中国科技论文统计源期刊 中文核心期刊  
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊  
日本科学技术振兴机构数据库(JST)
第七届湖北十大名刊提名奖  

Archive

  • Select all
    |
    药物研究
  • 药物研究
    TANG Xi;HU Ya;HU Guoqing
    2005, 24(9): 0-0.
    Download PDF ( )   Knowledge map   Save
    ObjectiveTo study the anticancer effect of xihuang pill combined with 5fluorouracil (5-Fu) in mice with implanted sarcoma S180.MethodsSixty mice with subcutaneously transplanted sarcoma S180 were randomized into four groups: negative control group treated with sodium chloride injection, ig and ip; xihuang pill group treated with xihuang pill 2.0g·kg-1, ig; 5-Fu group treated with 5-Fu, 0.02 g·kg-1, ip; and xihuang pill plus 5Fu group treated with xihuang pill 2.0 g·kg-1, ig, and 5Fu 0.02 g·kg-1, ip. All the mice received a single dose daily for 7 d. The growth of tumor tissue was observed and the mice were weighed. After the treatment for 7 d, all mice were killed. The tumor tissue was isolated and weighed to analyze the inhibiting rate. ResultsThe inhibiting rate of tumor weight in xihuang pill group, 5-Fu group, and xihuang pill plus 5-Fu group were 28.1%, 35.3% and 55.4%. The tumors in all the treatment groups were significantly smaller than in the negative control group (P<0.05). There was a significant improvement in the combining treatment group than the single drug treatment (P<0.05).ConclusionXihuang pill plus 5-Fu group could inhibit tumor growth more effectively, and there may be a synergetic effect.
  • 药物研究
    ZHANG Junhong;XIAO Junhua;XU Kai;ZHOU Shuang;ZHOU Yin;WANG Jialing
    2005, 24(9): 0-0.
    Download PDF ( )   Knowledge map   Save
    ObjectiveTo study the antiarrhythmic effects of lianxin (Nelumbo nucifera Gaertn.) total alkaloids(TAL) in animals.MethodsThe experimental arrhythmia models were induced by aconitine, ouabain, calcium chloride, chloroform and electricalstimulation, and the antiarrhythmic effects of lianxin total alkaloids were studied.ResultsTotal alkaloids could effectively antagonize the arrhythmias induced by the drugs and electrical stimulation. TAL could increase drug doses in inducing arrhythmia in the animals, and decrease the rate of ventricular fibrillation and the mortality rate.ConclusionTotal lianxin alkaloids have antiarrhythmic action.
  • 药物研究
    ZHU Shaoming;JIN Zhaoxia
    2005, 24(9): 0-0.
    Download PDF ( )   Knowledge map   Save
    ObjectiveTo explore the effect of diammonium glycyrrhizinate on kidney fibrosis in rats induced by guanmutong to provide some theoretical data for the treatment of kidney fibrosis. MethodsEighteen white rats were randomised into three groups evenly: the control group received with nothing, the first group given with guanmutong, and the second group given with diammonium glycyrrhizinate combined with guanmutong. SCr, BUN, serum potassium, serum sodium, and serum calcium; PCⅢ, HA, and LN of radioimmunity data were tested before the experiment and at 2, 3, 4, 5, 6 wk in the experiment. All the rats were killed after 42 d, and their kidney were examined by histomorphology and immunohistochemistry. ResultsThe data in the first group and the second group were significantly higher than in control group (P<0.05 or P<0.01). There was no significant difference between the first group and the second group (P>0.05). ConclusionDiammonium glycyrrhizinate maybe have no treatment effect on acute or chronic kidney injury caused by guanmutong.
  • 泌尿系统用药专栏
  • 泌尿系统用药专栏
    CHEN Feng;LI Shiwen;ZHENG Hang
    2005, 24(9): 0-0.
    Download PDF ( )   Knowledge map   Save
    ObjectiveTo compare the clinical efficacy between pazufloxacin and levofloxacin in the treatment of urinary infection.MethodsSixty patients with urinary tract infection were randomised into two groups evenly (n=30), the pazufloxacin group and the levofloxacin group. The pazufloxacin group were given pazufloxacin 0.3 g iv, bid,and the levofloxacin group levofloxacin 0.2 g iv, bid. The treatment period was 5~14 d. ResultsThe effective rate in pazufloxacin group was 96.4%, and in levofloxacin group 92.6%. The cured rates in pazufloxacin group was 85.7% and in levofloxacin group 70.4%. There was no significant difference between the two groups (P>0.05).ConclusionPazufloxacin has the same efficacy as levofloxacin in the treatment of urinary tract infection.
  • 泌尿系统用药专栏
    YU Xiaoxiang;LV Shengqi;NING Zhifeng;WANG Linglong;ZHANG Jie;YANG Huan;LV Cai
    2005, 24(9): 0-0.
    Download PDF ( )   Knowledge map   Save
    ObjectiveTo observe the effect of naftopidil tablets in the treatment of chronic prostatitis and to study the mechanism in the treatment. Methods136 patients with chronic prostatitis were randomly divided into two groups evenly: the treatment group treated with naftopidil tablets (25 mg, qn) and levofloxacin (0.2 g, bid) and the control group treated only with levofloxacin (0.2 g, bid) for 6 weeks. Prostatic secretion examination (EPS), chronic prostatitis symptom index (CPSI), average flow rate(AFR), maximum flow rate (MFR), maximum urethral closure pressure(MUCP), maximum urethral pressure (MUP) and residual urine (RU) were compared. ResultsThe differences between the two groups were significant in EPS, CPSI, AFR, MFR, MUCP, MUP and RU (P<0.05).ConclusionNaftopidil tablets can lower the intraurethral pressure, reduce intraprostatic urinary reflux and improve the symptoms of chronic prostatitis, especially for those with the symptoms of functional urinary tract obstruction.
  • 药物与临床
  • 药物与临床
    ZHU Xia;WU Yihang
    2005, 24(9): 0-0.
    Download PDF ( )   Knowledge map   Save
    ObjectiveTo evaluate the efficacy, tolerance and safety of moxonidine on aged patients with mild to moderate essential hypertension. MethodsThirtyone patients over seventy with mild to moderate essential hypertension were given moxonidine orally, 0.2-0.4 mg, qd, for 8 weeks. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate and blood glucose of the patients before the treatment and at 1, 2, 4 and 8 wk were tested, and the serum level of K+, Na+, BUN, Cr, AST and ALT before and after the treatment were measured. ResultsThe SBP, DBP and heart rate declined remarkably after 1, 2, 4 and 8 wk. The level of K+, Na+, BUN, Cr, AST, ALT and serum glucose have no significant difference before and after the treatment. The total efficacy rate of moxonidine was 91.7%. Moxonidine had long therapeutic effect with good tolerance. Only one patient had adverse reaction. ConclusionMoxonidine has certain antihypertive effect and good safety on aged patients with mild to moderate essential hypertension.
  • 药物与临床
    SUN Huayu;LIN HaiYan
    2005, 24(9): 0-0.
    Download PDF ( )   Knowledge map   Save
    ObjectiveTo observe the effect of shuxuening injection in treatment of acute cerebral infarction (ACI). MethodsBy randomization, 103 ACI patients were divided into two groups. Fiftytwo patients in the treatment group received shuxuening injection (12 mL) in 5% glucose injection (250 mL), iv, qd; and fiftyone patients in the control group received a mixture of danshen injection (20 mL) in 5% glucose injection (250 mL), iv, qd. All the patients were observed for 15 days. The effect and changes of neurofunction were scored before and after the treatment.ResultsThe effective rate in the treatment group was 90.4%, and in the control group 76.5%. The scores in the treated group was significantly lower than in the control group (P<0.05). ConclusionShuxuening injection is a safe and effective drug in the treatment of acute cerebral infarction, and has clinical value.
  • 药物与临床
    WANG Zhongxi;LI Wenjing;HUANG Aixia;ZHU Rongfei;CHEN Huan;ZHANG Wei;LIU Guanghui
    2005, 24(9): 0-0.
    Download PDF ( )   Knowledge map   Save
    ObjectiveTo compare the effects of specific immunotherapy and conventional therapy in allergic purpura.MethodsFortyseven cases of allergic purpura patients were randomized into two groups: the treatment group (n=30) treated with specific immunotherapy and the control group (n=17 ) treated with conventional conservative therapy. ResultsThe effective rates between the treatment group and the control group had no significant difference (P>0.05), but the recurrence in the treatment group was significantly lower than in the control group (P<0.01).ConclusionThe specific immunotherapy had better and longer effect in the treatment of allergic purpura.
  • 药物与临床
    YANG Tao;WANG Lili;WANG Junlu
    2005, 24(9): 0-0.
    Download PDF ( )   Knowledge map   Save
    ObjectiveTo compare the patientcontrolled analgesia effect and safety between lornoxicam and lappaconitine in aged patients after midepigastric surgery.MethodsSixty patients (ASA Ⅰ-Ⅱ),aged 6578,scheduled to midepigastric surgery were divided into two groups. Group A were given 32-40 mg lornoxicam, and group B 4856 mg lappaconitine, both in 100 mL of 0.9% sodium chloride mjection, iv. The loading doses of 8 mg were injected in both groups. The analgesia effects were valued by visual analog scale (VAS) scores and adverse reactions were noted.ResultsVAS values in group A were significantly lower than that in group B (P<0.05). The adverse reactions between the two groups had no significant difference. ConclusionPatientcontrolled analgesia with lornoxicam or lappaconitine in aged patients after midepigastric surgery is safe and effective. The analgesia effect of lornoxicam is superior than lappaconitine.
  • 药物与临床
    LIU Lingyun;TIAN Yuke
    2005, 24(9): 0-0.
    Download PDF ( )   Knowledge map   Save
    ObjectiveTo observe the caudal block effect of ropivacaine with various concentrations in children. MethodsEighty short perineum surgery pediatric patients were randomized into four groups evenly: R1 group (treated with 0.2% ropivacaine, 1 mL·kg-1), R2 group (treated with 0.25% ropivacaine, 1 mL·kg-1), R3 group (treated with 0.3% ropivacaine, 1 mL·kg-1) and R4 group (treated with 0.375% ropivacaine, 1 mL·kg-1). Ropivacaine was given after 1 mg·kg-1 propofol administrated iv as inducing anaesthesia. Ketamine were given intravenously in necessity. Blood pressure, heart rate, respiratory rate, SpO2, and the dosage of ketamine were recorded during the surgery. Motor power and reflex scale (MPRS) scores and pain/discomfort scale (PDS) scores were tested. ResultsBlood pressure, heart rates, respiratory rate and SpO2 had no significant difference among the four groups. The dosages of ketamine were significantly decreased in the following order:R1 group>R2 group or R3 group>R4 group (P<0.05). The MPRS scores in R2 group and in R3 group had no significant difference. The PDS scores were in the order: R1 group>R2 group or R3 group>R4 group (P<0.05).ConclusionThe results indicate that 0.3% ropivacaine solution is the best in child caudal block with good analgesia and minimal side effects.
  • 药物与临床
    LI Guojun;WANG Weihua;LI Hongtao;QIN Huimin;WU Chunming;SONG Jianxin
    2005, 24(9): 0-0.
    Download PDF ( )   Knowledge map   Save
    ObjectiveTo observe the clinical efficacy of thymosin α1 (Tα1) combined with vidarabine on chronic severe hepatitis.MethodsFortysix chronic severe hepatitis B patients were divided into the treatment group (n=24) and the control group (n=22). The control group were treated with vidarabine, and the treatment group with Tα1 and vidarabine for 8 wk. The serum levels of total bilirubin (TBiL), alanine aminotransferase (ALT), plasma thromboplastin activity (PTA), endotoxin, interleukin and Tlymphocyte subsets were compared.ResultsThe total effective rate and mortality in treatment group were 71.0%, 29.0%, and in the control group were 41.0%, 59.0%. There was a significant difference between the two groups (P<0.05). ConclusionTα1 combined with vidarabine can lessen the harm of liver function by immune reaction and lower the mortality of chronic severe hepatitis B.
  • 药物制剂
  • 药物制剂
    ZHAO Jianzhong;YAN Macheng
    2005, 24(9): 0-0.
    Download PDF ( )   Knowledge map   Save
    ObjectiveTo study the effect of oleic acid microemulsion on the transdermal permeation of lidocaine. MethodsThe phase diagrams were constructed for the formation of oleic acid microemulsion. Transdermal permeation of lidocaine from various vehicles was evaluated with excised rat skins.ResultsOleic acid microemulsion could increase the transdermal influx of lidocaine. The optimum oleic acid microemulsion was formed when labrasol as surfactant and tween 80 as cosurfactant. ConclusionOleic acid microemulsion is an effective carrier for the transdermal permeation of lidocaine.
  • 药品质量控制
  • 药品质量控制
    LONG Yan;QU Fujun;SUN Hua
    2005, 24(9): 0-0.
    Download PDF ( )   Knowledge map   Save
    ObjectiveTo establish a HPLC method for determination of prulifloxacin and of related substances in tablets.MethodsThe stationary phase: Hypersil C18 column (5 μm, 4.6 mm×250 mm); the mobile phase: acetonitrile 0.1% phosphoric acid 1 mol·L-1 pentane sulfonic acid sodium solution (31∶69∶0.2); the flow rate: 0.8 mL·min-1; the detect wavelength: 276 nm; and the column temperature: 35℃. ResultsThe adjuvants in the tablets did not interfered the determination of prulifloxacin. Related substances were completely separated from prulifloxacin. Acid, alkali and oxygen could cause some degradation of the tablets. The degradation products could be separated from prulifloxacin, and did not interfered the determination. Within the concentration range of 5~500 μg·mL-1, peak area (A) had good linearity with concentration (C) (r=0.999 9). The average recovery was 99.40%(n=9); and the intraday and betweenday RSD<0.5%. The RSD within 24 h was<0.5% when the solution was stored at room temperature.ConclusionThis method is simple, easy, accurate and specific, and can be used in the determination of prulifloxacin and of related substances in tablets.
  • 用药指南
  • 用药指南
    HU Suping;YU Changping;WU Xiaojun;YANG Jiong
    2005, 24(9): 0-0.
    Download PDF ( )   Knowledge map   Save
    ObjectiveIn order to use antibiotics more rationally, we investigated the bacteria and their antibiotic resistance in lower respiratory tract infections in hospital. MethodsStandard microscopy, culture and drug sensitivity were performed with the bacteria of sputum samples collected from inpatients with lower respiratory tract infections from July 1998 to December 2002. ResultsThere were 888 strains isolated. The Gram positive rate was 20.9%, mainly composed of streptococcus pneumoniae (9.2%). The Gram negative rate was 79.1%,mainly composed of heamophilus influenzae (12.3%), pseudomonas aeruginosa (17.2%) and Klebsiella pneumoniae (11.3%). The resistance rates of the streptococcus pneumoniae to penicillin and erythromycin were 38.9% and 76.7%. The resistance rates of heamophilus influenzae to ampicillin, cefuroxime, cefotaxime and ciprofloxacin were 48.5%, 14.3%, 14.0% and 39.8%. The resistance rates of Klebsiella pneumoniae to ampicillin, ciprofloxacin and amoxicillinclavulanate were 98.8%, 28.1% and 31.9%. The resistance rates of pseudomonas aeruginosa to ciprofloxacin, ceftazidime and imipenem were 25.5%, 28.4% and 24.0%. ConclusionThe antibiotic resistance of the bacteria in lower respiratory infections suggests we must be aware of the bacteria resistance to avoid the irrational use of antibiotics, and we must adjust the therapy regimen by drug sensitivity to the pathogen bacteria.