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    特约稿
  • 特约稿
    Quantitative Determination of Bacterial Endotoxin in Metronidazole Injection and Its Relative Problems
    Pan Mingchen;Sun Suyan
    2000, 19(3): 203-204.
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    Objective:The quantitative determination of bacterial endotoxin in metronidazole injection was introduced and
    its relative problems were discussed.Methods:The bacterial endotoxin in metronidazole injection was quantitatively
    determined by the bacterial endotoxin test and affinity membrane isolating method, 0.2% metronidazole injection diluted
    5time was determined, 0.5% metronidazole injection diluted 13time was determined (sensitivity of tachypleus
    amebocyte lysate was 0.125 EU/ml).Results:Affinity membrane isolating method was similar to bacterial endotoxin
    test.Conclusion:Affinity membrane isolating method is accurate and dependable, simple and quick in clinical application.
    • 药物研究
  • 药物研究
    Hypotensive Effect of Stevioside on Rat and Dog
    Xia Jingmin;Xu Deyi;Lu Pengyi;
    2000, 19(3): 205-206.
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    Objective:To evaluate the effect of stevioside against hypertension.Methods:The characterically hypotensive effect of intravascular stevioside on concious and anesthetized spontaneously hypertensive rats was studied. The concious spontaneously hypertensive rats were given intravascular stevioside 50200 mg/kg, the anesthetized rats 25398 mg/kg, and the dogs 16159 mg/kg.Results:The Stevioside reduced SBP and DBP with a dose dependent, the hypertensive duration are extend, and the effect of DBP reduced was superior to that of SBP. The doseeffect relationship was significant in the spontaneous rats received intravascular stevioside 63251 mg/kg and the dogs received 40159 mg/kg.Conclusion:Stevioside has exactly hypotensive effect, its effect of DBP reduced is superious to that of SBP reduced.
  • 药物研究
    Evaluation of Tinidazole Injection in the Prevention and Treatment of Anaerobe Infections in Female Genital Tract
    Huang Qinghua;Gong Ting;Zhang Yulan;et al.
    2000, 19(3): 207-208.
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    Objective:To evaluate the value of tinidazole (TNZ) injection in the prevention and treatment of obstetrical and gynecological patients with anaerobic infecitons in comparison with metronidazole (MNZ) injection.Method:A dose of 800 mg/200 ml TNZ or 1 000 mg/200 ml MNZ were intravenously infused daily. The gynecological patients received the treatment for 5 days, and the obstetric patients for 3 days. The isolation and culture for anaerobes were performed before and after treatment. At the same time, antibacterial activity in vitro of TNZ against 3 reference strains and 107 anaerobes isolated from patients was examined and compared with the activity of MNZ.Results:The eradication rate or obvious reduction rate of anaerobic bacteria in TNZ group and MNZ group were 91.0% and 44.0%, respectively. The total clinical effective rate of both injections were 94.0% and 82.0%, respectively. The results showed that the clinical efficacy of TNZ against anaerobes was higher than that of MNZ (P＜0.01). The both activities in vitro were confirmed also that TNZ was better than MNZ, MICs and MBCs were 0.3950.00 mg/L and 0.78100.00 mg/L, respectively.Conclusion:TNZ is more effective than MNZ in the prevention and treatment of anaerobic bacterial infection in female genital tract.
  • 药物研究
    Animal Experimental Study and Therapy Effect on ForbidFatStar Capsule
    Zhengyi;Jiang Lifu;Zhou Jinghong;et al
    2000, 19(3): 209-210.
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    Objective:The action mechanism of ForbidFatStar capsule on a reduction of blood lipid and clinical effect.Methods:Total serum cholesterol and trighlyceride of hyperlipemia in rats and blood rheology in rabbits were experimentally observed.Results:There were significiant effect for reducing the total serum cholesterol and triglyceride in human and animal, and the effect of experimental group was superior to controlled group.Conclusion:This capsule can be used for prevention and treatment of patients with hyperlipemia. The obvious toxic and side effect have not been found.
  • 药物研究
    Effect of Taurine on Serum Lipids in Rats with Nephrotic Syndrome
    Wang Xianfeng;Mai Genrong
    2000, 19(3): 211-212.
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    To confirm the effect of taurine on serum lipids in rats with nephrotic syndrome (NS).Methods:Effects of Taurine on hyperlipemia were observed by the model of doxorubicine plus NS after one side nephrotomy.Results:Taurine could significantly decreased the concentrations of total cholesterol, total triglycerides, low density lipoprotein, and very lower density lipoprotein compared with the controlled group (P＜0.05).Conclusion:Taurine has the effects of regulating lipid metabolism, and partly maintaining renal function in rats with nephrotic syndrome.
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