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    药物研究
  • 药物研究
    TANG Yuenian;ZHANG Shunguo;HONG Lizhen;MA Jiazhen
    2002, 21(12): 762-764.
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    Objective:To test and verify the enzyme responsible for the metabolism of propafenone in combination with lidocaine in human hepatocyte microsomes in an in vitro study. Methods:Propafenone and lidocaine were incubated along with human hepatocyte microsomes and coenzyme factors. The concentration of the drugs and their metabolites were determined by HPLC .The drugs in their original state and their metabolites were compared before and after combination as well as before and after incubation. Results:As shown by Dixon plotting, the combination of the two drugs was in accordance with competitive inhibition. Conclusion:Neurotoxicity of lidocaine may be greatly mitigated by the combined use of propafenone and lidocaine. The combined use of the two drugs, however, should be carried out with extreme caution because of its depressive effect on the heart
  • 药物研究
    XIA Jingmin;CHEN Guijun;LI Fang
    2002, 21(12): 764-765.
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    Objective:To Study the effect of changan (gutsoothing) granules (composed of several traditional Chinese medicinal herbs) on the function of stomach and intestine in the mouse and rat. Method:Changan granules, carbon particles and phenolsulfonphthalein were administered by oral or cecal intubation, respectively to conscious mice and rats. After a definite time period, the ratio of the distance between the leading front of carbon particles in the small intestine and the pylorus to the full length of the small intestine in the mouse, the ratio of the distance between the leading front of carbon particles in the colon and the ileocecal valve to the full length of the colon in the rat, the amount of remnant phenolsulfonphthalein in the stomach of the mouse, the amount of gastric juice and gastric acid secretion as well as the activity of pepsin in the rat, were measured. Phenolsulfonphthalein was determined by ultraviolet spectrophotometry, pepsin activity, with the mett’s method.Results:The aforementioned ratios were increased by changan/granules in doses of 0.25, 0.50, 1.00 g•kg1 in the rat and mouse. The secretion of gastric juice and gastric acid and the activity of pepsin were also increased in the rat. The phenolsulfonphthalein remnant in the stomach of the mouse was decreased 30 min after the administration of changan granules in doses of 0.125, 0.250, 0.500 g•kg1.Conclusion:Changan granules were shown to promote the motility of the stomach, small intestine and large intestine as well as the secretory function of the stomach.
  • 生物制品专栏
  • 生物制品专栏
    DAI Yongan;JIANG Youzhi;NING Yiyun
    2002, 21(12): 766-768.
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    Objective:To survey the shortterm effect of interferonα(IFNα)in the treatment of chromic hepatitis B (CHB) patients infected with HBV precore mutants.Methods:The serum HBVM of patients with CHB were detected with enzyme immunoassay and dot blot hybridization. In the 40 cases positive for HBV replication indices 21 (group A) were infected with the wild type while 19(group B), with the precore mutant type. Patients of both groups were given each IFNαat a dose of 3 000 000 U, i.m., q.o.d. The course lasted 3 or 6 months. Changes in the results of liver function tests and serum HBVM detection were dynamically surveyed.Results:In group A,13 of the 21 cases (61.9%) responded to IFNαtreatment with in 3 months , while only 2 of the 10 cases(10.53%) of group B responded within 3 months. However, 6 of 10 cases (60.0%) who did not respond in 3 months responded when the IFNαcourse was prolonged to 6 months.Conclusion:Patients infected with the mutant type virus could still respond to IFNα. However, the response was weaker than that of patients infected with the wild type virus. These results suggest a prolonged IFNα treatment course for CHB patients infected with the precore mutant type virus.
  • 生物制品专栏
    LI Zhixin;AI Zhilong;XU Chunfang
    2002, 21(12): 768-769.
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    Objective:To survey the therapeutic effectiveness of interferonα in the treatment of epidemic encephalitis B(EEB). Methods:160 cases of EEB were randomly divided into two equal groups: the treatment group 80 cases and control group (80 cases). In addition to the combined treatment including drugs (artificial hibernation),hypothermy with physical measure(ice pillow), antispasm, dehydration, prevention of infection etc. The patients of the treatment group were given each interferonα at a dose of 1×106 U i.m., q.d.. The medication was discontinued after the lady temperature had become normal. The course of interferonα treatment lasted 3-7 days, with an average of 5-7 days. Patients of the control group received the combined treatment only. Symptoms, signs, sequelae and casefatality rate were noted. Results:The incidence of come was significantly lower in the treatment group than in the control group (P<0.05). Besides the results with respect to the time of fever abatement, improvement in lethargy and neck rigidity etc., were also evidently better in the treatment group than in the control group. Casefatality rate of the treatment group (5.0%) was significautly lower than that of the control group(17.5%) (P<0.05). Conclusion:Interferonα was found to have a fairly good therapeutic effect in the treatment epidemic encephalitis B.
  • 药物与临床
  • 药物与临床
    LI Guanghui;CHEN Chao;XIA Renyun
    2002, 21(12): 773-774.
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    Objective:To study the hemorheological changes in patients with lower limb fracture and the influence of shangke boneknitting tablets on hemorrhemorrheology. Methods:25 patients with lower limb fracture were given each 4 shangke boneknitting tablets p.o., t.i.d.. Hemorheological parameters of the patients before the medication and seven days after the termination of treatment were compared with one another and with those of 25 normal people serving as controls. Results:7 days after the termination of treatment, there was a striking decrease in fibrinogen, hematocrit, whole blood reduced viscosity, erythrocyte aggregation index and erythrocyte sedimentation rate. In contrast, the erythocyte deformability index was evidently increased. The differences were significant (P<0.05) or highly significant (P<0.01) when these parameters were compared with those of the patients before the medication. The differences, however, were insignificant when the parameters of the patients after the treatment were compared with those of the normal controls (P>0.05). Conclusion:Shangke boneknitting tablets were shown to be capable of obviously improving the hemorheological status, promoting bony union and preventing lower limb deep venous thrombosis in patients with lower limb fracture.
  • 药物与临床
    JIN Min;FANG Zhen;LUO Ailin
    2002, 21(12): 775-776.
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    Objective:To assess effects of total intravenous anesthesia(TIA) with combination of propofol, ketamine, and fentanyl in radical surgery for breast cancer. Methods:TIA with continuous infusion of propofol, ketamine, fentanyl by pump was employed in 30 patients undergoing radical operation for breast cancer during which spontaneous respiration of the patients was maintained by mask ventilation supplemented with nasopharyngeal airway. The arterial blood pressure dropped markedly after bolus injection of propofol(P<0.01). However, at the moment of and 5 min after skin incision, the blood pressure rose to a level apparently higher than that before anesthesia(P<0.05) and subsequently became stable 20 min later. In finally returned to the preanesthetic level after TIA had been discontinued. The incidence of transient apnea resulting from bolus intravenous injection of propofol at a dose of 1 mg•kg1 was about 21.0%. Spontaneous respiration recovered after assisted ventilation, during which SpO2 was maintained at values higher than 98.0%.Results:Of arterial blood gas analysis were within normal ranges although PaCO2, TCO2, HCO-3 were slightly increased in comparison with preanesthetic values. Spontaneous recovery of consciousness occurred 5-35 min after discontinuation of TIA. The patients were quiet, felt no pain and had no adverse reactions.Conclusion:The abovementioned TIA has the advant ages of rapid induction, stable maintenance of and early awakening from anesthesia. It is also to avoid a series of severe complications resulting from endotracheal intubation.
  • 药物与临床
    CHEN Yunping;MEI Yuanwu;CHENG Shiqing
    2002, 21(12): 777-778.
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    Objective:To survey the therapeutic effect of nicergoline (Sermion) on the disorder of cognitive function in patients with multiinfarct dementia (MID).Method:32 patients with MID were given each nicengoline at a dosage of 10 mg t.i.d. per os for 3 consecutive months.Results:The mean MMSE score reflecting the cognitive function of the patients with MID was significantly increased (P<0.01) after nicergoline treatment, as compared with that before the treatment. The total effective rate was 84.4%. Conclusion:Nicergoline was shown to be an effective drug for improving the cognitive function of patients with MID.
  • 药物与临床
    LING Xiang;JIN Yan;CHEN Weiming
    2002, 21(12): 778-779.
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    Objective:To appraise the effect of caoshanhu (CSH) oral plaster in the treatment of recurrent oral ulcers (ROU). Methods:102 patients with ROU were randomly divided into 2 groups. 52 patients of the treatment group were treated by local painting with CSH oral plaster t.i.d or b.i.d. while 50 patients of the control group, with metronidazole plaster, t.i.d or b.i.d., as well. Thera peutic effectiveness in patients of both groups was kept under observation in different time periods during the treatment and an oneyear followup survey carried out for the occurence of relapse of oral ulcers. Results:The numbers of cases found to be “strikingly effective”, “effective” and “ineffective” in the treatment group were 27,25 and 0, respectively. The overall effective rate was 100.0%. In contrast, those parameters in the control group were 15, 24 and 11, respectively, the overall effective rate being 78.0%. The effect was significantly better in the treatment group (P<0.05). No adverse reactions were noted except that two patients of the control group complained of local stabbing pain. Conclusion:CSH oral plaster was shown to have good clinical therapeutic effect in the treatment of ROU.
  • 药物与临床
    DAI Xiaofang;WEI Dunshuang;YANG Shuisheng
    2002, 21(12): 780-781.
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    Objective:To study the therapeutic effect iveness of intrapleural administration of bleomycin in the treatment of maligant pleural effusion. Methods:52 patients with malignant pleural effusion served as subjects of the study. After the pleural effusion had been drained off as fully as possible by needle aspiration or trocar puncture, the patients were given each an intrapleural inyection of bleomycin at a dose of 30~40 mg•(m2)1, once weekly, each patient receive 1 or 2 times. The therapeutic effectiveness and adverse reactions were kept under observation. Results:The overall effective rate was 82.7%(CR=26, PR=17, NC=9). The main adverse reactions including fever, chest pain and nausea were generally tolerable. Conclusion:The therapy is fairly effective in the management of malignant pleural effusion. Adverse readions are mild and tolerable.
  • 药物与临床
    MA Pingbo
    2002, 21(12): 781-782.
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    Objective:To study the analgesic effect of ketorolac tromethamine (KT) in the treatment of pain in patients with surgical diseases. Method:118 patients complaining of pain due to surgical diseases served as the subjects of the study. To each of these cases, 30 mg of KT were administered i.m. and 10-20 mg p.o.. The maximum daily dosage was not allowed to exceed 120 mg. Patients with severe pain that could not be relieved 30 min after the first medication were given each an additional dose of 30 mg of KT i.m. Results:The time of initiation of the effect was 5-60 min, with an average of 35 min. The analgesic effect lasted 0.5-24 h, with a mean of 8.2 h. The overall effective rate was 97.5% (115/118). Conclusion:Ketorolac tromethamine was shown to have a striking analgesic effect. The drug also started to act very soon. It is therefore suggested by the authors to use the drug for relieving pain associated with different clinical diseases
  • 药品质量控制
  • 药品质量控制
    LUO Mingzhu;ZHANG Hong
    2002, 21(12): 801-802.
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    Objective:To set up a method for the determination of emodin content in qingremingmu capsules. Method:In the TLC assay, a 0.5% carboxymethyl cellulose sodium silica gel G plate and a devoloping solvent with a mixture of benzeneethyl formateformic acidmethanolwater (3∶1∶0.05∶0.1∶0.5) as the upper solution were used. λS=435 nm, λR=530 nm. Results:A good linear relationship was found when the sample amount ranged between 0.168-3.09 μg. The regression equation was as follows: Y=105 417.7X1 115.6, r=0.999 5. The average rate of recovery was 100.53%, RSD=3.38%. Conclusion:The method is simple, convenient, and accurate
  • 药品质量控制
    ZHOU Qun;XU Laying
    2002, 21(12): 802-803.
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    Objective:To determine the content of gallic acid in chuxueting oral liquids. Method:The chuxueting oral liquid was dissolved in distilled water, and then extracted with watersaturaled nbutanol etc. for the preparation of samples. The samples were subjected to gallic acid determination by TLC scanning(λS=280 nm,λR=350 nm). Results:The average rate of recovery was 96.36%, RSD=2.39%. The contents of gallic acid in 3 batches of samples were 0.38,0.42 and 0.47 mg•mL1 respectively. Conclusion:The method is simple, convenient and feasible.
  • 药物制剂
  • 药物制剂
    FENG Bo;ZHANG Zhenjia;HE Zhonggui;LI Dihui;ZHANG Wenxi
    2002, 21(12): 807-808.
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    Objective:To plot the solubility curve of salbutamol (SAL) in ethylated βcyclodextrin (ECD) solution of and to determine the constitutive molar ratio of salbutamolethylated βcyclodextrin (SALECD) inclusion compound and its stability constant.Method:The constitutive molar ratio of SALECD inclusion compound was determined by continuous variation plotting while its stability constant was determined by measuring absorbance. Results:The constitutive molar ratio of SAL to ECD inclusion compound was 1:1, and stability constant of the inclusion compound was 4 564 L•mol1. The solubility of SAL in ECD solution decreased with the increase of the concentration of ECD. Conclusion:A relatively stable inclusion compound of SAL and ECD (1∶1) can be formed.
  • 药物制剂
    LI Huakang;LAO Jianchun
    2002, 21(12): 809-810.
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    Objective:To find out the correlation between the time limit of collapse of the doublelayered pills and the coating technology by studying the time limit of collapse of bupiyichangwan produced from using different coating materials in different ratios. Method:Spraying technology was adopted in the preparation of coating. Screening of formulas and technologies was used to find out the suitable pill diameter, coating thickness, kinds of coating materials and their ratios. The improved technology adopted eudragit Ⅱ in suitable proportion as the material for coating production. Results:This progress in technology has got rid of the trouble that the pills produced according to the traditional technology cannot readily break down in the intestinal fluid. The time limit of coating collapse was shortened from (59.5±2.6) min to (20.5±2.1) min. The rate of product qualification was 100.0%. Conclusion:The improved coating technology is easy to operate of lowcost and has provided scientific basis for the preparation and development of doublelayered pills.
  • 药物制剂
    LIU Zuxiong;WANG Ping;LI Xiaodong;TANG Ren
    2002, 21(12): 810-811.
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    Objective:To study the preparation and quality standard of clarithromycin ointment. Method:To 10 g of clarithromycin and 50 g of liquid paraffin, white vaseline qs was added until a total weight of 1 000 g was reached. The mixture was sterilized by dry heat at 150℃. The procedure was finished after stirring and cooling. The content of clarithromycin in the ointment was determined by antibioticsmicrobes assay. The stability and irritating character were also tested. Results:The ointment was stable, and its quality controllable. Conclusion:The technodogy of the preparation of clarithromycin ointment was simple. The drug was also easy to use. It is therefore worth spreading its clinical application.