To study the effect of a small-molecule compound J2 in the inhibition of skin allograft rejection in mice.MethodsC57BL/6 and Balb/c mice were used as donors and recipients respectively for the establishment of a skin allograft model. 45 mice with the model were then randomly divided into 3 equal groups. Mice of group A, B and C were given each placebo,10 mg·kg1 of cyclosporin A and 30 mg·kg1 of J2 administered by gastrogavage q.d., respectively. The course of treatment in the 3 groups lasted 12 days beginning at the day of transplantation. The graft survival time in mice of the different groups was assessed with the KaplanMeier analysis. 14 days after the transplantation, histological examination of the skin graft was carried out.ResultsThe average graft survival time in mice of allograft control (group A) was (13.7±1.4) d. The average graft survival tomes in mice of group B treated with cyclosporin A and mice of group C treated with J2 were (18.2±2.1) d and (17.7±2.4) d, respectively, both of which being significantly longer than that of group A (P<0.01). The difference between the average graft survival times in mice of group B and C, however, was insignificant(P>0.05). Histological examination demonstrated that no apparent lymphocyte infiltration could be found in the skin graft of mice treated with J2 (group C).ConclusionThese results show that J2 can inhibit allograft rejection dramatically.