激素及影响内分泌的药物专栏
WU Xiaoyun;LI Jucheng;WANG Jianhua;ZHANG Guoxing
2002, 21(08): 489-490.
Objective:To survey the effects of recombinant human growth hormone (rhGH) on the protein metabolism, healing of wound surface, antiinfective capability and prognosis in adult patients with severe burns. Methods:36 patients with severe burns with wound surfaces covering more than 60% of total body surface area (TBSA) were enrolled in this placebocontrolled prospective study. They were comparable in nutrient intake, TBSA, and full thickness burn areas. Patients of both the treatment group and control group were subjected to supportive therapy with nutrients, surgical operation and antiinfective management. 18 patients of the treatment group were given each rhGH subcutaneously in a dose of 0.2 U•kg1 at 8 am each morning for 10~20 consecutive days beginning from postoperation day 1. Patients of the control group were given normal saline as placebo. The general condition, protein catabilisn, healing time of wound area and autologous skindonor site healing rate of the total wound surface on the 30th day after burn and duration of hospitalization of patients of the two groups were compared. Results:In patients of the treatment group, there was a better general condition, smaller decrease in body weight and smaller amount of antibiotics needed postoperatively. The duration of the use of the healing time of autologous skin pulp grafting and donor sites, and the period of hospitalization in patients of the treatment group were significantly shorter than those in patients of the control group. Conclusion:rhGH was found to promote protein anabolism, shorten the time of wound surface healing, enhance immunity and shorten the period of hospitalization in patients with severe burns.