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    药物研究
  • 药物研究
    Effect of Tetramethylpyrazine Injection on Proliferation of Glomerulus Mesangium Cells in Rats
    XIAO Jianwu;YI Zhuwen;WU Xiaochuan
    2004, 23(9): 611-0613.
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    To explore the inhibitory effect of tetramethylpyrazine (TMP) on proliferation of glomerulus mesangial cells (GMCs) in rats. Methods:Rat GMCs lines were cultured in vitro, Lipoplysaccharide (LPS) and TMP with different concentration were added in the culture medium. There were three experimental groups, GMCs＋LPS＋TMP，GMCs＋LPS, and GMCs named as group TMP，LPS and GMCs, respectively. GMCs proliferative rate was determined by MTT. Results:In TMP group，the GMCs proliferative rate were significantly lower than in LPS group or in GMCs group (P＜0.01).Conclusion:It suggests that TMP can effectively inhibit the proliferation of GMCs.
  • 药物研究
    Effect of Bushenkangshuai Mixture on Pituitarysexual Gland Axis
    L Shengqi;ZHAN Bingyan;ZHANG Xiaobin;ZHANG Jie;JIN Huamin
    2004, 23(9): 613-0615.
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    To study the effect of bushenkangshuai mixture on pituitarysexual gland axis. Method:Bushenkangshuai mixture was given to the male rats orally for one month. Then the plasma testosterone, LH and FSH in the rats were assayed by RIA, and the histological changes in pituitary,adrenal gland and accessory sexual gland were checked.Results:Bushenkangshuai mixture markedly increased plasma level of androgen and improved the function of accessory sexual glands, seminal vesicles and prostate, in castrated rats. But there was no or little effect in normal rats. Conclusion:Bushenkangshuai mixture may be used as androgen replacement therapy in male hypogonadism.
  • 药物研究
    Renoprotective Effect of Lasartan on Early Diabetic Nephropathy in Rats
    YANG Dingping;JIA Ruhan;DING Guohua;JIANG Shiqin
    2004, 23(9): 615-0618.
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    To investigate the renoprotective effect of losartan on early diabetic nephropathy in rats. Methods:Thirty rats were evenly randomisided into three groups: normal control group (N); diabetic rats group (D); the losartan treated diabetic rats group (T). After developing DM, the T group were fed with losartan dissolved in drinking water 250 mg·L1. At the 4th and 8th weekend, Ccr, TP (24 h)1 were tested. And all the rats were killed at 8th weekend, kidney samples were checked by light microscopy, electron microscope, and immunohistochemical staining. TGFβ、NO and SOD in the cortex and in medulla were tested. Results:At the 4th and 8th weekend, Ccr, TP 24 h1 decreased significantly in group T compared with group D; TGFβ in renal cortex and in medulla also decreased significantly in groupT than group D, NO and SOD in the cortex and medulla of groupT were higher than in group D. The pathological changes in group T were ameliorated significantly than in group D. Conclusion:Losartan can improve significantly the renal hemodynamics, inhibit TGFβ expression, increase the presentation of NO and SOD . It also improve the renal pathological changes.
  • 药物研究
    Effects of Ropivacaine and Bupivacaine on Expression of cfos Gene during Global Myocardial Ischemia Reperfusion
    ZHANG Chi;WANG Yanlin;WAN Dening
    2004, 23(9): 620-0622.
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    To observe the effects of bupivacaine and ropivacaine on expression of cfos gene during global myocardial ischemia reperfusion. Methods:Fourty rabbits were randomised into four group evenly: the control group, the IR group (reperfusion for 30 mins after ischemia for 30 mins), the BUP group (bupivacaine was added during reperfusion), the ROP group (ropivacaine was added during reperfusion). Total cellular RNA was extracted after 30 mins of ischemia and reperfusion. And the mRNA of cfos gene was tested by optical density (OD). Results:The absorbance values by mRNA of cfos gene in N, IR, ROP, and BUP groups are respectively (1.842±0.063), (11.855±1.257), (18.736±1.875), (59.647±2.336). The values in both ROP and BUP groups increased significantly than in IR group(P＜0.01).Conclusion:The expression Cfos gene may be existed during ischemiareperfusion period. The cardiotoxicity of Bupivacaine and Ropivacaine related Cfos probably. The cardiotoxicity of ropivacaine is much less than of bupivacaine.
  • 药物研究
    Effect of Moxifloxacin on Pharmacokinetics of Theophylline in Rabbits
    DENG ziyu;XING Rong;HUA Jian;CHEN Gende;LIU Xiaodong
    2004, 23(9): 622-0625.
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    To investigate the effect on the pharmacokinetic parameters of theophylline by moxifloxacin.Methods:In selfcontrol design with rabbits, the plasma concentrations of theophylline were determined after intravenous dose 10 mg·kg1 of theophylline alone. Seven days later, moxifloxacin was administrated orally 20 mg·kg1 once daily for 6 d. Then determine the plasma concentrations of theophylline after intravenous dose 10 mg·kg1 of theophylline again. The pharmacokinetic parameters of theophylline were calculated. Results:The pharmacokinetics of theophylline used alone and coadministered with moxifloxacin were fit to one compartment model. The pharmacokinetic parameters of theophylline used alone and coadministered with moxifloxacin are as following, K：(0.162±0.057)，(0.158±0.059) h1；t1/2：(4.79±1.85)，(5.16±2.26) h；V：(0.524±0.109)，(0.516±0.114) L·kg1；AUC0～10：(97.39±12.40)，(101.27±16.49) mg·h·L1；CL：(0.081±0.018)，(0.077±0.021) L·kg1·h1；Cmax：(20.09±3.77)，(20.53±4.21) mg·L1。There were no statistical significance between pharmacokinetic parameters of theophylline used alone and coadministered with moxifloxacin(P＞0.05). Conclusion:Moxifloxacin has little influence on the plasma concentration and pharmacokinetic parameters of theophylline.
    • 代谢性疾病用药专栏
  • 代谢性疾病用药专栏
    Prevention of Renal Ischemia Reperfusion Injury by Diammonium Glycyrrhizinate after Cardiac Operation
    ZHU Shaoming;LUO Qiang;JIN Zhaoxia;ZHOU Juan
    2004, 23(9): 628-0630.
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    To observe the preventive effects tonium glycyrrhizinate. Methods:The suitable 140 cardiac postoperation patients were divided into the treatment group (n＝72) and the contol group (n＝68). The preparation and other drugs used before the operation were almost the same but the intravenous infusion of 150 mg diammonium glycyrrhizinate dissolved in 5% glucose injection. Also, the same dose of diammonium glycyrrhizinate were used daily in the operating day, fourtyeight hours and seventytwo hours after operation in the treatment group. Urine capacity, BUN, Cr, LDH before and after operation were determined. Results:Urine capacity in treatment group increased more than in the control group not significantly. BUN, Cr, LDH in treatment group lowered significantly than in the control group (P＜0.01).Conclusion:Diammonium glycyrrhizinate can prevent acute kidney failure in cardiac postoperation patient.
  • 代谢性疾病用药专栏
    Observation of the Effectiveness of Naftopidil in the Men with Lower Urinary Tract Symptoms
    LUO Maohua;LI Shiwen;ZHENG Xinmin;HU Liquan;ZHENG Hang
    2004, 23(9): 630-0632.
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    To evaluate the clinical effects and safety of naftopidil in treating the men with lower urinary tract symptoms (LUTS). Methods:Fourtyeight patients with LUTS were divided into two groups by the symptoms: twentyfive cases with voiding symptoms and twentythree cases with storage symptoms. Both groups were given naftopidil 25 mg, po, qd, for 4 weeks. The effects were evaluated by the international prostate symptom score (IPSS), maximum flowrate (Qmax), quality of life (QOL), and residual urine (Ru). Results:In the two groups the changes of IPSS, Qmax, QOL, Ru were significantly different after treatment than before (P＜0.01). There were no significant difference between the groups (P＞0.05) except the IPSS. The IPSS of the storage symptoms group improved significantly than of the voiding symptoms group (P＜0.05). Conclusion:Naftopidil is safe and effective in treating LUTS and has better efficacy inteating the storage symptom than treating the voiding symptom.
  • 代谢性疾病用药专栏
    Effect of Valsartan Combined with Captopril on Refractory Hypertension in Uremia Patients
    YOU Tianlu;HE Yani;YOU Xiaoli
    2004, 23(9): 632-0634.
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    To study effect of valsartan combined with captopril on refractory hypertension in uremia patients.Methods:Thirty suitable patients were evenly randomised into three groups: Group A received valsartan and captopril of sustainedrelease tablets, group B only valsartan; and group C captopril of sustainedrelease tablets. All three group took nifedipine and betaloc before the treatment. The doses of the drugs is separately: captopril sustainedrelease tablets, 37.5 mg qd, valsartan, 80 mg qd; nifedipine 10 mg tid, betaloc 50 mg tid. The changes of blood pressure, the plasma ET1 at 6 AM, and the echocadiagram among three groups before treatment and 4 weeks after the treatment. Results:Blood pressure and the plasma ET1 at 6 AM and E/A of three groups decreased significantly after the treatment(P＜0.01). The decrease of blood pressure, the plasma ET1 at 6 AM and E/A in group A was significantly different from that in group B and in group C(P＜0.01). Conclusion:Both captopril sustainedrelease tablets and valsartan are effective, and the combining use of the two drugs is effective on refractory hypertension in uremia patients.
    • 药物与临床
  • 药物与临床
    Epidural Analgesia Comparison of Ropivacaine with Different Concentration after Lower Abdomen Surgery
    TANG Chunlin;ZHU Zhirong
    2004, 23(9): 645-0647.
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    To compare epidural analgesia effects of ropivacaine with different concentrations after lower abdomen surgery. Methods:Sixty patients (ASAIII) scheduled to lower abdomen surgery were divided into three groups evenly: group A was treated with 0.2% ropivacaine, group B with 0.25% ropivacaine, and group C with 0.125% bupivacaine and morphine 6mg disolved in 60 mL sodium chloride injection. The analgesia effects in the three groups were valued by visual analog scale (VAS) scores at rest (RVAS) and at coughing (CVAS). The moving blockage of lower limbs (modified Bromage scale scores), blood circulation, and adverse drug reaction were observed. Results:There was no significant difference in VAS scores at rest among three groups. VAS scores in group B at coughing was lower than that in group A and C. The rate of lower limbs being weak in group B was 55%; none in group A and C. The rates of nausea and vomiting, of dizziness and of itch respectively were 40%, 55% and 35%; none in group A and B. Conclusion:Epidural analgesia with ropivacaine after lower abdomen surgery is effective, and 0.2% ropivacaine is better and safer than 0.25% ropivacaine.
  • 药物与临床
    Study of Calcium and Active Vitamine D3 on Bone Mineral Density and Bone Metabolic Markers in Old Male Osteoporosis Patients
    WU Wen;ZHI Ximei;LI Yinglan;HAN Meiqing
    2004, 23(9): 647-0649.
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    To investigate the therapeutic effect and safty of calcium agent and active vitamine D3 in old male osteoporosis patients. Methods:The diagnosed osteoporosis patients were randomised into two groups: forty patients in group A as the control group, forty patients in group B as the treatment group. Group A took caltrateD (containing calcium 600 mg and vitamin D 125 U) daily; group B took the same dose of caltrateD and alfacalcidiol daily for 12 mo. The bone mineral density (BMD) of lumbar vertebra (L24) and femoral neck were determined repectively before and after the treatment. Serum osteocalcin (BGP), isomeric Ctelopeptide of type I collagen (βCTX), calcium, phosphorus, liver function and renal function were also measured. Results:After the treatment the BMD of lumbar vertebra (L24) and femoral neck, serum BGP, and serum βCTX in group B were significantly increased (P＜0.01). In group A, the BMD of femoral neck was significantyly decreased (P＜0.01), and serum βCTX was also significantly increased (P＜0.05), but the BMD of lumbar vertebra (L24) and serum BGP had no changes. In both groups liver function and renal function remained normal.Conclusion:Calcium agent administered with active vitamine D3 may effectively prevent and treat osteoporosis in old male patients. And simple calcium agent can not effectively prevent the bone loss.
  • 药物与临床
    Effect of Single Dose Intravaginal Administion of Misoprostol on Cervical Ripening
    XIE Shouzhen;WANG Jing;PENG Yuhong;WANG Tao
    2004, 23(9): 649-0651.
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    To explore the cervical ripening effect by single dose of 50 pg misoprostol administered intravaginally in prolonged pregnant women. Method:One hundred and fortysix women with cervical Bishop score of 6 or less, whose pregnancy were 41 wk or more, were divided into the treatment group (n＝76) and the control group (n＝70). The treatment group were treated by placing misoprostol into the posterior fornix, and the control group treated with placebo. The change in Bishop score eihgt and twentyfour hours after the treatment, the time from medication to labor, the number of vaginal delivery within 24 h, neonatal weights, and APGAR score were observed. Oxytocin was applied if delivery didn't occur 48 hours after the treatment. Results:Sixty patients (78.9%) in the treatment group and 6 patients (8.6%) in control group achieved cervical ripening within 8 h (P＜0.01). Sixtyfive patients (85.5%) in the treatment group and seven patients (10%) in control group achieved cervical ripening within 24 h (P＜0.01). Time from treatment to labor was (12.9±7.8) h in the treatment group, and (52.3±4.4) h in control group (P＜0.01). Vaginal delivery rate within 24 hours was 60.5% (46/76) in the treatment group and 5.7% (4/70) in control group (P＜0.01).Conclusion:The single dose of 50pg misoprostol administered vaginally is effective for the cervical ripening and labor initiation, and has no adverse effects.
  • 药物与临床
    Efficacy of Berberine Combined with Ofloxacin on Acute Bacillary Dysentery in Infants and Children by Retentional Enema Treatment
    CHENG Shuquan
    2004, 23(9): 651-0653.
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    To observe the clinical effect of berberine combined with ofloxacin on acute bacillary dysentery in infants and children by retentional enema treatment, and to find a cheap, effective method for some hardtocure patients. Methods:All the suitable cases (n＝182) with acute bacillary dysentery were randomised into three groups: A, B, and C. And the group A, groupB, and group C were treated by berberine plus ofloxacin retention enema, berberine plus refampicin retention enema, and cephazolin venous transfusion respectively. All three groups were treated for 3－5 d.Results:The cured rates of group A, group B, and group C were 72.6%, 54.2%, and 27.9% respectively, and the bacterial clearance rates 75.8%, 55.9%, and 23.9% respctively. Conclusion:The treatment by berberine combined with ofloxacin has a short period, better efficacy, simplity, and low cost.
  • 药物与临床
    Effect Comparison between Risperdal and Haloperidaol for Tourette Syndrome
    CHEN Huajun;YU Hong
    2004, 23(9): 654-0655.
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    To study the effectiveness and the side effects of risperdal in the treatment of children and adolescents with Tourette syndrome. Methods:A total of thirtynine outpatients with the age of 7－14 years were diagnosed by CCMDIII standard as Tourette syndrome patients, and randomized into two groups. Twentyone patients in group one were treated wtih risperdal, and eighteen patients in group two with haloperidol as the control for a period of 4 weeks. All the patients were also provided psychological therapy. Results:The effective rates had no significant difference between risperdal group (85.7%) and haloperidol group (83.3%) (χ2＝0.042, P＞0.05). Only two patients in risperdal group lost contact, and four patientts were slightly restless. In control group, two cases lost contact, six cases were sleepy, and five cases were restless and slow. The side effects had significant difference between the two groups (χ2＝7.70, P＜0.01). Conclusion:Both risperdal and haloperidol are effective in treatment of tourette syndrome but risperdal has less side effects.
  • 药物与临床
    Effect of Strong NeoMinophagen C on Chronic Hepatitis B in Pregnant Patients
    YANG Junchao;REN Chaofen;LOU Xiaohui;TU Jianguo;XU Wei;WANG Jiyun;WU Jian
    2004, 23(9): 656-0657.
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    To evaluate the therapeutic efficacy of Strong neominophagen C (SNMC) on chronic hepatitis B in pregnant patients.Methods:Sixtythree pregnant chronic hepatitis B patients were divided into two groups: the treatment group (n＝33) and the control group (n＝30). The treatment group received SNMC injection 80ml daily for four weeks, and the control group diammonium glycyrrhizinate injection 150 mL daily for four weeks. Results:The total effective rate was 87.9% in the treatment group and 83.3% in the control group (P＞0.05). The side effects were not found.Conclusion:SNMC injection and diammonium glycyrrhizinate injection have similar therapeutic efficacy in treating pregnant chronic hepatitis B patients.
  • 药物与临床
    Bicyclol in the Treatment of 43 Cases of Chronic Hepatitis B
    CHEN Renhong;ZHANG Jingliang
    2004, 23(9): 658-0660.
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    To explore the clinical efficacy and the side effects of bicyclol in treating chronic hepatitis B. Methods:Eightyfive patients were randomised into two groups: fourtythree patients as the treatment group treated with conventional medicine combined with bicyclol 25 mg, po, tid, and fourtytwo patients as the control group treated conventionally. Results:When the treatments were accomplished, the negative rate of HBeAg and HBVDNA in the treatment group were significantly higher than in control group. Side effects had not been found.Conclusion:Bicyclol is safe and effective in treating chronic hepatitis B. It can be recommended for a wider clinical application.
    • 药品质量控制
  • 药品质量控制
    Determination of Emodin in Zibushengfa Tablets by RPHPLC
    ZHENG Guoping
    2004, 23(9): 677-0678.
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    To establish a RPHPLC method for determination of emodin in zibushengfa tablets. Method:The column was DiamonsilTM C18, mobile phase methanol0.1% phosphoric acid solution(85∶15), and the detective wavelength 254 nm. Results:Emodin at the concentrations of 1.024－20.480 μg·mL1 showed good linearity, the linear regression equation is A＝72.35C－0.488 9, r＝0.999 9, the average recovery was 99.2% with RSD＝0.67%(n＝5).Conclusion:The method is simple, accurate and repeatable, and can be used in the drug's quality control.
    • 用药指南
  • 用药指南
    Effect of Activated Carbon on Adsorbing Epirubicin in Isolated Hepatic Perfusion
    XIANG Li;LI Dun
    2004, 23(9): 690-0692.
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    Study on the dosage of activated carbon as the absorbent of epirubicin (EPI) in isolated hepatic chemoperfusion.Method:The plasma epirubicin was perfused in the activated carbon columns with different combination. The plasma epirubicin was determined by column switching HPLC. Results:The absorption ratio of epirubicin by A group (150 g×1), B group (150 g×2), C group (150 g×3), D group (150 g×4), E group (150 g×5), and F group (150 g×6) activated carbon columns respectively were (25.60±4.72)%，(38.47±4.02)%，(50.13±2.68)%，(70.25±2.17)%，(72.02±2.21)%，(73.90±4.02)%. There was a significant difference between any two groups of A, B, C, D by q test (P＜0.01). And there was no significant difference between any two groups of D, E, and F(P＞0.05).Conclusion:The suitable dosage of activated carbon is group D which provides a theoretical dose in the therapy of liver cancer by isolated hepatic perfusion.
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