中国科技论文统计源期刊 中文核心期刊
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
ObjectiveTo study effects of rhizoma dioscoreae hypoglaucae on the uric acid elimination. Methods70 mice were randomly divided into 7 groups: normal control, model control, benzbromarone group, high and low dose of water extract and ethanol extract of Dioscorea collettii Hook.Var, respectively, 10 in each group. Mice in normal control and model group were orally treated with 0.02 mL·g-1 N.S., others were i.g. benzbromarone 0.03 g·kg1, water extracts 10 and 20 g·kg1, and ethanol extract of Dioscorea collettii Hook.Var 10 and 20 g·kg1, respectively. Mice were treated once at 8：00 and 16：00 every day, for five consecutive days. Except for normal control group, others were i.p. injected with monosodium urate suspension 0.025 mL·g-1 after the last treatment to induce hyperuricemia. The blood samples were collected from eye balls at different time after the model construction, and isolated the serum to detect uric acid by uric acid analysis regent kits. ResultsIt was shown that the high dose of water extract significantly reduced the uric acid in the serum of both rats and mice, which similar to benzbromarone. ConclusionRhizoma Dioscoreae Hypoglaucae exhibits antigout function.
