皮肤病性病用药专栏
WU Yan;TAN Zhijian;LIU Zhixiang
2002, 21(06): 348-349.
Objective:To compare the clinical efficacy of mizolastine (M) and cetirizine (C), terfenadine (T), loratadine (L) in the treatment of acute urticaria. Methods:Volunteers were divided into the following groups: group M (10 mg, po, qd, 37 subjects), group C (10 mg, po, qd, 35 subjects), group T (60 mg, po, bid, 34 subjects), group L (10 mg, po, qd, 34 subjects). The efficacy was evaluated at one hour, three and six hours, twentyfour hours after oral intake of the various drugs. Results:The effect was quicker and stronger in group M than that in groups C, T and L(P<0.05) after 1 hour. The effect was similar in groups M, C and T after 3 and 6 hours (P>0.05), but all stronger than group L (P<0.05). The effect was similar in groups M, T and L after 24 hours (P>0.05), but all stronger than group C (P<0.05). Conclusion:Misolastine is a quickacting and ultralente drug for acute urticaria. It is worthwhile to be used clinically.