药物研究
XIA Jingmin;CHEN Guijun;LI Fang
2002, 21(12): 764-765.
Objective:To Study the effect of changan (gutsoothing) granules (composed of several traditional Chinese medicinal herbs) on the function of stomach and intestine in the mouse and rat. Method:Changan granules, carbon particles and phenolsulfonphthalein were administered by oral or cecal intubation, respectively to conscious mice and rats. After a definite time period, the ratio of the distance between the leading front of carbon particles in the small intestine and the pylorus to the full length of the small intestine in the mouse, the ratio of the distance between the leading front of carbon particles in the colon and the ileocecal valve to the full length of the colon in the rat, the amount of remnant phenolsulfonphthalein in the stomach of the mouse, the amount of gastric juice and gastric acid secretion as well as the activity of pepsin in the rat, were measured. Phenolsulfonphthalein was determined by ultraviolet spectrophotometry, pepsin activity, with the mett’s method.Results:The aforementioned ratios were increased by changan/granules in doses of 0.25, 0.50, 1.00 g8226;kg1 in the rat and mouse. The secretion of gastric juice and gastric acid and the activity of pepsin were also increased in the rat. The phenolsulfonphthalein remnant in the stomach of the mouse was decreased 30 min after the administration of changan granules in doses of 0.125, 0.250, 0.500 g8226;kg1.Conclusion:Changan granules were shown to promote the motility of the stomach, small intestine and large intestine as well as the secretory function of the stomach.