中药与天然药物专栏
SHAO Ziqiang;JIAO Jingsong;XUE Shuang;WANG Guoxiang
2006, 25(6): 0-0.
ObjectiveTo study the clinical effect of puerarin injection in the treatment of patients with cerebral infarction. Methods7 600 inpatients with cerebral infarction serving as the subjects of the study were subjected to basic medical treatment including antiplatelet drugs, dehydration, antiinfectives, control of blood pressure, blood glucose, blood lipids, etc.. Of these, 2 500 patients were given each 500 mL of puerarin injection q.d., 2 000 patients were given each 400 mL of red sage root injection q.d., another 2 000 patients were given each 450 mL of total notoginsenoside injection q.d.. All these drugs were administered by intravenous instillation. The remaining 1 100 patients serving as controls were not given additional special treatment. The course of treatment in all these patients lasted 21 days. The effective rate, extent of nervous function improvement,case fatality rate and incidence of postinfarction cerebral hemorrhage(CH) in patients of the different groups were compared. ResultsThe overall effective rates in patients treated with puerarin, red sage root, total notoginsenoside and those serving as controls were 79.20%,78.50%,60.15% and 36.00%, respectively, the difference between the effective rates of the puerarin group and notoginsenoside group being significant(P<0.05)and that between the puerarin group and control group, highly significant(P<0.01). The extent of nervous function improvement in patients of the puerarin group was significantly greater than that of red sage root group(P<0.01) and control group (P<0.01) but similar to that of the notoginsenoside group(P>0.05). The case fatality rate in patients of the puerarin group(1.40%) was significantly lower than those of the notoginsenoside group(2.40%,P<0.05), red sage root group (3.60%,P<0.01) and control group (8.18%,P<0.01). The incidence of CH in patients of the puerarin group (2.40%) was higher than that of the control group (1.10%,P<0.01), lower than that of the notoginsenoside group(5.00%,P<0.05) and similar to that of the red sage group (2.55%,P>0.05). ConclusionPuerarin injection was shown to strikingly improve the nervous function and reduce case fatality rate in the treatment of patients with cerebral infarction.