中国科技论文统计源期刊　中文核心期刊  
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    药物研究
  • 药物研究
    ColonSpecific Delivery Release of PLDextran(20 000) Prodrug in the Rat GI Tract
    ZHOU Jin;MEI Qibin;ZHOU Siyuan;LI Pin;HE Jianrong
    2003, 22(5): 297-299.
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    Objective:To observe colonspecific delivery release of PLdextran(20 000) prodrug in the rat GI tract for seeking new drug to treat inflammatory bowel diseases.Method:PL prodrug and PL were administrated respectively to rats by oral gavage at the dose of 30 μmol•kg1. The distribution of PL in the contents and mucosa of different parts of the rat GI tract between different interval and the fluctuation of PL concentration in plasma were determimed by HPLC. Drug delivery index (DDI) was calculated.Results:PL was mainly released in cecum and colon contents or mucosa after gastric administration of PL prodrug, while PL was mainly distributed in stomach, PSI and DSI contents or mucosa after administration of free PL at the same dosage. The DDI of prodrug was 6.464 in the cecal mucos of the rat. Conclusion:It seems that the PLdextran(20 000) prodrug has a potential for the treatment of colitis
  • 药物研究
    Growth Inhibition of C6 Glioma in Rat by Vascular Endothelial Growth Factor Antisense Oligodeoxy Nucleotides
    LI Zhiqiang;YUAN Xianhou;JIANG Pucha
    2003, 22(5): 299-301.
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    Objective:To explore the probability of vascular endothelial growth factor(VEGF) antisense oligodeoxynucleotides(AODN) as a new auxiliary therapeutic strategy to glioma. Method:VEGF protein expression was detected by SP immunohistochemical technique. Tumor cells apoptosis and the structure of vascular were detected by TUNEL method and electron microscope respectively. Results:Compared with control, VEGF protein expression was inhibited by AODN. The inhibitory effects increased with the increasing concentration. VEGF positive rate was 82.10% in control group, while in 1.0, 2.5, 5.0, 10.0 μmol·L1 AODN groups, they were 73.10%, 70.00%, 57.85% ,53.20% respectively. In vivo, AODN therapy reduced the size of the subcutaneous tumor, increased the apoptotic tumor cells and enlarge the necrotic area within the tumor. Electron microscope also showed that vessel diameter became smaller and basic membrane became thick.Conclusion:It is hopeful that VEGFAODN therapy which can inhibit tumor growth and angiogenesis may have clinical utility as a new therapeutical method for glioma
  • 药物研究
    Experimental Study of Effects of in Feiyanqing Stopping Cough, Removing Sputum and Calming Asthma
    XIANG Xixiong;LIU Changyu;YUE Qin;HUA Neng;XIA Xinhong;FU Zhen;LI Hangsen;YANG Lin
    2003, 22(5): 301-302.
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    Objective:To study the pharmacodynamics of feiyanqing in stopping cough, removing sputum and calming asthma. Method:Feiyanqing was dispensed in different doses given to the models of family mice. Then the effects of stopping cough, removing sputum and calming asthma were observed. Results:The feiyanqing groups with high, moderate and low doses could all markedly prolong cough latent period and reduce cough times in the experiment of stopping cough. Comparing with the control group, there was great significant difference (P＜0.01); The feiyanqing group with high dose could remove sputum evidently in the experiment of removing sputum, comparing with the control group, there was significant difference(P＜0.05); the feiyanqing groups with high, moderate and low doses could inhibit asthma reaction obviously and prolong asthma latent period in the experiment of claming asthma. Comparing with the control group, there was great significant difference(P＜0.01).Conclusion:Feiyanqing has the function of stopping cough, removing sputum, calming asthmas in the experimental mice
    • 儿科用药专栏
  • 儿科用药专栏
    Studies on Mechanism and Effects of Scopolamine on Neonates with Hypoxicischemic Encephalopathy
    ZHANG Wei;LI Yuanxiu;LI Xianqing;ZHAI Min;LIAO Tingyan
    2003, 22(5): 303-306.
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    Objective:To study the mechanism of HIE on neonates and the change of cerebral hemodynamics, and to explore the mechanism and effects of scopolamine in treating HIE.Method:Ultrasonography and doppler were used to determine the indices of hemodynamics of ACA、PCA and MCA by imaging 51 neonates with HIE and 48 cases of nonHIE infants at the ages of 3rd day and 7th day after birth; to determine the parameters of hemodynamics by imaging 51 neonates with HIE who were given scopolamine and 60 neonates with HIE who were not. Results:At the age of 3 days, the cerebral blood flowing speed of HIE group was generally lower than that of nonHIE group, and the most obvious reduction occurred in ACA on both sides(P＜0.05) and PCA on the left(P＜0.01). At the age of 7 days, the flowing speed of HIE group recovered, only the speed of left PCA was obviously lower that of than nonHIE group. And the parameters of ACA, MCA, PCA in hemodynamics were improved more obviously than those of the nonscopolamine group. According to the results of NBNA and IQ in scopolamine group, HIE recovered more quickly and earlier than the nonscopolamnie group. Conclusion:The flowing speeds of HIE infants’ ACA, MCA, PCA are generally lowered, which is inconsistent with the injury parts of HIE. Therefore, the change of cerebral hemodynamics of HIEinfants is one of the pathological mechanisms in HIE. Scopolamine can obviously improve the cerebral hemodynamics of HIE infants, which means it can prevent cerebral ischemia injury and cerebral hemodynamics from viciously circling. Scopolamine favours the recovery of cerebral functions at the key age period
  • 儿科用药专栏
    Clinical Study of Bronchoalveolar Lavage with Azithromycin in Treating Pediatric Pneumonia
    WANG Zhinan;WEI Youhua;XU Zhongqiang
    2003, 22(5): 306-307.
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    Objective:To evaluate the effect of Bronchoalveolar lavage (BAL) with azithromycin(AZM) to treat pediatric pneumonia. Methods:A retrospective study of 77 cases in onemonth history were reviewed. They were randomly divided into two groups in which one group of 45 cases were given BAL with 0.9% natrium chloride (N.S) and the other group of 32 cases were given BAL with AZM. No case had fungle or mycobacterium tuberculosis infection. Results:The cure rate of the control group was 80.0% and the AZM group 81.2%; the total effective rate was 100.0% in both groups. There was no significant statistical difference in two groups. But the average inward days of the control group were 11 and in AZM group was 8 days, There were significant statistic difference of average inward day in two groups.Conclusion:The therapeutic procedure of pediatric pneumonia can be shortened by BAL with AZM, which can be applied in clinical practice in an active sence
    • 药物与临床
  • 药物与临床
    Effect of Anisodamine on Uteroplacental Circulation in Pregnancyinduced Hypertension
    WANG Hongyan;DUAN Yunyou;YUAN Lijun
    2003, 22(5): 312-313.
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    Objective:To observe the short-term effect of anisodamine on blood flow of uterine and umbilical arteries in 14 pregnant women with pregnancyinduced hypertension (PIH) by means of colour doppler. Method:14 cases of pregcancyinduced hypertension were given anisodamine 10－20 mg added into 500 mL 5% GS by intravenous drip. We observed the blood pressure, weight and proteinuria before and after therapy and measured blood flow of uterine and umbilical arteries by means of doppler ultrasound technique. Results:Anisodamine could decrease the S/D ratio, resistant index(RI), and pulsative index(PI) of blood velocity in these arteries with statistically significant difference(P＜0.01).Conclusion: The resistance in uteroplacental circulation was decreased and its perfusion improved, which favors the maternal and fetal growth and development
  • 药物与临床
    Influence of Flunarizine Hydrochloride on Plasma Endothelin in Patients with Subarachnoid Hemorrhage
    JIANG Baoying;XIANG Jianping;XU Houchi
    2003, 22(5): 313-314.
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    Objective:To study the influence of flunarizine hydrochloride on the content of the plasma endothelin(ET) in patients with subarachnoid hemorrhage(SAH) and discuss the mechanism of flunarizine hydrochloride in the prevention and treatment of cerebral vasospasm (CVS) after SAH.Method:44 cases of SAH were divided into flunarizine hydrchloride group (20 cases) and SAH control group (24 cases) randomly. Radioimmunoassay was used to measure the content of plasma ET at different times. Results:The content of plasma ET in flunarizine hydrochloride group was compared with those in SAH control group and nomal control group (P＜0.01, P＜0.05) at different times. After treatment with flunarizine hydrchloride, the content of plasma ET in flunarizine hydrochloride group was significantly lower than that in SAH control group (P＜0.01, P＜0.05), and it was also significantly lower than that in flunarizine hydrochloride group before treatment (P＜0.01). Conclusion:Flunarizine hydrochloride can prevent and treat the CVS after SAH, and ensure the blood supply of cerebral tissues by decreasing the content of plasma ET.
  • 药物与临床
    Analysis of Therapeutics of Organic Mental Disorder by Olanzapine
    SUN Qingqi;CHEN Min;TONG Rong;ZHANG Yanfei;ZHANG Tongyan
    2003, 22(5): 315-316.
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    Objective:To comprehend the effect and safety of olanzapine in treating organic mental disorder.Method:Thirtysix patients of organic mental disorder were treated by olanzapine for a week. excitation factor(BPRS)、clinical global impression(CGISI), duration of sleeping, ECG、liver/renal function before and after administration of the drug were analyzed by selfTtest.Results:Except that 1 case with encephalitis was inefficient, BPRS and CGISI scores of 1 case were decreased by more than 75%, 15 cases were between 50% and 74%, 19 cases were between 25% to 49%, the efficiency was 47.2%,total efficiency was 97.2%.There were significant differences in CGISI, duration of sleeping and medical care scores before and after therapy(P＜0.01), BPRS scores were decreased by more than 40%, but there were no significant differences in TESS, ECG and liver/renal function(P＞0.05).Conclusion:Olanzapine is effective and safe in treating organic mental disorder
  • 药物与临床
    Intravesical Perfusion of Pirarubicin in the Prophylaxis of Recurrence after Resection of Bladder Cancer (56 Cases)
    WANG Anfang;DONG Dexin;WANG Weifu
    2003, 22(5): 317-318.
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    Objective:To evaluate the effect and sideeffect of intravesical perfusion of pirarubicin (THP) after resection of bladder cancer. Method:Compared with 30 cases with intravesical perfusion of mitomycin (MMC), 56 cases after resection of bladder cancer were given intravesical perfusion of THP so as to observe the effect and sideeffect of THP. THP group was divided into two subgroups, one subgroup with THP retained in the bladder for 30 minutes and the other one for 60 minutes, to observe the effect of retained time and the effect and sideeffect of THP.Results:The recurrence rate of bladder cancer in THP group was 16.1% and that in MMC group was 33.3%, hence THP group was significantly lower(P＜0.01) in recurrence rate than MMC group; but there was no significant difference in sideeffects in the two groups(P＜0.05). There was no significant difference in effect and sideeffects in the two subTHP groups(P＞0.05).Conclusion:The effect of THP to prevent postoperative recurrence of bladder cancer is better than that of MMC, but the sideeffects of both are the same. There is no obvious relation of the effect and sideeffect of THP to retained time in bladder.
    • 药品质量控制
  • 药品质量控制
    Research and Quality Control of the Podophyllotoxin Gelatum
    CAO Jian
    2003, 22(5): 327-328.
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    Objective:To investigate the technological process and the method of quality control of the podophyllotoxin gelatum. Method:The first order derivative spectrophotometry was used to determine the content of podophyllotoxin.Results:During 42.12－112.32 μg•mL1, the podophyllotoxin’s concentration in the prescription is in direct proportion to the amplitude of the first order derivative spectrophotometry at 249 nm. C＝548.811 4D－2.449 1,r＝0.999 9.Conclusion:The technological process of podophyllotoxin gelatum is simple, the method of quality control is easy
    • 药物与临床
  • 药物与临床
    Determination of Paeoniflorin Content in Qingguangkang Tablets
    LIAO Jianping;REN Weiqiong
    2003, 22(5): 328-330.
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    Objective:To determine the paeoniflorin content in qingguangkang tablets so as to establish a quality standard for qingguangkang tablets. Method:The content of paeoniflorin in the product was determined with HPLC method.Results:The linear range of paeoniflorin concentration was 0.104－0.520 μg•mL1 and correlation coefficient was 0.999 3. The average recovery of sample was 98.00% with a RSD of 1.18%(n＝6).Conclusion:The method is suitable for the quality control of qingguangkang tablets.
    • 药品质量控制
  • 药品质量控制
    Content Determination of Baicaline in Kexinkang Tablets with ReversedPhase High Perfarmance Liquid Chromatography
    LI Jinxiu;GAO Changqing;YANG Lihua;JIA Shanxue
    2003, 22(5): 330-331.
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    Objective:To dominate the quality of kexinkang tablets by determining the content of baicaline in kexinkang tablets with reversedphase HPLC. Method:Baicaline was separated on spherisorb C18 column by using methanolacetic acidwater(40∶1∶60)as a mobile phase and UV detection wavelength at 274 nm.Results:The resolution was 5.0; The number of theoretical plates calculated for Paeoniflorin peak was 25 870; The average recovery of the added index was 98.8%(n＝5). RSD got in the times of determination was 0.92%. There was a good linear relationship between the concentration of baicaline and absorption area value in the range of 0.25－2.50 μg.Conclusion:The methed was highly reproducible and accurate.
    • 用药指南
  • 用药指南
    Investigation and Analysis of the Utility of Antimicrobials for Inpatients in Daping Hospital
    FU Ruoqiu;MENG Desheng;CHEN Liang
    2003, 22(5): 340-341.
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    Objective:To investigate the situation of the use of antimicrobials for inpatients in daping hospital. Method:The antimicrobials used for inpatients in daping hospital in August 2001 were classified, analysed and compared in respect to the kinds, sum of money, days of consumption, etc. Results:The sum of money of antimicrobials used for inpatients in daping hospital accounted for 16.91% of that of all drugs in August 2001. Cephalosporin was the biggest consumption among all antimicrobials used in this hospital. The daily expenses of injection antimicrobials and oral antimicrobials were 168.01 yuan and 11.61 yuan respectively. The antimicrobials whose DUI was greater than 1.2 reached 50%. Conclusion:In daping hospital, the adminisfration dosages and expenses of antimicrobials are both on the high side.
  • 用药指南
    Survey and Analysis of the Use of Antimicrobials in 295 Patients in Departments of Surgery
    MA Nifei;CHEN Longying;OU Renhao
    2003, 22(5): 342-343.
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    Objective:To find out the situation of antimicrobial application in patients of departments of surgery and to put forward corresponding suggestions. Method:The antimicrobial use in patients of departments of surgery was analysed in respect to the kinds, frequency, combined administration of antimicrobials and drugresistance of isolated pathogenic bacteria. Results:The first 10 most frequeortly used antimicrobials were amikacin, ofloxacin, metronidazole, gentamicin, penicillin, cefotaxime, ciprofloxacin, cetazolin, norfloxacin and tinidazole. Irrationality of druguse was mainly revealed in improper selection of drugs and improper time of administration.Conclusion:Rational druguse will help promote the rising of integral medical level and decrease the emergence of drugresistant bacteria
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