegalovirus activity were detected with the cytopathic assay and MTT method. Jinyebaidu(JYBD) and ganciclovir were used as the control drugs. ResultsThe TD0 of houttuynia , JYBD and ganciclovir were 30, 3 mg·mL-1 and 100 μg·mL-1, respectively,the MEC of the 3 drugs were 300,30 and 10 μg·mL-1 ,respectively, and their therapeutic indices (TI) were 100,100 and 10, respectively . ConclusionThe traditional Chinese medicine houttuynia was shown to be provided with an in vitro anticytomegalovirus effect with relatively low drug toxicity. KEY WORDSHouttuynia ; Cytomegalovirus; Guinea pig
  • 药物研究
    Antiapoptotic and Neuroprotective Effects of the Antioxidant Edaravone in Rats Subjected to Cerebral IschemiaReperfusion Injury
    SONG Guijun;TANG Jianwu;YIN Lin;WANG Naichang;BAO Liping
    2007, 26(6): 582-585.
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    Antiapoptotic and Neuroprotective Effects of the Antioxidant Edaravone in Rats Subjected to Cerebral IschemiaReperfusion Injury
    SONG Guijun1, TANG Jianwu2, YIN Lin1, WANG Naichang1 , BAO Liping1 （1.Department of Neurology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China; 2. Department of Pathophysiology , Dalian Medical University, Dalian 116027, China）ABSTRACTObjectiveTo study the antiapoptotic and neuroprotective effects of the antioxidant edaravone in rats with a model of ischemiareperfusion injury. Methods84 SD rats were randomly divided into 3 groups:①the sham operation group(n=4),② ischemiareperfusion(IR) group(n=40),and③edaravone treatment group(n=40).A model of cerebral ischemiareperfusion injury was set up in each of the rats of groups② and group③ by suturetying and untying the middle cerebral artery. Rats of group② and group③ were further divided into 2, 6, 12, 24 and 48 hour subgroups according to the time of reperfusion. Rats of group③ were given each an IV injection of 3 mg·kg1 of edaravone following the 2 hour ischemia. 24 h later a second injection of the same dose of edaravone was given to each of the rats of group③ by the same route. Rats of group③ were given each injections of equivalent amounts of physiologic saline solution at the same times and in the same manner as described above. The serum concentration of malonyldialdehydc(MDA) was determined with the colorimetric method. Bcl2 immunohistochemical method and TUNEL staining were used to determine the expression of the bcl2 protein and number of TUNELpositive apoptotic cells in the brain tissue.The sizes of the brain infarction were assessed as well. ResultsAfter 6,12,24 and 48 hours of reperfusion, the sizes of brain infarction in rats of group③ treated with edaravone were obviously smaller than those in rats of group②(P＜0.05),and the serum MDA concentrations in rats of group③ were significantly lower than those in rats of group②(P＜0.05). In addition, there was an evident increase in the expression of bcl2 protein (P＜0.01) and a striking decrease in the number of TUNEL positive apoptotic cells in the brain tissue of the rats in group③ treated with edaravone as compared with those in rats of group② at the same time points (P＜0.01). ConclusionEdaravone was shown to have an excellent neuroprotective effect in rats subjected to an ischemiareperfusion brain injury possibly by scavenging free radicals and a bcl2 dependent antiapoptotic mechanism.KEY WORDSEdaravone ；Reperfusion injury ； Apoptosis ； Neuroprotective agents
  • 药物研究
    Effect of Meibao Oral Liquid on the Immune Function of Mice
    CAI Huafang
    2007, 26(6): 585-587.
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    Effect of Meibao Oral Liquid on the Immune Function of Mice
    CAI Huafang（Institute of Materia Medica, Zhejiang Provincial Academy of Medical Sciences, Hangzhou 310013, China）ABSTRACTObjective To survey the effects of Meibao oral liquid on the immune function of mice. MethodsFifty ICR mice were randomly divided into 5 equal groups. Mice of the blank control group were given each 25 mL·kg1 of pure water administered by gastrogavage q.d. .Mice of the positive control group were given each 5.0 g·kg 1 of the aqueous extract of ginseng administered by gastrogavage q.d.. Mice of the three trial groups were given each 10.0 , 5.0 , 2.5 g·kg1 of Meibao oral liquid ,respectively, administered by gastrogavage q.d. as well.The course of treatment in all 5 groups lasted 10 consecutive days. The function of the peritoneal macrophage to phagocytiye chicken red blood cells, serum haemolysin concentration (HC), hemolytic capability of antibody forming cells (quantitative hemolysis of SRBC, QHS ) , number of splenic plaqueforming cells (PFC)and proliferation of the splenic lymphocyles of the animals were assayed. ResultsMeibao oral liquid in does of 10.0 and 5.0 g·kg1 was shown to promote the phagocytic function of the macrophage (P＜0.01), increase HC , QHS and PFC and enhance spleniclymphocyte proliferation in mice. Conclusion Meibao oral solution was shown to be provided with striking immunoenhancing effects.KEY WORDSMeibao oral liquid；Immuno function［Note:Meibao oral liquid was composed of Pteria margaritifera (L.) powder ,Panax ginseng ,Lycium Chinese Mill ,etc..］
  • 药物研究
    Pharmacokinetic Characteristics and Bioequivalence of Paroxetine Tablets in Healthy Chinese Volunteers
    LIU Weizhong;HUANG Weiqiao;WANG Guangfa;WANG Huacheng;LIN Yuhua
    2007, 26(6): 588-591.
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    Pharmacokinetic Characteristics and Bioequivalence of Paroxetine Tablets in Healthy Chinese Volunteers
    LIU Weizhong1,HUANG Weiqiao2 ,WANG Guangfa1,WANG Huacheng1,LIN Yuhua1(1. Clinical Research Base for State Remedies, Guangzhou Municipal Hospital of Brain Dieases , Guangzhou 510370,China；2.Department of Pharmacy ,the First Affiliated Hospital, Sun Yatsen University, Guangzhou 510080,China)ABSTRACTObjectiveTo study the pharmacokinetic characteristics of paroxetine tablets in healthy Chinese volunteers and to compare the bioequivalence between two preparations of paroxetine tablets. Methods20 healthy volunteers in a randomized crossover study were given each a single oral dose of 40 mg of test or reference paroxetine tablets . The plasma concentration of paroxetine was determined with HPLC. The pharmacokinetic parameters were calculated while the bioavailability and bioequivalence of the two preparations were evaluated with the 3P97 pharmacokinetic software. ResultsThe main pharmacokinetic parameters for test and reference preparations were Cmax: (62.78±17.34) and （64.74±18.43） ng·mL-1；tmax: (5.13±1.37） and （5.64±1.84） h；t1/2: (19.85±5.72） and （20.03±5.33） h；AUC0-120: (1 043.21±297.33） and（1 076.47±309.49） ng·h-1·mL-1； AUC 0－inf: (1 358.35±443.73） and （1 386.75±476.54） ng·h-1·mL-1, respectively. The relative bioavailability of the test and reference preparations F0-120: (98.9±16.3）% and F0-inf: (96.3±18.2）%, respectively. ConclusionThe two preparations of paroxetine tablets were shown to be bioequivalent.KEY WORDSParoxetine; Pharmacokinetics; Bioequivalence; Chromatography,high pressure liquid

  • 药物研究
    Determination of Zolmitriptan in Human Plasma with HPLC
    YE Jinwei
    2007, 26(6): 591-593.
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    Determination of Zolmitriptan in Human Plasma with HPLC
    YE Jinwei(Department of Pharmacy,the Central Hospital of Lishui City,Lishui 323000,China )ABSTRACTObjectiveTo develop an HPLCfluorescence detection method for the determination of zolmitriptan in human plasma.MethodsSeparation was achieved on a Zorbax SBC18(4.6 mm×150 mm, 5 μm) column at 30 ℃. The mobile phase consisted of a mixture of acetonitrile and water(containing 0.04% triethylamine,pH adjusted to 2.5 with phosphoric acid)(11：89) pumped at a flow rate of 1.0 mL·min1. A fluorescence detector was set at λex 235 nm，λem 360 nm. With the use of rizatriptan as the internal standard, zolmitriptan in plasma samples was determined with HPLC by liquidliquid extraction of the compound from alkalinized plasma into an organic solvent. ResultsThe drugfree plasma did not interfere with the determination of drugs and internal standard. There were good linear relationships between peak area ratio of zolmitriptan to internal standard and C（r＝0.999 7）within the range of 0.2～40.0 μg·L1.The lower limit of quantification was 0.2 μg·L1.Intra and interassay coefficients did not exceed 10%.The analytes reconstituted in the mobile phase were also stable at ambient conditions for at least 12 h. Furthermore, zolmitriptan was stable for at least three freezethaw cycles. ConclusionThe method was shown to be sensitive, convenient and accurate and is suitable for the determination of zolmitriptan concentrations in human plasma and pharmacokinetic studies.KEY WORDSZolmitriptan; Chromatography,high pressure liquid;Spectrometry,fluorescence; Human plasma concentration; Rizatriptan

    • 妇产科用药专栏
  • 妇产科用药专栏
    A Study of the Effectiveness and Safeness of the Antifertility Action of Triptolide in Rats
    XU Yuanping;ZHANG Hanwang;XIAO Fenghua;WANG Chen;ZHAO Ling
    2007, 26(6): 594-596.
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    A Study of the Effectiveness and Safeness of the Antifertility Action of Triptolide in Rats
    XU Yuanping1，ZHANG Hanwang1，XIAO Fenghua2 ， WANG Chen1，ZHAO Ling 3
    （1. Center of Genesiology Tongji Hospital Affiliated with the Tongji Medical College,Huazhong University of Science and Technology，Wuhan 430030 ；2. Department of Gynaecology and Obstetrics , Medical School of Jinggang Mountain College， Jiangxi 343000； 3. Department of Pharmacy , the 12th Hospital of Wuhan City，Wuhan 430074,China）ABSTRACTObjectiveTo probe into the site of the antifertility action of triptolide as well as the safeness of its administration in rats . MethodsThirty healthy male Wistar rats were used to study the impact of triptolide on spermatogenesis and histology of the testicle, epididymis and visceral organs, including the heart, liver ,kidney etc.. The course of the experiment was divided into two stages. 6 animals used in the first stage were randomly divided into 2 equal groups .Rats of the trial group 1(n=3) were given each 0.05 mg·kg-1 of triptolide［dissolved in 1% dimetlyl sulfoxide (DMSO)］ administered by gastrogavage q.d. in 6 days of a week for 8 consecutive weeks. Rats of the control group 1(n=3) were given each 2 mL·kg-1 of 1% DMSO in the same manner and duration as described above. 24 rats used in the second stage of the experiment were randomly divided into 4 equal groups with 6 animals in each group. Rats of the trial groups 2, 3 and 4 were given each 0.10，0.05 and 0.03 mg·kg-1 of triptolide administered by gastrogavage q.d. , respectively ,in 6 days of a week for 4 consecutive weeks . Rats of the control group 2 were given 1%DMSO 2 mL·kg-1·d-1 in the same manner and duration. The animals were weighed every week, and tissues were taken for studying the state of apoptosis of the testicular spermatogenic cells, vitality of epididymal spermatozoa and histology of the heart, liver, kidney and testicle. ResultsVitality of the spermatozoa in rats of the trial groups was significantly decreased. No vitality (zero vitality) of the spermatozoa was demonstrated when the dosage of triptolide was≥0.05 mg·kg-1·d-1. Seminiferous epithelium of the convoluted seminiferous tubules was injured, with exfoliation of the luminal epithelium. No remarkable morphological anomaly was found in the relevant organs in rats of the control groups. The difference between rats of the trial groups and control groups with respect to the state of apoptosis of testicular spermatogenic cells was insignificant ,as demonstrated by flow cytometry. The difference between body weights in rats of the controls groups and those of the trial groups treated with different doses of triptolide was insignificant as well.ConclusionTriptolide was shown to be an effective antifertility drug with trivial tissue toxicity ,and its contraceptive effect is reversible.KEY WORDSTriptolide ;Fertility ;Contraception; Rats

  • 妇产科用药专栏
    Effect of Mifepristone Integrated with Misoprostol on the Transcription Levels of PRmRNA,ERmRNA and the Expression Levels of PR,ER in the Villus and Decidua from Women in Early Pregnancy
    PENG MIN;HE Fuxian
    2007, 26(6): 597-599.
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    Effect of Mifepristone Integrated with Misoprostol on the Transcription Levels of PRmRNA,ERmRNA and the Expression Levels of PR,ER in the Villus and Decidua from Women in Early Pregnancy
    PENG MIN1，HE Fuxian2（1. Department of Gynecology and Obstetrics, Hubei Provincial Maternity and Child Care Hospital, Wuhan 430070, China；2. Department of Gynaecology , Tongji Hospital Affiliated with the Tongji Medical College,Huazhong University of Science and Technology，Wuhan 430030,China ）ABSTRACTObjectiveTo survey the effect of mifepristone integrated with misoprostol on the transcription levels of PRmRNA,ERmRNA and the expression levels of PR,ER in the villus and decidua from women in early pregnancy. MethodsThe trial group of the present study was composed of 32 women in early pregnancy who were subjected to the drugindueed abortion, the drug being mifepristone integrated with misoprostol. 31 women subjected to artificial abortion served as controls FQ(fluorescent quantitative)PCR was adopted to detect the transcription levels of PRmRNA and ERmRNA in the villus and decidua from the women of both groups while the levels of expression of PR and ER in the villus and decidua from these women were assayed with immunochemical methods. ResultsThe transcription levels of ERmRNA and PRmRNA as well as the expression levels of ER and PR were significantly lower in the villi and deciduas from women subjected to the druginduced abortion as compared with those from women of the control group(P＜0.01,P＜0.01) .ConclusionThe effect of mifepristone integrated with misoprostol to terminate early pregnancy may be related to its influence on the transcription levels of ERmRNA and PRmRNA as well as expression levels of ER and PR in the villus and decidua.KEY WORDSMifepristone ; Misoprostol ; Receptors ,estrogen ;Progestins
  • 妇产科用药专栏
    Expression of the FHIT Gene in Human Cervical Carcinoma Cell Lines and Its Regulation by Methylation
    WU Ying;WANG Shixuan;MA Ding
    2007, 26(6): 600-603.
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    Expression of the FHIT Gene in Human Cervical Carcinoma Cell Lines and Its Regulation by Methylation
    WU Ying1, WANG Shixuan2, MA Ding2 (1.Department of Gynecology , Hubei Provincial Maternity Child Care Hospital, Wuhan 430070, China； 2.Department of Gynecology and Obstetrics,Tongji Hospital Affiliated with the Tongji Medical College,Huazhong University of Science and Technology，Wuhan 430030 , China)ABSTRACTObjectiveTo probe into the effect of DNA methylation on the expression of fragile histidine triad (FHIT) gene in human cervical carcinoma cells. MethodsFour human cervical carcinoma cell lines(C-33A, HeLa, CasKi, SiHa) and one normal human umbilical vein endothelial cell line (ECV304) were incubated and treated with the DNA methyltransferase inhibitor 5aza2’deoxycytidine( 5azadC) in different concentrations . The expression of FHIT in the cells before and after the 5azadC treatment was assayed with RTPCR. The growth curve and proliferation of the cells were detected with the MTT test and direct counting method simultaneously and flow cytometry was used to assay the changes in the cell cycles and the rates of apoptotic cells before and after the 5azadC treatment. ResultsThe expression of FHIT that could hardly be detected in all four cervical carcinoma cell lines before the 5azedC treatment was enhanced in varying degrees after the treatment. In contrast, the normal control ECV304 cell line manifested fairly strong expression of FHIT mRNA before and after 5azadC treatment. The difference between the cancer cells and normal cells with respect to this parameter was significant (P＜0.05). There was a marked drop of the growth curves in the four cervical carcinoma cell lines after the 5azadC treatment while no obvious changes in the growth curve were shown in the ECV304 cell line after the treatment (P＜0.05). The results of MTT test showed that the proliferation rate and survival rate of the cervical carcinoma cells were strikingly decreased after exposure to 5azadC in different concentrations while those of the normal control cells were not apparently affected (P＜0.05) . The results of flow cytometry revealed that the cells of the four cervical carcinomas exposed to 5azedC were blocked in the G1 phase and had an increased rate of apoptosis. These changes were most pronounced after CasKi and C33A cell had been treated with 5azedC at concentrations of 2×106 and 106 mmol·L1. In contrast, the ECV304 cells showed little changes in cell cycle and apopotasis rate under the same conditions (P＜0.05). ConclusionAberrant methylation of the FHIT gene seems to be an important mechanism underlying its downregulation of expression .As a tumor suppressor gene , the FHIT gene may play an important role in the occurrence and development of cervical carcinoma. It may be possible to block the advancement of cancer by artificial inhibition of the methylation of FHIT. KEY WORDSUterine cervical carcinoma; DNA methylation; Gene， fragile histidine triad (FHIT)
  • 妇产科用药专栏
    A Clinical Observation on the Effect of Intravaginal Administration of Misoprostol during Late Pregancy A Clinical Observation on the Effect of Intravaginal Administration of Misoprostol during Late Pregancy
    XIAO Jianhua;ZHANG Fen;REN Hong;KE Yulan
    2007, 26(6): 605-606.
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    A Clinical Observation on the Effect of Intravaginal Administration of Misoprostol during Late Pregancy
    XIAO Jianhua ，ZHANG Fen ,REN Hong ,KE Yulan ( Department of Obstetrics and Gynecology, Red Cross Hospital, Shiyan 442053,China) ABSTRACTObjectiveTo probe into the way of administration and effect of misoprostol in the induction of labor during late pregancy. Methods162 women in late pregnancy who had indication to induced labor but no contraindication to the use of misoprostol were randomly divided into 2 groups: group A(n=82) and group B(n=80). Women of group A were given each a single dose of 100 μg misoprostol administered intravaginally deep into the posterior fornix. Gravidas of group B were given each 50 μg of misoprostol administered in the same manner as described above. The same medication, however, was repeated every 4－6 h until parturiency was reached. The maximum dose of the drug in 24 h was 200 μg. The effect on labor induction, adverse reactions, progress of labor and the influence on the mother and child were kept under observation. ResultsThe rate of success in labor induction in gravidas of group A was 84.1%. The time of the birth process averaged (569.5±132.2) min. 3 subjects of this group experienced mild nausea. The rate of success in labor induction in women of group B was 80.0%. The birth process lasted (674.8±382.5) min on average. 2 gravidas of this group complained of mild nausea. Differences between the 2 groups were insignificant (P＞0.05).No precipitate labor nor neonatal asphyxia was encountered. Conclusion Intraviginal administration of misoprostol was shown to have excellent and safe effects in the induction of labor during late pregnancy. Adverse reactions were mild and rare. Intravaginal administration of one single dose of the drug was shown to be a more handy way to obtain comparable results. KEY WORDSMisoprostol ; Pregancy ,late ; Labor, induced

  • 妇产科用药专栏
    Nanosilver Combined with Microwave Radiation in the Treatment of Patients with Cervical Erosion
    LIU Xianhua;DENG Xiaoyan
    2007, 26(6): 607-609.
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    Nanosilver Combined with Microwave Radiation in the Treatment of Patients with Cervical Erosion
    LIU Xianhua1, DENG Xiaoyan2(1. Caidian District Counselling Station for Family Planning, Wuhan 430100, China; 2. Department of Obstetrics and Gynecology,the First Hospital of Wuhan City, Wuhan 430022, China)ABSTRACTObjectiveTo study the therapeutic effectiveness of nanosilver combined with microwave radiation in the treatment of patients with cervical erosion. Methods416 patients with cervical erosion were randomly divided into two groups. 201 patients of the control group were treated only with microwave radiation for 30－120 s q.d. for three days. 215 patients of the trial group were given each 0.2 g of nanosilver tablets administered intravaginally before and after the microwave radiation for 3 consecutive days. Vaginal discharge and bleeding as well as the state of healing of the wound surface in patients of both groups were kept under observation after the treatment. ResultsThe time of vaginal discharge was strikingly shorter and the amount of vaginal bleeding much smaller in patients of the trial group than those in patients of the control group. Besides, healing of the cervical wound surface was also significantly faster in patients of the trial group than that in patients of the control group. The differences were all significant (P＜0.01). Conclusion Treatment of cervical erosion with nanosilver combined with microwave radiation was shown to dramatically shorten the time of vaginal discharge, decrease the vaginal bleeding and speed up the healing of the cervical wound surface after the microwave radiation. KEY WORDSNanosilver ； Microwave ；Uterine cervical erosion
    • 药物与临床
  • 药物与临床
    Effect of Fluoxetine to Improve the Symptoms of Retardation and Vigor Deficiency in the Treatment of Depression
    LU Qiang;XU Songquan;YING Yifei;HE Faxiang;ZHU Guidong
    2007, 26(6): 615-618.
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    Effect of Fluoxetine to Improve the Symptoms of Retardation and Vigor Deficiency in the Treatment of Depression
    LU Qiang1, XU Songquan2, YING Yifei2 , HE Faxiang2, ZHU Guidong2（1. Department of Psychiatry, the Second People’s Hospital of Taizhou City, Taizhou 318000 ,China；2. Department of Psychiatry, the Second People’s Hospital of Lishui City, Lishui 323000,China）ABSTRACTObjectiveTo compare the therapeutic effects of fluoxetine and amitriptyline in the treatment of the symptoms of retardation and vigar deficiency in patients with depressin. Methods55 patients with depression were randomly divided into two groups: group A (n=29) and group B (n=26). Patients of group A were given each 20 mg of fluoxetine PO, q.d., while patients of group B were given each 150 mg of amitriptyline, PO, b.i.d. . The course of treatment in the two groups lasted 6 weeks. According to the the HAMD (Hamilton Depression Scale) retardation factor scoring, these patients were categorized into 2 subgroups: the low retardation subgroup (HAMD score ＜8) and high retardation subgroup (HAMD score ≥8), with reference to the baseline scoring level. The charges in vigor were measured with the HAMD retardation factor scoring and items in the SCL58(Sympton Check List) that were relevant to vigor. ResultsThe HAMD total score , retardation factor score and the scores of the vigorrelated items in the SCL58 in patients of both groups were significantly decreased after the 6 week treatment. The decrease in these sores was still more pronounced in patients treated with fluoxetine as compared with that in patients treated with amitriptyline. Moreover, the differences between these scores after even 1 and 2 weeks of treatment and those before the treatment in patients of both groups were significant (P＜0.05 or P＜0.01). The difference between the therapeutic effects of fluoxetine in the treatment of patients suffering from high retardation and low retardation was insignificant (P＞0.05) . The therapeutic effect of amitriptyline in the treatment of patients with high retardation was inferior to that in patients with low retardation (P＜0.05). The therapeutic effect of fluoxetine in the treatment of patients in the high retardation subgroup was still better than that of amitriptyline (P＜0.05). ConclusionEarly application of fluoxetine was shown to significantly improve the depressionrelated disturbances in vigor. The drug exerted still more striking sedative effects in patients with high HAMD retardation factor scores .KEY WORDSFluoxetine; Amitriptyline; Depression

  • 药物与临床
    A Comparison between the Therapeutic Effectiveness and Safeness of Aripiprazole and Chlorpromazine in the Treatment of Firstepisode Schizophrenia
    XIA Shiyan;WU Chao;YU Hong
    2007, 26(6): 619-620.
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    A Comparison between the Therapeutic Effectiveness and Safeness of Aripiprazole and Chlorpromazine in the Treatment of Firstepisode Schizophrenia
    XIA Shiyan ， WU Chao， YU Hong（Mental Health Centre of Zhejiang Provincial Xiaoshan Hospital,Hangzhou 311200,China）ABSTRACTObjectiveTo compare the therapeutic effectiveness and safeness of aripiprazole and chlorpromazine in the treatment of firstepisode schizophrenia.Methods60 patients with firstepisode schizophrenia were randomly divided into two equal groups: group A( treated with aripiprazole) and group B( treated with chlorpromazine). Patients of group A and group B were given each (15.0±3.6) mg of aripiprazole (on average) and (325±84) mg of chlorpromazine (on average) PO per day, respectively, for 6 consecutive weeks. Therapeutic effectiveness and adverse reactions in patients of both groups were assessed with the positive and negative syndrome scale （PANSS）and treatment emergent side effect scale (TESS), respectively. ResultsA significantly greater decrease in the scores of negative symptoms as shown by the PANSS was demonstrated in patients treated with aripiprazole as compared with that in patients treated with chlorproimazine at the termination of the 6 week treatment.The differences between the 2 groups with respect to symptoms, general psychopathological symptoms and the decrease in the total sores of the PANSS were insignificant (P＞0.05).Adverse reactions in patients treated with aripiprazole were less commonly encountered than those in patients treated with chlorpromazine . ConclusionThe therapeutic effectiveness of aripiprazole in the treatment of firstepisode schizophrenia was shown to be superior to that of chlorpromazine,and the adverse reactions of the former drug were less common.
  • 药物与临床
    Citalopram in the Treatment of 31 Cases of Depressive Mood Disorder with Headache as the Chief Complaint
    LIU Guangjian;WANG Hua;WANG Yunfu;HE Guohou;LUO Guojun;HUANG Chaofen
    2007, 26(6): 621-624.
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    Citalopram in the Treatment of 31 Cases of Depressive Mood Disorder with Headache as the Chief Complaint
    LIU Guangjian, WANG Hua, WANG Yunfu , HE Guohou, LUO Guojun, HUANG Chaofen(Department of Medical Neurology, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan 442000, China)ABSTRACTObjectiveTo compare the therapeutic effectiveness and safeness of citalopram and amitriptyline in the treatment of depressive mood disorder with headache as the chief complaint. Methods91 cases of depressive mood disorder with headache as the chief complaint meeting the criteria of selection were randomly divided into 3 groups: the trial group (n=31), control groups 1(n=30) and 2(n=30).Patients of the trial group, control group 1 and control group 2 were given each 20 mg·d-1 of citalopram, 100－150 mg·d-1 of amitriptyline and epuivalent amount of analgesics PO, respectively, for 6 consecutive weeks. The clinical manifestations in patients of the 3 groups were assessed with the Hamilton Depression Scale(HAMD Scale) before the treatment as well as 1,2,4 and 6 weeks after the beginning of the treatment. Adverse reactions of the drugs were evaluated at the corresponding time points after the beginning of the treatment. ResultsThe rates of clinical improvement in patients of the trial group and control group 1 after the 6 week treatment were 87.1% and 86.7%, respectively. The majority of patients in these 2 groups experienced remission of headache, improvement in sleeping and restoration of living and working capabilities. The rate of clinical improvement in patients of the control group 2 was as low as 26.7%. The HAMD scoring in patients of the trial group was strikingly decreased after 1 to 2 weeks of treatment as compared with that before the treatment(P＜0.05). The decrease in the HAMD scoring in patients of the control group 1, however, was not significant after the 1－2 week treatment (P＞0.05). The HAMD scorings in patients of the trial group and control group 1 were both significantly decreased after 4 to 6 weeks of treatment (P＜0.01), the difference between these 2 groups ,however,being insignificant(P＞0.05). Adverse reactions in patients of the trial group were relatively mild and rare as compared with those in patients of the control group 1 but were comparable with those in patients of the control group 2. ConclusionThe effect of citalopram in the treatment of depressive mood disorder with headache as the chief complaint was shown to be comparable with that of amitriptyline. However, citalopram started to act earlier, had greater safeness and fewer adverse reactions.KEY WORDSCitalopram; Amitriptyline; Headache; Mood disorder, depressive
    • 药物制剂
  • 药物制剂
    A Study of the Technology for the Separation and Purification of Total Saponin from the "WuHe" Dipsacus Root with Macroporous Adsorption Resin
    ZHAO Li;ZHANG Changgong;ZHONG Qiaoni;LEI Yuxia;CHENG Ming;WANG Zhong
    2007, 26(6): 649-651.
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    ABSTRACTObjectiveTo study the technology for the separation and purification of total saponin from the "WuHe" dipsacus root with macroporous adsorption resin as well as to define the optimum technological conditions and parameters. MethodsAfter the "WuHe" dipsacus root had been extracted with 95% ethanol, the extract was concentrated until no alcoholic smell was left. The extract was then dissolved in water and added onto a macroporous absorption resin column. The content of the total saponin was determined with vanilinsulfuric acid colorimetry at a detection wavelength of 532 nm. With the use of the concentration of the total saponin as an observation index, the technological parameters that interfered with the separation and purification of the total saponin were investigated. ResultsThe D101 macroporous resin was shown to be the best resin for the separation and purification of the total saponin from the "WuHe" dipsacus root. The technological conditions were as follows: the concentration of samples added onto the column was 0.75 mg·mL1, the maximum absorption amount of 1 g of resin was 0.85 g of the crude drug of "WuHe" dipsacus root,the eluent was 50% ethanol , the optimum flow rate was 1 mL·min1, 5 volumes of the eluent were used for 1 volume of the resin. Conclusion The total saponin in the "WuHe" dipsacus root was well separated and purified with the D101 macroporous resin under the defined technological conditions. The content of the total saponin was greater than 50% of the solid mateial, and the rate of recovery of the total saponin was higher than 91%.The method is suitable for largescale industrial preparation of total saponin from "WuHe" dipsacus root.
  • 药物制剂
    An Orthogonal Experiment Designed to Optimize the Technology for the Extraction of the Percolate of the Potentila Freyniana Borum
    LIU Xinguo; WEI Yuanfeng;HAN Jianwei;HE Wei
    2007, 26(6): 652-654.
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    ABSTRACTObjectiveTo optimize the technology for the extraction of the percolate of the potentila freyniana borum. MethodsThe content of the total tannin and catechin in the samples were determined with UV spectrophotometry and HPLC, respectively.An orthogonal experimental design was adopted to optimize the technology for the extraction of the percolate. Results The optimum conditions for the extraction technology were found to be: the concentration of ethanol was 60%, the time for immersion of the drug was 24 hours，10 volumes of ethanol were used for the extraction of 1 volume of the drug and the flow rate was 0.3 mL·min-1．ConclusionThe method for the content determination was shown to be accurate in the quantitation of total tannins and catechin　in the potentila freyniana borum , and the optimiazed technology was stable and feasible .
    • 药品质量控制
  • 药品质量控制
    Quality Control of Yiwei Kangbao Capsules
    GUO Meihua;XU Chunyan;HU Baorong
    2007, 26(6): 660-662.
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    (1. ABSTRACT ObjectiveTo set up the quality standards of yiwei kangbao capsules . MethodsThin layer chromatography (TLC) was used to identify ferulic acid and tetrahydropalmatine . Content uniformity and time limit of disintegration were examined with weighing and inspection,respectively. HPLC was used to determine the content of tetrahydropalmatine. The chromatographic conditions were : a SinoChrom ODSBP (4.6 mm×250 mm,5 μm) column served as the solid phase ,the mobile phase was methanol0.1% phosphoric acid solution (pH adjusted to 6.0 with triethylamine)(60：40). the detection wavelength , 282 nm.ResultsThe TLC method was shown to be specific. The content difference was in the range of ±10%.The samples used in the examination were totally disintegrated within 7.9－10.7 min.The HPLC method was accurate and reliable, the linear relationships were excellent.The average rate of recovery was 97.20%，with an RSD of 1.26%.ConclusionThe quality standards were precise ,comprehensive,reliable and suitable for the quality control of yiwei kangbao capsules.KEY WORDSYiwei kangbao capsules；Tetrahydropalmatine；Chromatography,thin layer ; Chromatography,high pressure liquid（Notes: Yiwei kangbao capsule is composed of Rhizoma Corydalis，Radix Angelicae Sinensis, Rhizoma Sparganii, etc..）
  • 药品质量控制
    A Study of the Quality Standards of Xiaojie Paint
    MA Pingbo;MA Rui;HOU Lianbing
    2007, 26(6): 663-665.
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    ABSTRACTObjectiveTo probe into the quality standards of xiaojie paint. MethodsThe qualitative identification of Radix paeoniae Rubra, Rheum palmatum and Radix Scutellariae baicalensis in xiaojie paint was carried out with thin layer chromalography (TLC). The content of forsythol was determined with dualwavelength TLC scanning with a detection wavelength (λs) of 440 nm and a reference wavelength (λr) of 700 nm.ResultsThe average rate of recovery of the forsythol was 101.13%, with an RSD of 1.42%.ConclusionThe method for the determination of the content of forsythol in the xiaojie paint with dualwavelength TLC scanning was handy, quick and accurate. KEY WORDSXiaojie paint； Chromatography,thin layer； Forsythol（Notes: Xiaojie paint is composed of forsythol, Paeonia Rubra, Rheum officinale Baill , Radix Scutellariae, borneol etc..）
  • 药品质量控制
    Content Determination of Paeoniflorin in Fufang Chuanji Tablets with HPLC
    LU Yi;GAO Shenrong;CHEN Huating;LU Jinqing
    2007, 26(6): 665-666.
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    ABSTRACTObjectiveTo develop a HPLC method for the determination of the content of paeoniflorin in fufang chuanji tablets.MethodsPaeoniflorin was separated on a Symmetry C18 column(5 μm ，3.9 mm×150 mm ) with the use of isopropanolmethanolacetic acidwater(1：23：1：75) as the mobile phase. The flow rate was 1.0 mL·min1 ,the column temperature was 35 ℃ and UV detection wavelength , 230 nm. Results Paeoniflorin was well separated from the other comporents of the tablets. The linear range of concentration of paeoniflorin was 0.204 8－1.024 0 μg, the correlation coefficient r=0.999 3,the average rate of recovery was 98.6%（n=6）, RSD=0.835%, (n=6). ConclusionThe method was shown to be handy , accurate and well reproducible in the content determination of paeoniflorin in fufang chuanji tablets.
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