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    药物研究
  • 药物研究
    XIA Liu;LIU Qiangni;GONG Peili
    2006, 25(11): 1109-1111.
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    To observe the protective effects of dauricine on cardiac hypertrophy induced by thyroxine in rats. MethodsCardiac hypertrophy model of rats was induced by intraperitoneal injection of thyroxine. Several doses of dauricine and verapamil were intraperitoneally injected when the model was formed to search the effect of dauricine or verapamil on the fibrosis and oxidative index of hypertrophic cardiac muscle. ResultsDauricine could depress the fibrosis and cell hypertrophy of hypertrophic cardiac muscle, and reduce the heart weight index(P<0.01), reduce the activities of CK and LDH in blood and content of MDA in cardiac muscle, and increase the activities of SOD in cardiac muscle(P<0.05). ConclusionDauricine can effectively reduce the fibrosis of cardiac hypertrophy and enhance the ability of anti oxidant in heart tissue.
  • 药物研究
    WU Weiming;CHEN Lijia;BAO Shihui
    2006, 25(11): 1112-1113.
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    To observe the cardiac functional effect of doxofylline(DL) on experimental animal. MethodsThe myocardial contractive force(MCF) and heart rate(HR) in isolated heart were investigated in toad and guinea pig by perfusing various concentrations of DL and theophylline(TL)respectively. ResultsOn isolated toad heart, MCF was significantly weaker in DL group than TL group at the concentrations ranging from 5×107 to 5×103 mol ·L1 (P<0.01 or P<0.05); On isolated guinea pig heart, MCF was significantly weaker in DL than TL at the concentration range from 1×107 to 1×103 mol ·L1 (except 1×107 mol·L1 ) (P<0.05). Once the maximal MCF was reached, the excitations of MCF in two groups were gradually decreased with the increasing concentrations or even became inhibitive. At certain concentrations, both DL and TL induced mild HR increase and arrhythmia in some specimens, with no significant difference between two groups (P > 0. 05). ConclusionWithin a definite range of concentrations, DL could excitate the contraction of cardiac muscle, but the effects of DL are weaker than that of TL.
  • 药物研究
    GONG Xinjiang;DING Hong;QIU Yinsheng;JIA Zhenrong;QU Wen;HE YingGONG Xinjiang;DING Hong;QIU Yinsheng;JIA Zhenrong;QU Wen;HE Ying
    2006, 25(11): 1114-1115.
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    To observe the toxicity of cyclophosphamide(CP) on primary cultured hepatocytes and the protective effects of Oleanolic acid(OA).MethodsRat hepatocytes were isolated for primary culture and intracellalar ALT、AST and LDH leakages were detected in supernatant and MTT assay was used to evaluate the toxicity of CP and the protective potent of OA. ResultsCP increased the leakages of ALT,AST and LDH from hepatocytes with decreased the MTT value of hepatocytes. These changes were ameliorated partly by OA. ConclusionOA can protect hepatocytes from CP induced damage.
  • 药物研究
    LI Jihong;ZHANG Tong;DAI Dongmei
    2006, 25(11): 1116-1117.
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    To observe the safety of diclofenac diethylamine salt gel after external use. MethodsAcute dermal toxicity test and dermal irritation test were conducted in rabbits, and dermal sensitivity test was performed in guinea pigs. ResultsDiclofenac diethylamine salt gel had no acute toxicity to the skin of rabbits with no stimulating action to the intact skin, but with a mild stimulation to the broken skin. Skin allergic reactions didn’t appear in guinea pigs. ConclusionDiclofenac diethylamine salt gel is safe for transdermal administration.
  • 药物研究
    ZHANG Yu;MA Li;CHEN Wen;ZHANG Yuliang;ZHENG Ni;ZHANG Songan;CHEN Dongsheng;CHEN Huating
    2006, 25(11): 1118-1120.
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    To study the optimum technics of extracting Flos Lonicerae polysaccharide. MethodsThe factors affecting the extraction of Flos Lonicerae polysaccharide were studied by Orthogonal test, and the relative percentage content of Flos Lonicerae polysaccharide was studied with sulfuric acidphenol method. ResultsThe optimum technic of extracting Flos Lonicerae polysaccharide was as follows: water permeating time 2 h, temperature of water 90 ℃, extraction with chloroform once, concentration of alcohol 80%。ConclusionThis method is the optimum technic for extracting Flos Lonicerae polysaccharide,providing a basis for its further study.
  • 药物研究
    NING Yuming;LIU Xiaoyu;LIANG Wenquan
    2006, 25(11): 1121-1122.
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    To prepare anemonin patches with higher transdermal flux in order to provide proof for the development of anemonin transdermal preparation. MethodsThe adhesivematrix type patches were prepared by salivate technology with Eudragit E100 as adhesivematrix material. The reservoir patches were prepared by hotenvelop method with HPMC ethanol gel as reservoir medium and EVA as control release membrane. The in vitro penetration experiments were performed using human skin on TK6A diffusion instrument. The concentrations of drug in receptor compartment at different time spots were determined by HPLC. The flux and other parameters were evaluated. ResultsThe stable flux of anemonin permeating through human skin from adhesivematrix type patches of anemonin was(1.72±0.02) mg·(cm2)1·h1 ,which was 1.47 and 2.30 times higher than that from its saturated water solution and reservoir patches respectively. ConclusionThe adhesivematrix type patch is effective for transdermal delivery of anemonin with simple preparation, which has the potentiality to develope to a new transdermal preparation of anemonin.
  • 泌尿系统与男科用药专栏
  • 泌尿系统与男科用药专栏
    YIN Chunping;CHEN Zhi;SHI Long;LIU Jihong
    2006, 25(11): 1138-1140.
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    To study the effects of extracts of acanthopanacis senticosi combined with astragali on in vitro human sperm mobility in patient with asthenospermia . MethodsBy using computerassisted sperm analysis (CASA), the effects of different proportional extracts of acanthopanacis senticosi and astragali were observed on human sperm mobility in vitro. The sperm obtained by masturbation and prepared by swimup technique from 30 patients with asthenospermia was incubated in different volume proportions of acanthopanacis(10 mg·mL-1):astragali(20 mg·mL-1)(4:1, 2:1, 1:1, 1:2 and 1:4 ). Measurements were carried out at 15, 30 and 60 minutes of incubation in all specimens with CASA.Results Different proportional extracts of acanthopanacis senticosi and astragali can increase in vitro human sperm mobility in patient with asthenospermia. Compared with control group, the difference of percentage of viability (Mot), percentage of progressive mobile sperm [(A+B )%], the curvilinear velocity (VCL), the straight line velocity (VSL) and average path velocity (VAP) was significant(P<0.05). The effects of 1:1 volume proportion were the most obvious among all. ConclusionCombination of acanthopanacis senticosi with astragali can significantly improve the in vitro human sperm mobility in patient with asthenospermia.
  • 泌尿系统与男科用药专栏
    CHEN Zhi;LIU Jihong;YIN Chunping
    2006, 25(11): 1141-1143.
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    To study and Compare the effects of organic solvents on human sperm mobility in vitro . Methods By using computerassisted sperm analysis(CASA), the effects of methyl sulfoxide, glycerol, Macrogol 400 and Tween 80 were oobserved on human sperm mobility in vitro. The sperm obtained by masturbation and prepared by swimup technique from 25 men was incubated in methyl sulfoxide, glycerol, Macrogol400 and Tween80 in different concentration. Measurement were carried out at 15, 30,45 and 60 minutes of incubation in all specimens.ResultsWith time to be extended, high concentration of methyl sulfoxide, glycerol, Macrogo l 400 and Tween 80 could decrease human sperm mobility. They could decrease the percentage of viability (Mot), percentage of progressive mobile sperm, the curvilinear velocity (VCL), the straight line velocity (VSL) and average path velocity(VAP). Compared with control group, the difference was significant (P<0.05). ConclusionHigh concentrations of organic solvent inhibit human sperm motility and mobility in vitro. The study provides new experimental basis for research of different drugs on sperm.
  • 泌尿系统与男科用药专栏
    WU Jinhu;WANG Gang;ZHANG Xiaoyan;XIAO Yuqing;WANG Linhai;YU Huibin;LI Hongliang
    2006, 25(11): 1144-1145.
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    To investigate the therapeutic effect and mechanism of qianyu on chronic prostatitisMethodsThe pathological models of chronic bacterial prostatitis(CBP) and nonbacterial prostatitis were respectively established by injecting standard E. Coli and carrageenan into the rat's prostate. And the two models were respectively treated with qianyu treatment group and qianlietai control group to observe its effect. The immunity in the rat's prostate(SIgA and IL8) was examined by IR and ELISA. ResultsAs compared the treatment of qianyu on CBP model with the model control group, there were respective significant differences (P<0.05) in the level of SIgA and IL8 between the two groups. ConclusionQianyu may markedly improve the local immunity in CBP model of rat's prostate. It has the effects of repairing prostatic tissue, and alleviating mesenchymal inflammatory reaction. The effect of qianyu to regulate the local immunity in the rat's prostate may be its mechanism in the treatment of chronic prostatitis.
  • 泌尿系统与男科用药专栏
    LIU Feng;ZHANG Genfu;JI Xining;HUANG Chibing;WANG Pingxian;FAN Mingqi
    2006, 25(11): 1146-1148.
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    To study the renoprotective effect of valsartan on patients with chronic allograft nephropathy (CAN). MethodsPatients with CAN were randomly divided into two groups. In the control group (n=21) only immunosuppressive agents were adjusted, and in the therapy group (n=21) the patient would additionally take valsartan. Patient’s clinical and biochemical parameters were recorded before treatment and at the 3 rd, 6th, 9th, and 12th month followup after treatment. Before treatment and at the end of followup visit, the expressions of TGFβ1 in renal allograft were detected. ResultsIn the therapy group, the patient’s clinical and biochemical parameters were improved, including decreased Scr,decreased MAP, decreased urine protein and decreased concentration of urine TGFβ1(all P<0.01). In the control group after therapy, there was a slowing down of serum creatinine ascending rate with other biochemical parameters changed insignificantly. The expression of TGFβ1 in allograft decreased significantly in the therapy group(P<0.05) but changed insignificantly in the control group. ConclusionValsartan has a high therapeutic renoprotective effect on renal transplant patients.
  • 药物与临床
  • 药物与临床
    YANG Xiangdong;XIONG Shengdao;LIU jin;ZHAO Jianping;LIU Xiansheng
    2006, 25(11): 1149-1151.
    To evaluate the clinical efficacy and safety of an injectable cefmenoxime for the treatment of acute lower respiratory tract bacterial infections.MethodsSingleblind and parallelism randomized clinical study was conducted to compare the efficacy and safty of home made cefmenoxime with Bestcal,imported cefmenoxime altogther ,24 patients were enrolled in the study ,12 were in cefmenoxime group (treatment group),other 12 were in Bestcall group as the contraol(in this group, one example was discontinued because of rash),the dose was 1 g ,adder to 100~250 mL Nacl Solution,iv drip for 30 min1 h ,bid, for a course of 710 d. Resultsat the end of treatment ,the cure rates and effective rates were 100.0% and 100.0% in cefmenoxime group ,and 91.6% and 100.0% in Bestcall group respectively.The bacterial eradication rates were 100.0% and 91.6% in the two groups respectively.There were no statistically significant difference between the two groups. Adverse reaction rash observed in 8.33%(1/12) in the control group. ConclusionHome made injectable cefmenoxime is effective and safe for the treatment of scute moderate and severe bacterial infect
  • 药物与临床
    YAN Chunling;ZUO Mingzhang
    2006, 25(11): 1152-1154.
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    To observe the analgesic effect and the sideeffect of sufentanil with different basal volumes used for PCIA. MethodsSixty ASA I~II patients (32 male,28 female) aged 2070 year weighing 4598 kg undergoing elective thoracal or abdominal surgery under general anesthesia were separated into three groups randomly receiving PCIA with sufentanil 0.001 μg·kg1·min1 (S1,n=20),0.000 5 μg·kg1·min1(S2,n=20), 0 μg·kg1·min1 (S3,n=20). PCA 1 mL (sufentanil 2 μg·mL1) was used in three groups with a 5 min locktime through patientcontrolled analgesia device。 Visual analogue scale (VAS) scores in quiet and cough,cumulative volumes of the intravenous drugs, vital signs including SPO2,HR, RR, and sideeffect including sedation scores, nausea, vomit, pruritus and other analgesics were assessed after 6, 24 and 48 h of postoperative analgesia. ResultsVAS scores decreased when the basal volumes of sufentanil increased. VAS scores of group S1 were similar to group S2 (P>0.05), lower than group S3 (P<0.05) in quiet , were lower than group S2(P<0.05) and group S3(P<0.01) on movement. The rate of nausea in group S1 were lower than S2. Vital signs including SPO2 、HR 、RR were in the normal range. ConclusionSufentanil 0.001 μg·kg1·min1 can provide satisfying analgesia without increasing the sideeffect .
  • 药物与临床
    HUANG Lei;ZHANG Chi;CHEN Yingqun
    2006, 25(11): 1155-1157.
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    To compare the efficacy and safety of itraconazole with those of fluconazole as earlier empirical antifungal therapy in ICU. MethodsIn a randomized, controlled, open trial, 40 patients with risk factors of systemic fungal infections and unexplained fever that did not respond to broadspectrum antibiotic therapy for 37 days were randomly divided into itraconazole group (20 patients) and fluconazole group (20 patients). Intravenous itraconazole, 200 mg, was administered by infusion every 12 hours for the first 48 hours, followed by 200 mg daily from days 3 to 7. From day 8, oral itraconazole solution, 200 mg twice daily, replaced intravenous itraconazole for another 14 days. Fluconazole was infused intravenously at a daily dose of 400 mg for 21 days. Body temperature, fungal infection, drugrelated adverse events, and the efficacy were investigated. ResultsFor itraconazole and fluconazole, the overall effective rates were 65.0% and 50.0%, and the adverse reactions rates were 30.0% and 5.0% respectively. But there were no significant differences in the overall effective rates and the adverse reactions rates between two groups. Two patients developed deep fungal infections in fluconazole group during the therapy. ConclusionNowadays, itraconazole and fluconazole are effective and safe as the firstline drugs in earlier empirical therapy in ICU. However, itraconazole appears better in efficacy.
  • 药物与临床
    QI Hong;YANG Tianlun;WU Shengbin;JING Shizhan
    2006, 25(11): 1158-1160.
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    To evaluate the therapeutic effect and safety of bisprolol/ hydrochlorothiazide compound tablet on patients with essential hypertension. MethodsIn this randomized controlled clinical trial, after 2 weeks single blind placebo was hout, patients with essential hypertension were randomly assigned to receive bisprolol/hydrochlorothiazide compound tablet 2.5 mg/6.25 mg or bisprolol tablet 2.5 mg once daily for 4 weeks. Doses were added to bisprolol/ hydrochlorothiazide compound tablet 5 mg/6.25 mg or bisprolol tablet 5 mg once daily for another 4 weeks in patients having seated DBP ≥90 mmHg at the end of 4 weeks. Blood pressure, heart rates, symptoms and signs as well as adverse effects were examined and inquired at the end of washout and 2, 4, 6, 8 weeks. Laboratory examinations and electrocardiogram were performed at baseline and the end of the trial. ResultsThirty one essential hypertensive patients were recruited and randomly divided into bisprolol/hydrochlorothiazide compound tablet group (16 cases) or bisprolol tablet group (15 cases) . Twenty nine eligible essential hypertensive patients completed the trial, 16 patients in bisprolol/ hydrochlorothiazide compound tablet group and 13 patients in bisprolol tablet group. At the end of 4 , 8 weeks , systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate(HR) were significantly lowered compared with those at baseline (P<0.01); there was significant difference in the reduction of seated DBP between the two groups (P<0.05). At the end of 8 weeks, there was significant difference in the reduction of seated SBP and the response rate between the two groups (P<0.05) , the response rate being 93.75% in bisprolol/ hydrochlorothiazide compound tablet group and 53.33 % in bisprolol tablet group. Side effects were mild and few with no significant difference between 2 groups. At the end of 8 weeks, no difference was found in laboratory findings compared with those at baseline in the two groups ( P > 0.05). ConclusionBisprolol/hydrochlorothiazide compound tablet 2.5 mg/6.25 mg or 5 mg/6.25 mg once daily is safe and more effective than bisprolol given alone on patients with essential hypertension.
  • 药品质量控制
  • 药品质量控制
    LIU Peng;ZHOU Jun;HE Wei;XIN Chunyan;JIANG Ru
    2006, 25(11): 1197-1198.
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    To describe a simple and rapid HPLCELSD method for the baseline separation, identification and assay of astragaloside IV in huaqitongmai granule .MethodsThe analytical column was a ZODBAXC18(4.6 mm×150 mm,5 μm). The mobile phase was composed of acetonitrilwater(35:65). The flowrate was 0.8 mL·min1. The column temperature was 30 ℃.The injection volume was 20 μL. The temperature of drift tube for ELSD was 105 ℃ and the flow rate of N2 was 2.70 mL·min1. The pressure was 2 BAR. ResultsThe calibration curve was linear over the range of 1.53~7.64 μg (r=0.999 6). The average recovery of the method was 98.6%,and RSD was 1.17% (n=5) . ConclusionThe proposed method would be used in the quantitative analysis of astragaloside IV in huaqitongmai granule and the method is convenient, economical and accurate with good reproducibility.