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    药物研究
  • 药物研究
    Effects of Three KidneyTonifying Recipes on Neurotransmitters in Inferior Colliculus of 24Month Aging Rats
    WANG Jing;SHI Jianrong;JIN Guoqin;QI Xiaoyan;GUO Ruixin
    2003, 22(3): 142-144.
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    Objective：To compare the effects of three kidneytonifying recipes on the neurotransmitter system in inferior colliculus (IC) of aging rats. Method：24month aging SD rats were divided randomly into four groups: aging, zuogui bolus, yougui bolus, and experienced recipe groups, another 20 young rats were taken as control. Examine the levels of amino acid neurotransmitters by HPLC, the specific binding with 3HGABA by GABA receptors and 3HGlu by NMDA receptors, the gene expression of GABAB R1a, R1b and NMDA R1A, R2A mRNA by RTPCR. Results：Compared with the young group; the aging group showed an unbalance between the excitatory and inhibitory system in IC, resulting in a relatively lower inhibitory effect mediated by GABA. It may be contributed to the increase of the incidence of tinnitus with aging. The experienced recipe group showed a strong positive effect on upregulation of inhibition and downregulation of excitationd levels mediated by the amino acid neurotransmitters in IC, while the zuogui bolus and yougui bolus group increased both excitatory and inhibitory amino acid neurotransmitters.Conclusion：There is a hint that in treating tinnitus of aging it may be better to combine kidneytonifying herbs with the herbs of promoting blood circulation, removing blood stasis, etc
  • 药物研究
    The Inhibitory Effect of Alcohol on Seizure Activity in Amygdaloid Kindled Rats
    YANG Bo;FANG Xuan;SU Yanyou;WANG Lei;SHAO Boqin;YUE Wang
    2003, 22(3): 145-146.
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    Objective：To investigate and observe the inhibitory effect of alcohol on seizure activity in kindled rats. Method：The effect and mechanism of alcohol on kindling and its development were examined by the establishment of amygdala kindling model and combination with other drugs. Results：Alcohol, at doses of 0.5 to 1.5 g•kg1, ip, increased the focal threshold after discharge, reduced the Racine’s degrees, seizure severity and the percentage of generalized seizure. Compared with the control group, the alcohol groups inhibited the development of kindling (P＜0.01) and seizure activity in kindled rats(P＜0.05). The combination of alcohol with phenobarbital or diazepam, all at ineffective doses on kindling, showed no significant effects on ADD and Racine’s degree. Conclusion：Alcohol can inhibit the progress of kindling and seizure activity in amygdaloid kindled rats,but at ineffective doses on kindling, has no synergism with phenobarbital or diazepam.
  • 药物研究
    Effect of Cefoperazone on Pharmacokinetics of Theophylline
    LI Mengquan;GUAN Lixin;GAO Xueling
    2003, 22(3): 147-150.
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    Objective：Probe the effect of cefoperazone on the pharmakinetics of theophylline so as to provide the data for using theophylline rationally in clinic.Methods：Six rabbits were given theophylline by venous injection at the dose of 10 mg•kg1. Blood samples taken from ear venous at different times were detected by HPLC. Draw the drug time curve of theophylline. After a week of taking cefoperazone at the dose of 40 mg•kg1 i.m per day, draw the drugtime curve again. to calculate the pharmacokinetics parameters. Results：Cefoperazone changed the parameter of theophylline as follows: AUC, T1/2 and Vd decreased; Ke increased while CL had no change. Conclusion：Cefoperazone has effect on the pharmacokinetics parameters of theophylline. The dose of theophylline should be modulated when combined with cefoperazone in clinical treatment
    • 心血管系统用药专栏
  • 心血管系统用药专栏
    A Clinical Study on the Effect of Salvianotoginseng Capsule on Cerebral Vascular Hemodynamics in Hypertension
    XIAO Qiang;XU Dansheng;XIAO Xiangjun;HU Jiaquan;ZHANG Zhenhai;WANG Ruijiang
    2003, 22(3): 151-153.
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    Objective：To observe the clinical therapeutic effect and change of the cerebral vascular hymodynamics analyzing(CVA) index of hypertension with salvianotoginseng capsule. Methods：62 cases (observation group) took salvianotoginseng capsule 1.8 g each time, twice daily, while another 50 cases as control group took captopril, 25 mg each time 3 times daily, all for 90 days. Blood pressure and the index of CVA such as Qmean, Vmax, Vmean, Vmin, Zcv, Wv, DI, Rv, SP, DP during the period of treatment were recorded. Results：It was observed that the systolic pressure (SBP) of the observation group was lowered down from (157.9±24.2) mmHg to (140.9±13.2) mmHg, diastolic pressure (DBP) from (94.7±9.8) mmHg to (87.6±7.8) mmHg with a similar effect to the control group (96.8%/96.0%, P＞0.05). More important, it was found that CVA index of the observation group had a significant change when compared to the control group (χ2＝54.8, P＜0.01). The followups showed that the morbidity of stroke and frequency of blood pressure unstability were lower in the observation group than those in the control group (0/4.44%; 0/6.52%, χ2＝4.8, P＜0.05). Conclusion：Salvianotoginseng has a slow but lasting and reliable effect on lowering the hypertension. It also improves the index of CVA and can prevent strokes from occurring.
  • 心血管系统用药专栏
    Antiarrhythmic Effect of Water Extraction Liquid of Clivia
    HUANG Caiyun;XIE Shirong;HUANG Shengying
    2003, 22(3): 154-156.
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    Objective：To observe the antiarrhythmic effects of water extraction liquid of clivia(WELC). Method：Chemical druginduced arrhythmic models and coronary ligation induced arrhythmic models were used to investigate antiarrhythmic effects of WELC. Results：WELC 6 g•kg1 and 12 g•kg1 could inhibit markedly the ventricular arrhythmias induced by aconitine 20 μg•kg1 or BaCl2 2 mg•kg1 or coronary ligation in rats. WELC also obviously reduced the incidence of atrium fibrillation produced by CaCl2Ach (CaCl2 0.6%＋Ach 0.002 5%) 10 mL•kg1 in mice. These actions were similar to quinidine. The ECG of rats demonstrated that after iv administration of WELC 6 g•kg1, the heart rate was slowed down, and the PR and QT intervals were prolonged. Conclusion：WELC has obvious antiarrhythmic effects in rats.
  • 心血管系统用药专栏
    Effect of Valsartan on Heart Function and QT Dispersion in Patients with Heart Failure
    LIU Xiangru;TAN Xiaojun;ZHANG Xiaohong;CHEN Xiaoliang;WANG Zhonghua
    2003, 22(3): 156-158.
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    Objective：To evaluate the effect of valsartan on QT dispersion and heart function in patients with dilated cardiomyopathy(DCM). Methods：Among the 84 DCM patients, 44 underwent valsartan treatment and 40 underwent captopril treatment. The QTd and heart function were observed and compared after 2 weeks. Results：The treatment group was superior to the control group in therapeutic effect, changes of heart function and changes of QTd. Conclusion：valsartan in treating DCM is batter than captopril in improving function of the left ventricle and reducing the occurrence of arrhythmias.
  • 心血管系统用药专栏
    Antihypertensive Efficacy of Bisoprolol by Dynamic Blood Pressure Monitoring
    HU Wanbao;HU Yong;WANG Shehong
    2003, 22(3): 158-159.
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    Objective：To investigate the antihypertensive efficacy of Bisoprolol by dynamic blood pressure monitoring.Methods：Twentyfive patients with mild to moderate essential hypertension were given Bisoprolol 5 mg once daily for 4 weeks. Results：The blood pressures were significantly lower after treatment than before. The total effective rate was 92.0%. Mild change of slowing down in heart rate was found. The trough/peak ratios of systolic and diastolic blood pressure were 64.0% and 71.0% respectively.Conclusion：Bisoprolol is safe and effective in the treatment of mild to moderate hypertension, especially in patients with myocardial ischemia and bradyarrhythmias
  • 心血管系统用药专栏
    Relativity of Valproic Acid Concentration in the Blood and its Antiepilepsy Effect
    TANG Rongfu;YU Xing
    2003, 22(3): 165-166.
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    Objective：To understand relativity of the valproic acid concentration in the blood and its antiepilepsy effect.Method：The valproic acid concentration in the blood was measured by fluorescence polarization immunoassay analyzer. Results：Effective valproic acid concentration in the blood was 50～100 μg•mL1. The antiepilepsy effect was better within the concentration range. The antiepilepsy effect was less below the rang and adverse reactions occurred over the range. Conclusion：Good relativity exists between the valproic acid concentration in the blood and its therapeutic effect.
    • 药物与临床
  • 药物与临床
    Effect of Fluconzole in Treating Urinary Tract Fungal Infections
    HAO Junwen;LI Xiangtie;YANG Dean;LIU Shaoge;LIU Yangdong;ZHANG Aimin
    2003, 22(3): 166-167.
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    To observe the effect of fluconzole in treating urinary tract fungal infections. Method：15 patients with urinary tract fungal infections were given fluconzole 200 mg, intravenous drip, bid, from 7 to 10 days. When their clinical signs were alleviated, the dosage of fluconzole was reduced to 100 mg, po, bid, from 15 to 20 days for supporting treatment.Results：The clinical efficacy rate was 93.3%, the fungus clearance rate being 86.7%. The adverse reaction of fluconzole was very little. Conclusion：Fluconzole is a kind of effective drug for treating the urinary tract fungal infections.
  • 药物与临床
    Chemotherapy Combined with Zhenqifuzheng Capsules in the Treatment of Cancer (76 Cases)
    QI Meiqin
    2003, 22(3): 168-169.
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    Objective：To explore the clinical prognosis and marrow inhibition by chemotherapy combined with zhenqifuzheng capsules in the treatment of cancer.Methods：76 patients were randomly divided into 2 groups. The obvervation group (38 cases) were treated with chemotherapy combined with zhenqifuzheng capsules 4 caps, po, tid, for 4 weeks. The control group(38cases) were treated with chemotherapy only. Observing the prognosis and the counting of white blood cells, hemoglobin and blood platelets from the first to fourth week. Results：The remission rate was higher in the observation group(42.2 %) than that in the control group (36.8 %), but no significant difference increased(P＞0.05). There was a higher white blood cell count as compared with the control group, at first week, second week and third to fourth week(P＜0.05), whereas there was no significant difference in the counting of hemoglobin and blood platelets(P＞0.05). Conclusion：No beneficial effect of zhenqifuzheng capsules was evident in terms of remission. However it markedly inhibited the decrease of white blood cells.

    • 药物制剂
  • 药物制剂
    Preparation of Lomefloxacin Hydrochloride Eyedrops
    WANG Jianlin
    2003, 22(3): 182-182.
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    Department of Pharmacy, the Hospital of Fuping County, Shanxi 711700, China) ABSTRACTObjective：Using the sodium hyaluronate as carrires, to improve the concentration and lubricity of the eye drops, increase the effects and decrease the dosage.Methods：The preparation of the eyedrops and its qualities including characters, concentration and stability were studies. Its clinical effects were also observed. Results：Sodium hyaluronate did not change the characters of LFLX or interfere with the concentration. Having been observed for 18 months, it showed a better quality and biointermiscibility, the effective rate of the eyedrops being 96.5%. Conclusion：The method is simple with good stability, and the rapeutic effects.
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