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    药物研究
  • 药物研究
    Screening of Chemical Constituents with Antiendotoxin Activity from Radix Isatidis
    LIU Yunhai;QIN Guowei;FANG Jianguo;WU Xiaoyun
    2002, 21(02): 74-75.
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    Objective:To screen the antiendotoxin activities of the 31 chemical compounds isolated from Radix Isatidis.Methods:A sterile aqueous solution of each of the 31 compounds was prepared at a concentration of 1 mg solute•mL1 . All these solutions were subjected to the endotoxin assay according of the Pharmacopeia of the People’s Republic of China. Those found to be active were coincubated with endotoxin which was capable of inducing typical fever reaction in rabbits. Folutions with antiendotoxin activity were then submitted to in vivo pyrogen assay according to the Pharmacopeia of the People’s Republic of China. Results:Six compounds were shown to have antiendotoxin activity in vitro. One of these six compounds was found to have a semiin vivo antiendotoxin activity. Conclusion: Compounds with antiendotoxin activity may be screened out from the chemical constituents isolated from Radix Isatidis.
  • 药物研究
    Effects of Glochidion Puberum on the Production of TNFα and IL6 in Macrophage from Mice with Ulcerative Colitis
    DING Shuiping;DING Shuisheng;LI Hanzhi
    2002, 21(02): 76-77.
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    Objective:The aim is to study the effects of the extract from Glochidion Puberum (GP) on the production of TNFα and IL6 in macrophage from mice with ulcerative colitis (UC) induced by.Methods:The animal model of UC was made by filling the 5% CH3COOH solution to the colon of 10 mice, who were randomly allocated to the control and treatment groups. 5 normal mice were used as normal control. 10 ml of normal saline were fed to the control and the normal control mice, twice a day for a total of 3 weeks before sacrifice. The same amount of Glochidion Puberum extract was fed to the mice in treatment group for the same period of time. The ELISA method was employed to measure TNFα and IL6.Results:The contents of TNFα and IL6 were 0.49±0.32 and 0.37±0.15, respectively in the control group and significantly lower than those in the controls. However, no significant difference was found between the control and the normal control mice. Conclusion:GP can significantly lower the TNFα and IL6 in mice with UC and might be effective for treating UC.
    • 儿科用药专栏
  • 儿科用药专栏
    An Observation of the Effects of Topiramate in Treatment of Juvenile Epilepsy
    LIU Zhisheng;WANG Fanglin;YANG Lizhi;HU Jiasheng;WU Gefei
    2002, 21(02): 78-79.
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    Objective:To evaluate the effects and safety of topiramate (Topamax) in treatment of juvenile epilepsy. Methods:Thirtytwo children (M 24, F 8) with epilepsy between the ages of 5 months and 11 years were treated with topiramate. The starting dosage was 0.8～1.2 mg•kg1•d1, bid, and the target dosage 4～9 mg•kg1•d1, bid. The followup period ranged from 3 to 9 months. Results:The total effective rate of topiamate was 71.9% and the adverse effect was minor. Conclusion:Topiramate is effective for juvenile epilepsy, and well tolerated by the children.
  • 儿科用药专栏
    The Efficacy of Atrovent in Treatment of Juvenile Asthmawith a Report of 36 Cases
    DING Weixiu;LI Jie;JIANG Rong
    2002, 21(02): 80-81.
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    Objective:To assess the efficacy of atrovent (Ipratropium bromide) and ventolin (Salbutamol) in treating the acute attacks of asthma in children less than three years. Methods:68 cases were recruited and randomly divided into the treatment group (36 cases) and control group (32 cases). Inhalation of ventolin plus atrovent was administered to those in the treatment group, and ventolin the control group, respectively for a total of 3 to 7 days. Both groups received conventional treatment as well. Results:It was showed that the curative rate was 94.4% in the treatment group versus 66% in the control group (P＜0.05). The average time for relief of short of breath was 2.96±1.2 versus 4.18±1.24 days (P＜0.01), the time for disappearance of wheeziness was 3.06±1.40 versus 4.59±1.72 days (P＜0.01). Conclusion:The combined use of ventolin and atrovent is more effective for treating asthmatic children than the use of ventolin only.
  • 儿科用药专栏
    An Observation of the Effects of Methylprednisolone on Acute Attack of Asthma to Children
    ZHUO Zhiqiang;CHEN Zhihong;ZHEN Jingyang
    2002, 21(02): 81-82.
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    Objective:To compare the effects of methylprednisolone and dexamethasone on the acute attack of asthma to children. Methods:79 cases were recruited for this study and divided in the treatment and control groups. 37 cases in the treatment group were given methylprednisolone with intravenous injection of a dosage of 1～2 mg•kg1, twice daily, while 42 cases in the control group given dexamethasone with a dosage of 0.3～0.5 mg•kg1, twice daily. The effects were observed 48～72 hours after administration of the drugs.Results:It was found that the pulmonary function was better after treatment in both groups than that before the treatment (P＜0.05). A greater change was noticed in the treatment group (P＜0.01). In the treatment group, obvious effects were observed in 20 cases (54.1%), some effects in 16 cases (43.2%), and no effect in 1 cases (2.7%). In the control group, obvious effects were observed in 11 cases (26.2%), effects in 24 cases (57.1%), and no effects in 7 cases (16.7%). The clinical effects achieved in the treatment group are much better than that in the control group ( P＜0.05). Conclusions: Methylprednisolone is significantly effective in the treatment of the acute attack of acute asthma to the children. We recommend it in clinical practice.
  • 儿科用药专栏
    A Study of the Clinical Effects of Shenfu for Treatment of Juvenile Asthma
    ZHANG Jianyi;LIU Aiguo
    2002, 21(02): 83-84.
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    Objective:To investigate the clinical value of shenfu, a drug made from traditional Chinese herbal medicine for treating the juvenile asthma. Methods: A total of 72 cases of juvenile asthma were recruited and randomly divided into treatment and control groups. Those in the control group were treated with conventional regime, while those in the treatment with conventional regime plus intravenous administration of Shenfu injection. Various clinical parameters were observed before and after the treatment in both groups. Results:The improvement of clinical symptoms and signs, course of treatment, blood serum IgG and CD3 、CD4、CD8 in T lymphocytes and arteria PO2、SaO2 were greater in the treatment group than those in the control group. Conclusion:Shenfu has significant effects in improving clinical symptoms and signs, it can shorten the duration of illness and help regulate the function of humoral and cellular immunity.
    • 药物与临床
  • 药物与临床
    Clinical Analysis of the Therapeutic Effect of Imipenem in the Treatment of Severe Infection of the Lower Respiratory Tract
    ZHANG Jianchu;XIN Jianbao;LI Yuangui
    2002, 21(02): 90-91.
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    Objective:To find out the therapeutic effect and safety of imipenem in the treatment of severe infections of the lower respiratory tract (LRT). Methods: A retrospective analysis was made concerning the therapeutic effects and adverse reactions of imipenem in the treatment 16 cases of severe infection of the LRT.Results: The treatment was effective in 14 of the 16 cases, the effective rate being 87.5%. Among the 9 strains of bacteria isolated, 7 were cleared (77.8%) after the treatment, the remaining 2 strains were methicillinresistant staphylococcus aureus (MRSA) and pseudomonas aeruginosa, respectively. No other adverse reactions were observed except for 1 case with mild dizziness and nausea.Conclusions: Imipenem is a safe and effective remedy for the treatment of severe bacterial infection of the LRT. In particular, it is recommended for treatment of mixed bacterial infections of the LRT or for infections caused by unidentified pathogens.
  • 药物与临床
    The Use of Shenmai Injection for Hypotension of Patients with Uremia during Nondialysis Phases
    LIU Li;SONG Jing;LIU Baohong;WU Jieru;JIN Yonghong
    2002, 21(02): 93-94.
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    Objective:To study the use of Shenmai injection in the treatment of hypotension during nondialysis phases in uremic patients under maintenance hemodialysis and in the improvement of hemodialysis tolerance as well as the quality of hemodialysis. Methods:16 uremic patients with hypotension were give 40 mL of Shenmai injection through intravenous drip, once daily for a period of two weeks. The blood pressure and the urea clearance rate (Kt/V) as well as the quality of hemodialysis of the subjects were observed before and after the treatment.Results:It was showed that, the mean systolic and diastolic blood pressures, as well as the Kt/V, before versus after the treatment, were (85.79±10.38) mmHg versus (124.28±12.18) mmHg, (54.96±9.70) mmHg versus (76.84±7.74) mmHg (P＜0.01), 1.05±0.27 versus 1.54±0.23 (P＜0.01). Conclusion:The use of Shenmai injection corrected the hypotension in uremic patients under maintenance hemodialysis, and thus the hemodialysis therapy was assured, and the quality of hemodialysis improved.
    • 药品质量控制
  • 药品质量控制
    Determination of Synthetic Pigments in Hospital Preparations by HPLC
    SHEN Lijun;YANG Jiangfeng
    2002, 21(02): 107-108.
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    Objective: To determine synthetic pigments in hospital preparations with the use of HPLC.Methods:Synthetic pigments frequently used in hospital preparations were simultaneously separated on a Kromasil C18 column with acetonitrilephosphate buffer solution(pH:6) as the mobile phase, the detector wavelength being 254 nm. Results:To separate pigments at a wavelength of 254nm is a simple and convenient, rapid and accurate method with a high separation nate.Conclusion: The finding of superstandard amounts of synthetic pigments in hospital preparations is relatively common.
  • 药品质量控制
    Study Stability of the Indomethacin Gel
    CHEN Zhanghe
    2002, 21(02): 108-109.
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    Objective:To study stability of the indomethacin gel. Methods:The indomethacin gel was put in high temperature, high humidity and under strong light with or without package. The variation of its quality was studied.Results:The strong light caused a slight decrease of the quality of the unpacked indomethacin gel; The high temperature (80℃) caused significant decrease of quality of bothe packed and unpacked indomethacin gel. However, the quality was not affected by the high humidity. Conclusion:Indomethacin gel is unstable, slightly unstable, highly stable in high temperature, under strong light and in high humidity, respectively. Indomethacin gel must be coated in lower temperature and be kept away from strong light.
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