中国科技论文统计源期刊 中文核心期刊  
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊  
日本科学技术振兴机构数据库(JST)
第七届湖北十大名刊提名奖  

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    药物研究
  • 药物研究
    WU Xiang-gen;LI Gao;ZHU Jian-fen;WU Shao-hui
    2004, 23(5): 283-287.
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    Objective:To study the influence of intestine Pglycoprotein drug pumping in rats on norfloxacin absorption.Method:Drug pumping effect of intestine Pglycoprotein in rats on norfloxacin absorption was studied by SDSPAGE and everted sac absorption method in vitro.Results:In SDSPAGE experiment, norfloxacin, verapamil, and propafenone as xenobiotics induced Pglycoprotein expression. Pglycoprotein expressions in experimental groups, especially in group B (norfloxacin), group E (norfloxacin with verapamil), and group F (norfloxacin with propafenone), were significantly increased than in the control group (P<0.05). In everted sac experiment, coadministration of verapamil and propafenone as reverser could significantly increase norfloxacin concentration in the serous side (P<0.05). Conclusion:Intestine Pglycoprotein in rats can decrease norfloxacin absorption by drugefflux pump, and coadministration of reversers can improve intestinal absorption of norfloxacin in vitro. Pglycoprotein expression can be raised by long term administration of norfloxacin, verapamil or propafenone. Intestinal absorption of norfloxacin is related with intestine Pglycoprotein.
  • 药物研究
    DENG Dong -qing;LI Yue-chun;ZHANG Chang-gong;WANG Xiao-gang
    2004, 23(5): 287-289.
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    Objective:To study the condition influenced on the growth of callus of compothecine acuminata decaisne and the production of camptothecin. Method:Based on the various culture medium used in inducing and sub-culture of camptotheca callus, cells were cultivated in suspension, the embryoid was differentiated and thin-layer chromatogram was applied to detect the camptothecin. Results:The most suitable culture medium was B5, and the additional growth regulators were 1.0 mg•L-1NAA and KT 0.1 mg•L-1 Conclusion:There was correlation between the embryoid differentiated by tissue cuture and the biosynthesis of camptothecin.

  • 药物研究
    HU Jian;ZHANG Le-zhi;TANG Yuan;ZHANG Hai-gang;LI Xiao-hui
    2004, 23(5): 290-293.
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    Objective:To determine the effects of panax notoginseng saponins (PNS) on expression of Giα-mRNAs in myocardium and lung tissue of severely scalded rats.Methods:Rats of 30% TBSA Ⅲ degree scald model were used,and varying doses of PNS were fed to the rats 20 min before scald. The change of Gi2α-mRNA,Gi3α-mRNA expression were determined by semi-quantitative RT-PCR method in both tissues 3 h after scalds.Results:After 30% TBSA Ⅲ degree scald model established for 3 h, their Gi2α-mRNA increased by 178.0% (P<0.05) in myocardium and by 263.0% (P<0.01) in lung tissue,and Gi3α-mRNA increased by 236.0% (P<0.01) in myocardium and 222.0% (P<0.05) in lung tissue. Gi2α-mRNA content reduced 46.0% (P<0.01) in myocardium 3 h post scald due to 200 mg•kg-1PNS dose vs the control group; and 35.8%,44.4% and 60.6% (P<0.05 or P<0.01) due to PNS dose of 50, 100 and 200 mg•kg-1in lung tissue. Also Gi3α-mRNA reduced in myocardium 33.9%, 30.1% and 42.9% as well as in lung tissue 34.5%, 54.7% and 55.6%(P<0.05 or P<0.01) due to the three doses respectively. Conclusion:PNS can inhibit the expressions of Gi2α-mRNAs and Gi3α-mRNAs in myocardium and lung tissue of severely scalded rats.
  • 药物研究
    YAN Ju-jiao;JIN Jing;WAN Bo;ZENG Fan-bo;LIU Ling
    2004, 23(5): 294-296.
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    Objective: To study the effect of fubaodangguijiao(FBDJ) on ovaries and uterus of anovulation mice induced by testosterone. Method: The mice model of anovulation was induced by injecting testosterone. After administered FBDJ for two weeks, the mice ovaries and uterus were taken out and observed. Results: In the model of anovulation mice, the weight of ovaries and uterus decreased signifcantly. But the weight in FBDJ group increased in certain way. In the FBDJ group the number of atresic follicles and cystoid follicles decreased; normal follicle and corpus lutein increased; the normal follicle area was enlarged; the uterus glands and endometrium grew by morphology check. The action decreased while the dose increased.  Conclusion:Suitable FBDJ dose can alleviate the level of pathological changes of ovaries and uterus induced by testosterone in mice

  • 药物研究
    GAO Li-yuan;SHI Jin-ping;ZANG Zhi-he;XIN Zhi-wei
    2004, 23(5): 296-299.
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    Objective: To study the effects of wusan granule (WSG) on pulmonary carcinoma and immune functions in tumor-bearing mice.Methods: The inhibitory effeccts of WSG on Lewis lung carcinoma in vivo and on SPC-A1、A2, SMMC-7721 in vitro were observed. Index of immunologic organs-thymus gland and spleen, and formation of IL-2 in Lewis lung carcinomabearing mice treated with WSG were experimented.Results: Both in vivo and in vitro WSG had definite antitumor effects on several types of tumor cell strains. Index of immunologic organs-thymus gland and spleen, and formation of IL-2 in tumor bearing mice were increased significantly.Conclusion: WSG can inhibit proliferation of lung carcinoma, by improving immune functions in mices bearing Lewis lung carcinoma.
  • 药物研究
    LI Jun-hua;HE Xiao-fei;XU Xi-ming;YU Jie-ping
    2004, 23(5): 300-302.
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    Objective:To study the protective effects of glucoside tripterygium total on inflammatory injury in ulcerative colitis rats. Methods: Rat colitis model was induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS). Forty rats were randomised into 4 groups: normal group(untreated), model group, control group and treatment group. The rats in control group were given 2 mL sodium chloride solution by stomach, and the treatment group 40 mg•kg-1 dissolved in 2 mL sodium chloride solution. The iNOS protein expression in colon tissue was examined by immunohistochemistry. The NO and myeloperoxidase (MPO) levels of the mucosa were detected, the macroscopical and histological changes of the colon were checked. Results:In the model group the expression of iNOS, the levels of NO and MPO was higher than that of the normal group and the control group(P<0.01). In the treatment group, the expression of iNOS, the levels of NO and MPO were lower than that in model group(P<0.01); also the macroscopical and histological changes were better than that in model group(P<0.01).Conclusion:Glucoside tripterygium total have protective effects on ulcerative colitis in rats by inhibiting the production of NO and iNOS.

  • 儿科用药专栏
  • 儿科用药专栏
    YU Zhendong;WU Bo;YANG Hong;LIU Weimin;ZHANG Shuangchuan
    2004, 23(5): 304-306.
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    Objective: To find the producing effects on nitric oxide (NO) and interleukin-6 (IL-6) in patients with Kawasaki disease (KD) by intravenous immunoglobulin (IVIG) treatment. Methods: Blood and urine samples were collected from 38 patients with KD before IVIG treatment and 3 days later after the treatment. There were 30 age-matched healthy controls in the study. Serum and urinary NO, IL-6 were measured by ELISA.Results: Patients with KD had higher levels of NO and IL-6 than the healthy controls. Serum NO, IL-6, and urinary IL-6 levels significantly decreased after IVIG treatment. The urinary NO levels had no significant change after the treatment.Conclusion:IVIG may inhibit the producing of NO, IL-6 in patients with KD which mediate inflammation responses.
  • 儿科用药专栏
    CHEN Jinshan;DU Qingyun;HUANG Huili
    2004, 23(5): 307-308.
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    Objective: To analyze the results of carbamazepine serum monitoring in epilepsy children and explore its rational clinical therapy.Method: Serum concentration of carbamazepine was determined by HPLC. Then analyze results. Results: The ratio in the range of effective concentration (4-12 μg•mL-1) were 59.22%, the ratio below 4 μg•mL-1 40.29%, and the ratio above 12 μg•mL-1 0.49%. Conlusion: A great individual variance exists in the serum concentrations of carbamazepine among the epilepsy children, which suggests that an individual drug-administration project is needed in clinical practice to ensure drug effect and therapy safety supported by serum drug monitoring.
  • 药物与临床
  • 药物与临床
    LEI Yingquan;FU Zhongming;FONG Guojun;REN Yusheng;PENG Shunzhou;WANG Dongping
    2004, 23(5): 316-317.
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    Objective:To study the effect of rongshuanjiaonang on fibrinolysis coagulation system in high altitude polycythemia (HAPC) patients. Methods:Thirtytwo HAPC patients as the treatment group took two capsules of rongshuanjiaonang twice daily for 1 mo. And tissuetype plasminogen activator (t-PA), plasminogen activator inhibior-1 (PAI-1), fibrinongen (Fbg) in the plasma were checked before and after the study while thirtyfour health immigrants took nothing as the control. Results:The values of t-PA, PAI1, and Fbg changed from (0.64±0.17) U•mL-1, (1.48±0.24) AU•mL-1, (4.55±1.21) g•L-1 to (1.53±0.23) U•mL-1, (0.66±0.10) AU•mL-1, and (1.53±0.23) U•mL-1. By comparison, t-PA, PAI-1, and Fbg were significantly changed in the HAPC patients (P<0.05). Conclusion:Rongshuanjiaonang can improve function of fibrinolysis coagulation system in HAPC patients.
  • 用药指南
  • 用药指南
    WANG Jianping;JIN Dayuan;TIAN Xiaoning
    2004, 23(5): 354-356.
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    Objective: Investigate and analyze the using situation and the trend of antihistamine drugs in 6 cities. Methods: Survey the drugs in 146 hospitals of 6 cities during 20002002, especially the sum of money for drugs. Results: The sum of money of antihistamine agents is 4.171 43 mil. yuan, 4.382 91 mil. yuan, 3.908 67 mil. yuan in 2000, 2001, and 2002 respectively.Conclusion: Cetirizine and lortadine were most frequently used in the treatment of allergic reactions. Much attention must be paid to the their cardiotoxicity even the incidence is relatively low.
  • 用药指南
    2004, 23(5): 356-357.
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  • 用药指南
    LU Kesheng;ZHOU Guoying
    2004, 23(5): 358-360.
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    Objective: To investigate the using of antihypertensives in Fenghua hospital.Method: The outpatient prescriptions with antihypertensives from January to May in 2003 in the hospital were statistically analyzed.Results: Out of the 12 677 of prescriptions, 90.0% had one or two antihypertensive drugs. Zhenjujiangya tablets, Captopril, Nifedipine were more frequently used than others. Out of the 12 677 of prescriptions, 1 090 prescriptions (8.6%) were irrational. Conclusion: Most of hypertensive prescriptions were suitable to the basic control of bloodpressure and personalized treatments except some irrational prescriptions. Therefore rational investigation in antihypertensives prescriptions are essential in order to reduce the relative adverse reaction.
  • 用药指南
    2004, 23(5): 362-363.
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