中国科技论文统计源期刊　中文核心期刊  
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊  
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖  

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    药物研究
  • 药物研究
    Determination of Phenobarbital in Serum by Improve Differential Spectrophotometer
    TANG Fen;GU Rong;ZHANG Zhenqi;LIU Bin
    2003, 22(1): 12-15.
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    Objective:To improve differential spectrophotometry for the determination of phenobarbital in serum. Method:Phenobarbital in serum was twice extracted with trichoromethane under acidic conditions. The standard curve of phenobarbital in serum was established according to the absorbance deviations of phenobarbital in base and acidic media, and the phenobarbital in serum was determined by differential spectrophotometry. Results:The linear range of phenobarbital in serum was 2～80 μg•mL1, the average recovery was (100.66±0.36)% with RSD (2.17±0.08)% and (2.59＋0.24)% for intraday and interday respectively. The phenobarbital in serum was stable in 25 min under base conditions of pH＝10.00Conclusion:The method now used is quick, simple, of high sensitivity and of good repeat. It is cheap and easy to obtain the instrument and reagent and suitable for clinical drug monitoring in small and mediumsized hospitals.
  • 药物研究
    Determination of Bioavailability of Domestic and Imported Cetirizine Hydrochloride
    SUN Li;LIU Xiaoyan;FEI Yanqiu;CAO Huiming;ZHU Deqiu;WANG Pingquan
    2003, 22(1): 15-17.
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    Objective：To compare the pharmacokinetic parameters and relative bioavailability of domestic and imported cetirizine hydrochloride tablets in 12 healthy volunteers.Method：An open, randomised, twoperiod crossover study with a two week washout interval was conducted in 12 male healthy volunteers. A reversedphase high performance liquid chromatography(RPHPLC) method was used for the determination of cetirizine. Results：The pharmacokinetics parameters after a single oral dose of 10mg domestic and imported tablets were as follows: Cmax were(429.00±108.80) ng·mL1 and (469.82±113.83) ng·mL1, Tmax were (0.90±0.51) h and (0.91±0.40) h, AUC were (3 312.72±682.39) ng·h·mL1 and (3 417.11±517.42) ng·h·mL1, respectively. The relative bioavailability of domestic tablets was (97.21±13.32)%. Analysis of variance revealed that there was no significant difference between the two preparations of cetirizine hydrochloride. Conclusion：The domestic and imported cetirizine hydrochloride tablets were bioequivalent.
  • 药物研究
    Effect of Compound Penetration Enhancers on Permeability of Amlodipine Through Rabbit Skin
    GUO Yankun;HE Xinhua;MEI Wuxuan;ZHOU Yun;BAO Cuiyu
    2003, 22(1): 18-19.
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    Objective：To study the effect of compound penetration enhancers on the in vitro permeability of amlodipine from the suspension through rabbit skin. Method：30% ethyl alcohol is used as solvent and mixed with amlodapine saturated suspension containing different kinds of penetration enhancers. Then its permeability effect through rabbit skin was determined by using the Franz's type diffusion cell. Results：The penetration rates of amlodipine increased by enhancers in the following order : propylene glycol＜oleic acid＜Azone＜Azone ＋propylene glycol＜oleic acid＋propylene glycol. The steady speed of oleic acid and propylene glycol was probably 2.7 times as that without adding enhancers. Conclusion：Compound penetration enhancers had good effect on the in vitro permeability of amlodipine from the suspension through rabbit skin.
    • 论文
  • 论文
    Treatment of Acute Bacterial Infections with Amoxicillin/Sulbactam Sodium
    XIN Jianbao;LUO Changqing;JIN Yang;YAO Lijun;ZHANG Jianchu;FU Ling;DENG Anguo
    2003, 22(1): 26-28.
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    Objective：To study the clinical effect and security of amoxicillin/sulbactam of Chinaproduce in treating acute bacterial infections. Methods：By using the design of randomized singleblind controlled clinical trial, 41 patients were divided into two groups: trail group 21 and control group 20. The trial group was give, amoxillin/sulbactam 4.5－9.0g•d1, The control group was given ampicillin/sulbactam 4.5－12.0 g•d1, The drug injections being divided into 2 to 3 portions given by intravenous drip for both groups. Results：In the trail and the control groups, the recover rates were 71.4% and 75.0% respectively, the effectiveness rates were 95.2% and 95.0%, the positive bacterium rates were 80.9% and 90.0%, the rates of producedenzyme were 76.5% and 66.7%, the rates of bacteriumclearance were 94.1% and 94.4%, and the incidences of adverse reaction were 9.5% and 15.0%. There was no significant difference about these parameters between the two groups (P＞0.05). Conclusion：Amoxicillin/sulbactam sodium for injection has a wide antibacterial spectrum, strong antibacterial activity, obvious curative effect and little adverse reaction.
  • 论文
    Effect of Fluticasone Propionate in the Treatment of 42 Cases of COPD
    JI Dongyuan;YANG Yong;YU Xinqiang;MA Dan
    2003, 22(1): 29-30.
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    Objective：To discuss the indication of drug administration, effect and the correlative history of the moderate to severe stable COPD patients inhaling glucocorticoid in high dose. Method：The 42 of cases of the moderate to severe stable COPD patients, the glucocorticoid inhaled was fluticasone propionate(250－750 μg b.i.d) and the trial period was 12 weeks. Comparison was made among the change of FEV1 and FEV1/FVC before and after administer. Many risk factors such as chronic bronchitis, asthma, smoking, enviroment, profession and family history etc were selected for correlative research. Results：The total rate of efficiency was 39.3%. The 42 cases of the moderate to severe stable COPD patients comprises the 26 cases of chronic bronchitis (61.9%), the 8 cases of asthma (19.0%) and the 8 cases of COPD family history (19.0%). Conclusion：The effect of in haling fluticasone propionate was proved to be related with many risk factors.
  • 论文
    Therapeutic Effects of Inhaled Budesonide in Treating Bronchiolitis (22 Cases)
    YU Ningfen
    2003, 22(1): 31-32.
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    Objective：To evaluate the therapeutic effects of inhaled budesonide nebulising suspension on bronchiolitis in children. Methods：44 infants, 2－18 months of age, needing hospital treatment because of bronchiolitis, were divided randomly into two groups. All received the same general treatment. 22 infants in the control group received general therapy only, 22 infants in the treating group received extra treatment with inhaled budesonide, 500 μg twice per day, administered via a nebulizer. The clinical effects of budesonide were evaluated in both groups. Results：The treated group showed a rapid improvement in respiratory symptoms (such as cough, wheezing) with a cure rate of 90.91%. The cure rate of the control group was 63.64%. There was significant difference between the two groups (P＜0.01). Conclusion：The results of study indicate that inhaled budesonide in nebulized form treating bronchiolitis may remarkably reduce course of treatment and improve curative effect with convenience in use and few sideeffects
  • 论文
    Efficacy of Amoxicillin/Clavulanate Potassium in Treating Lower Respiratory Tract Infection (70 Cases)
    SHI Jun;TANG Xueyi;FENG Keqing;MA Xitao
    2003, 22(1): 33-34.
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    Objective：To study the therapeutical efficacy of amoxicillin/clavulanate potassium chewable tablets (CPA) in treating lower respiratory tract infection by comparing with the efficacy of cefaclor. Methods：A total of 130 patients were randomly divided into two groups: 70 patients in the treatment group received CPA 0.5 g tid; 60 patients as the control group received cefaclor 0.25 g tid, both for 7～14 days. The efficacy and safety of the two groups were evaluated. Results：Therapeutic courses of the treatment group and the control groups lasted (9.5±3.3) days and (9.1±3.3) days respectively. There was no statistically significant difference (P＞0.05). Effective rate of the treatment group was 92.8%, and that of the control group was 80.0%. Bacterial clearance rates of the two groups were 91.4% and 71.6% respectively. No obvious adverse reaction was found during the therapeutical period. Conclusion：Amoxicillin/clavulanate potassium has a good therapeutical effect in treating lower respiratory tract infection with safety. It is worthy of spreading.
  • 论文
    Clinical Efficacy and Safety of Azithromycin Injection in Treating Lower Respiratory Tract Infection of Children (112 Cases)
    YU Ying;LU Zhifang
    2003, 22(1): 35-36.
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    Objective：To evaluate the clinical efficacy and safety of azithromycin injection in treating lower respiratory tract infection of children. Method：A total of 186 patients were included in this study, 112 cases treated with Azithromycin were compared with 74 cases treated with Erythromycin. Drugs were administered by intravenous drip once daily for 5～7 days, at a daily dose of 6～8 mg•kg1•d1 of Azithromycin or 20～25 mg•kg1•d1 of Erythromycin. Results：The overall clinical efficacious rate of Azithromycin was 89.28%. and that of Erythromycin was 72.97%. There was significant difference(P＜0.05).The incidence of adverse drug reactions for Azithromycin was lower than that for Erythromycin. Conclusion：Azithromycin is an effective and safe antibiotic for the treatment of lower airway infection in childern
    • 药物与临床
  • 药物与临床
    Application of Total Parenteral Nutrition in Rescuing the Critical Premature
    HONG Shaoxian;LAI Changhu;ZHUO Zhiqiang
    2003, 22(1): 43-44.
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    Objective：To apply total parenteral nutrition (TPN) in rescuing the critical premature.Method：30 cases of critical premature, 2－7 days after birth, were treated by intravenous perfusion with the mixture nutrition of glucose, 5% compound amino acid injection, 20% lipofundin, watersoluble vitamins and liposoluble vitamins. The mixture was administered by perfusion pump in even speed all day. The course of treatment lasts 5－28 days. Results：30 cases were all discharged from hospital after recovery. 5 of them suffered from hyperbilirubinemia but became normal after reducing the lipofundin dosage. Conclusion：The effects of TPN for the premature is excellent with slight adverse reaction.
  • 药物与临床
    Clinical Observation of Nimodipine on Cerebrovascular Spasm Followed by Subarachnoid Hemorrhage
    LEI Gesheng
    2003, 22(1): 44-45.
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    Objective：To observe the clinical effects and lab changes of nimodipine on vascular spasm followed by subarachnoid hemorrhage. Methods：61 cases of cerebrovascular spasm(CVS) followed by subarachnoid hemorrhage were divided into two groups: 43 cases in the treatment group were given nimodipine 10 mg•d1 by intravenous drip, 18 cases in the control group were given anisodamine 10 mg po, tid. The course of treatment for both groups lasted 14 days. Improvements of symptoms and signs of 43 patients were observed before and after (nimodipine) injection, and blood velocity of MCA was measured during therapy. Results：Compared with control, clinical signs and symptoms were improved notedly in nimodipine patient group; TCD observation found noted difference between the two groups 12 h after the treatment, and the difference continued in 2 weeks. Conclusion：Nimodipine injection given by vein is more effective on CVS followed by SAH than anisodamine taken orally.
  • 药物与临床
    Analysis of Effects of Transfer Factors against Hepatitis B on Chronic Hepatitis B (36 Cases)
    ZHANG Jingliang;TIAN Guizhen;GU Jingjing
    2003, 22(1): 46-47.
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    Objective：To search out the clinical efficacy and side effects of transfer factors against hepatitis B in treating chronic hepatitis B. Methods：68 cases were randomly divided into two groups: 36 cases as the treatment group treated with conventional medicine and transfer factors against hepatitis B and 32 cases as the control group treated with conventional medicine only. Results：There was obvious difference in the changes for liver funcion and signs of HBV. The treatment group got much better results than the control group (P＜0.05). Side and toxic effects have not been found. Conclusion：The method of transfer factors against hepatitis B is safe and effective in treating chronic hepatitis B. So it can be recommended for a wider clinical use
    • 药物制剂
  • 药物制剂
    Preparation and Clinical Use of Zhike Capsules
    ZHANG Xiurong;XU Yingai;FENG Bo;GAO Hongwang
    2003, 22(1): 53-54.
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    Objective：To prepare zhike capsules in which gecko is the main drug and observe their clinical curative effect. Method：The preparation technology and quality standards of zhike capsules were formulated, and the curative effects were observed by treating 63 cases of piles patients who took them orally. Results：The method to distinguish the main drug by thinlayer chromatography (TLC) was simple and practicable. The average recovery of content determination was 99.6%, and the relative standard deviation (RSD) was 2.18%.The effective rates of phaseⅠ, phaseⅡ and phaseⅢ internal piles were 100.0%, 62.5% and 40.0% respectively. Conclusion：The recipe of zhike capsules is reasonable, the methods to control quality are reliable and the curative effects are obvious.
    • 药品质量控制
  • 药品质量控制
    Determination of Paeoniflorin in Gongyankang Granule by HPLC
    XIONG Wenbi;YANG Longhui;XIE Ni
    2003, 22(1): 55-56.
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    Objective：To establish a HPLC method for determination of paeoniflorin in gongyankang granule. Method：The content of paeoniflorin was determined by HPLC, using VYDAC218TP54 column; acetonitrile0.1% phosphoric acid(15∶85) as mobile phase; The detective wavelength was 243 nm.Results：Paeoniflorin at the concentrations of 0.098 2－0.785 6 μg showed good linearity (r＝0.999 7). The average recovery was 103.7% with RSD 2.6%. Conclusion：The results show that the method is simple and accurate. It can be useful in quality control of the products
  • 药品质量控制
    Dualwavelength Ultraviolet Spectrophotometry Determination of the Content in Mouthcleaning Gargle
    MA Pingbo
    2003, 22(1): 57-58.
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    Objective：To establish a method for determination of the content of mouthcleaning gargle. Method：The contents of tinidazol(TN) and chlorhexidine acetate(CA) in mouthcleaning gargle were determined directly by dualwavelength UV spectrophotometry. TN was detected in wave length 317.0 nm(λd) 221.8 nm(λr) and CA was detected in 254.0 nm(λd) 328.2 nm(λr).Results：The average recovery of TN was 100.13% and RSD was 0.64%. The average recovery of CA was also 100.13%, and RSD was 0.78%. Conclusion：This method is fast and accurate, being and suitable to control the quality of the mouthcleaning gargle.
    • 用药指南
  • 用药指南
    郑厚林
    2003, 22(1): 60-61.
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