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    药物研究
  • 药物研究
    Experimental Study of the Acute Toxicity of the Zedoary Turmeric Oil Gelatin Microsphere
    DENG Shigui;MO Lili;OU Yongquan;OU Runmeic
    2002, 21(04): 200-202.
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    Objective:In order to observe the safety of a special preparation formzedoary turmeric oil gelatin microspheres (ZTGMS) for interventional therapy, we studied the acute toxicity of ZTGMS. Methods:ZTMGS was administered through the proper hepatic artery, the manifestations of acute toxicity was observed for 14 days, the biochemical indices of blood tested, and the LD50 calculated with Bliss method. Results:The LD50 of ZTGMS administered via proper hepatic artery was 17.19 mg•kg1, the GPT、GOT、TBiL、DBiL、BCr and BUN of the dead animals were significantly increased, while changes of the biochemical indices in the survived animals were not significant. The results of the histopathological examination suggested the possibility of dystopic embolism occurrence in animals administered with ZTGMS. Conclusion:The study indicated that the acute toxicity of ZTGMS might result from the dystopic embolism rather than the oil of zedoary turmeric itself entrapped in ZTGMS.
    • 感染性疾病用药专栏
  • 感染性疾病用药专栏
    A Randomized Controlled Clinical Trial of Dexketoprofen Entericcoated Tablet Versus Ketoprofen Tablet in Treatment of Common Cold
    WU Xiaochun;LI Qing;ZHONG Mingyuan;YU Airong;XIN Huawen;ZHU Min;LI Zhigang
    2002, 21(04): 203-204.
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    Objective: To evaluate the clinical efficacy and safety of dexketoprofen entericcoated tablet in cold treatment. Methods:All the patients recruited were randomized into the trial and control groups, and treated with dexketoprofen entericcoated tablet and ketoprofen tablet, respectively. The analgesic efficacy and adverse reaction were observed. Results:The effectiveness rates in the trial and the control groups were 90% and 85%, while the incidence of adverse reaction in the two groups 10% and 20%, respectively. There were no significant differences between the two groups (P＞0.05). Conclusion:Dexketoprofen entericcoated tablet is an effective and safe agent for treating the common cold.
  • 感染性疾病用药专栏
    Clinical Effectiveness of Penciclovir Ointment for the Treatment of Facial Herpes Simplex: A Report of 35 Cases
    LIU Houjun;TU Yating;LIU Zhixiang
    2002, 21(04): 205-206.
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    Objective:To observe the efficacy and safety of 1% penciclovir ointment in treating the facial herpes simplex.Methods:Using a doubleblind and randomized controlled trial design, a total of 68 patients with facial herpes simplex were divided into two groups, 35 patients in the treatment group treated with 1% penciclovir ointment, while the other 33 in the control group with 3% acyclovir ointment. Results:It was found that the time needed for stopping occurrence, scab and complete resolution of vesicle, as well as for resolution of symptoms and complete recovery in the treatment group was significantly shorter than that in the control group (P＜0.05). And no side effect was noted.Conclusion:Using 1% penciclovir ointment for the treatment of facial herpes simplex can be of high effectiveness and considerable safety.
  • 感染性疾病用药专栏
    The Bacteriology and Drug Sensitivity Analyses of 50 Outpatients with Skin and Soft Tissue Infection
    GAO Wei;BAI Xiangjun
    2002, 21(04): 206-208.
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    Objective:To provide a guidance for clinical treatment of outpatients with skin and soft tissue infections through pathogen detection and drug sensitive test. Methods:The pus or wound secretion of 88 outpatients with skin and soft tissue infection was collected, bacteria culture was performed and pathogen identification as well as drug sensitivity done. Results:Of the samples from 88 patients, 50 were positive in regard to bacteria culture. Staphylococcus was the major pathogenic bacteria which was highly sensitive to cephalosporin and the third generation of quinolone. Conclusion:The first selection of antibiotics for treating skin and soft tissue infections should be, according to the observations of this study, cephalosporin or quinolones; and great attention should be payed to the infection caused by conditioned pathogens.
  • 感染性疾病用药专栏
    Effcet of Alprostadil in the Treatment of Severe Chronic Hepatitis B
    SONG Jianxin;WANG Weihua;CHEN Hongyun;QI Junying;HUANG Yuancheng;ZHANG Zhengang
    2002, 21(04): 208-209.
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    Objective:To observe the effect of alprostadil in the treatment of severe chronic hepatitis B. Methods:84 patients with severe chronic hepatitis B were randomized into the trial and control groups. 46 patients in the trial group were given alprostadil, 20 μg•d1, for two weeks, in addition to routine management, while the 38 cases in the control group were given routine treatment. During the period of the treatment, patients signs, symptoms and liver function indices were observed. Results:Compared with the control group, the symptoms and signs were improved significantly in 46 patients in the trial group, especially in those with chronic severe hepatitis B. The effective rate was significanly higher in the trial group than that of the control group (P＜0.01). Conclusion:Alprostadil had considerable effects in treating severe chronic hepatitis B.
    • 药物与临床
  • 药物与临床
    Effect of Pinyangmycin in Combination of Other Drugs in the Treatment of Cavernous Hemangioma in Maxillofacial Region
    HU Qiang;ZHANG Zhihong;WANG Xiurong
    2002, 21(04): 214-215.
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    Objective:The purpose of this study is to assess the effect of local injection of pinyangmycin mixed with dexamethason and sodium morrhuate for treating cavemous hemangioma in the maxillofacial region. Methods:58 patients with cavemous hemangioma in the maxillofacial region were recruited for this study. 8 mL of pinyangmycin was dissolved in 1 ml (5 mg) of dexamethason, and then mixed with 4ml of 1% procaine. 1～5 mL (pinyangmycin 1.6～8.0 mg) of the aforementioned mixed solution was injected into the hemangioma, followed by an injection of 0.5～2.0 mL of sodium morrhuate, according to the local appearance, size of the tumor and patient’s age. Generally, the amount of each injection should not be over 8 mg of pinyangmcin. If the tumor did not subside after an injection, another injection might be repeated every 5～7 days, and this process might be repeated 3～5 times. However, the total dose of pinyangmcin should not be over 40 mg. Results: The 58 patients were followed up for two years. 43 out of the 58 (74.14%) patients recovered completely, 12 (20.69%) recovered nearly completely, and 3 (5.17%) improved to some extend. The total effectiveness rate was 100%. Conclusion:Using pinyangmycin in combination with dexamethason and sodium morrhuate for local injection is an effective and safe method for treating hemangioma in the maxillofical region.
  • 药物与临床
    A Clinical Evaluation of Effectiveness of Basic Fibroblast Growth Factor in Promoting Wound Healing
    LI Guanghui;ZOU Yun;XIA Renyun
    2002, 21(04): 215-217.
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    Objective:To evaluate the effects of basic fibroblast growth factor (bFGF) on wound healing and the sideeffects of bFGF. Methods:In this study, 173 patients with various kinds of wounds were recruited and randomly divided into treatment and control groups. The 89 patients (55 with acute wounds and 34 chronic intractable wounds) in the treatment group were treated with local use of bFGF in addition to routine management, while the 84 patients in the control group treated only with routine management. Results:It was found that the time needed for wound healing for those in the treatment group was significantly shorter than that in the control group. Meanwhile, no adverse effect was found in any patients treated with bFGF. Conclusion:bFGF can promote the repairing of wounds.
  • 药物与临床
    Filgrastim Accelerating the Recovery of Chemotherapyinduced Reduce of Neutrophilic Granulocytes in Patients with Malignant Lymphocytosis
    WANG Ping;MU Yingxin
    2002, 21(04): 217-218.
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    Objective: To observe the effect of filgrastim in the recovery of chemotherapyinduced reduce of neutrophilic granulocytes. Methods:40 patients suffered from malignant lymphocytosis were treated with the EACOP or VDPL protocol and then with intravenous injection of 150 μg of filgrastim for 5 days, or sc for 4～14 days. The concentration of the serum GCSF was measured and the AKP integral of bone marrow calculated.Results:Compared with the control group, the time needed for the recovery of decreased number of the neutrophilic granulocytes was shorter in the treatment group (P＜0.05), and the incidence of infections lower P＜0.05. However, the death rate during chemotherapy remained the same. Increased AKP intigral of bone marrow and the serum GCSF concentration were observed in some patients. Conclusion:Filgrastim has a significant effect in promoooting the recovery of neutrophlic granulocytes and very mild side effects.
  • 药物与临床
    The Combined Use of Drugs for Treating Peptic Ulcer: A Report of 233 Cases
    WANG Heping
    2002, 21(04): 219-220.
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    Objective:To study the effect of combined use of drugs in treatment of peptic ulcer.Methods:233 gastroscopically confirmed peptic ulcer patients were included in this study(DU, duodenal ulcer 161; GU, gastric ulcer 72, malignant GU was excluded through pathological examination) and tested with HP(first with RUT, if postive with 14CUBT). Four drugs were simadtaneously administered to the patients according to the following regime: Delo 100 mg, four times a day; Omeprazole 20 mg,once a day; amoxycillin 0.5 g, four times a day; metronidaxole 0.4 g ,twice a day, for 2 weeks. All the patients were examined 4 weeks later with gastroscope and 14CUBT.Results:The postive rate of HP in DU was 95.7% and 80.6% in GU. The curative rate of DU were 91.3% for DU and 86.1% for GU, HP eradication rate was 93.0% in DU and 91.4% in GU. There was no significent difference(P＞0.05) between DU and GU. Liver and renal functions were normal after treatmnet. Conclusion:HP has a close relation with peptic ulcer. The combined use of Delo、Omeprazole、amoxycillin and metronidazole is significantly effective for treating PU. Meanwhile, the 14CUBT examination is very sensitive and specific for detecting the HP positive cases of PU.
    • 药品质量控制
  • 药品质量控制
    Quality Evaluation of Zhengqiyang Mixture
    DING Shuiping;MA Baoxia;FANG Jianguo;ZHANG Rui
    2002, 21(04): 234-236.
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    Objective:To establish a method for quality evaluation of Zhengqiyang mixture mainly composed of Radix Astragali and Radix Acanthopanacis Senticosi. Methods:The preparations of Radix Astragali and Radix Acanthopanacis Senticosi were selected as the control samples. The thin layer chromatography (TLC) was employed to characterize the control as well as the main components of Zhengqiyang mixture. The modified phenol sulfate method was used to quantitate polysaccharides in the preparations in conjunction with spectrophotometry. Results: Spots in the diagram of TLC were clear and the spot of astragaloside A showed purple with Rf＝0.58, T＝20℃ and RH＝67; Meanwhile, TLC performed to identify Radix Acanthopanacis Senticosi showing that the target spot was blue with Rf＝0.78,T＝25℃ and RH＝70%. The absorptions of processed samples were tested at the wavelength of 488 nm by phenol sulfate. The average recovery was 97.94% with RSD of 2.33%, the measured contents of polysaccharides in 6 batches of preparations were equivalent to 20～40 mg•ml1 of glucose.Conclusions: TCL can be applied for identifying the main components of the mixture, and the content of polysaccharides in the products can be measured by the modified phenol sulfate method.
  • 药品质量控制
    Testing the Content of Klindamycin Hydrochloride Gel Using High Performance Liquid Chromatography
    PING Chengbin;SONG Hongping;CHEN Guanrong
    2002, 21(04): 236-237.
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    Objective:To establish the regime of testing the content of klindamycin hydrochloride gel by using high performance liquid chromatography (HPLC). Method:The mobile phase of the HPLC is composed of pH 7.5 potassium dihydrogen phosphate solution and acetonitrile (55∶45), the wavelength of the ultraviolet employed for test is 214 nm.Results:The sample resolution was very good, the withinday and betweenday accurate RSDs were 0.7%～1.1% and 0.9%～1.4%, respectively. The average recovery was 99.7% (n＝5), RSD 1.2%, the lower detection limit was 0.25 μg•ml1. Conclusion:The method is simple, rapid, accurate and has good resolution. It is suitable for routine analysis of the klindamycin hydrochloride gel.
    • 药物制剂
  • 药物制剂
    Optimization of the Extraction Method of Paishi (Lithagogue) Mixture with Orthogonal Design
    GE Shengrong;WANG Pingquan;AN Furong
    2002, 21(04): 239-240.
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    Objective: To optimize the extraction method of Paishi (Lithagogue) mixture.Method:With the amounts of total solid substance and total flavone as indexes, the extraction methods were screened by orthogonal design. Results: The sequence of factors influencing the indexes was as follows A＞C＞B, (A: the amount of water added, B: the time of soaking, C: the time of decoction). Only the factor A affected the indexes significantly.Conclusions:The optimal extraction process obtained was: The drugs were decocted twice. For the first decoction, 12 volumes of water were added to 1 volume of the traditional Chinese medicinal materials and the extraction lasted 1 h after boiling. In the second decoction, the ratio of water added to the drugs was 10∶1 and the extraction time after boiling was 1/2 h.
    • 用药指南
  • 用药指南
    An Analysis of the Use of the Lipidlowering Agents Drugs in a Large General Hospital
    ZHUANG Hualing;LI Ruizhen
    2002, 21(04): 242-243.
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    Objective:To find out the current situation and tendency of the use of the lipidlowering agents in the authors’ hospital and to provide guideline for rational use of drug. Methods:The data regarding the use of lipidlowering agents in the authors’ hospital during 19992000 were collected and analyzed in respect to the total expense, the order of DDDs, pharmacological classification and source of drug. Results:The annual rates of increase was 36.18% for the total expense for drug consumption, 19.09% for the DDDs of lipidlowering agents and 74.04% for the DDDs of 3hydroxyl3methylglutary CoA reductase inhibitors, respectively. Conclusion:The average daily expense for lipidlowering agents in the authors’ hospital was irrationally high.
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