中国科技论文统计源期刊 中文核心期刊
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊
日本科学技术振兴机构数据库（JST）
第七届湖北十大名刊提名奖
Type 2 Diabetes mellitus is one of the most important chronic non-communicable diseases that threaten human health around the world,and its pharmacologic therapy has always been the focus of research.Chinese Diabetes Society (CDS) and American Diabetes Association (ADA) published the new guidelines in type 2 diabetes mellitus in 2017 and 2018,updated the recommendations for diagnosis and treatment of type 2 diabetes mellitus.This article reviews the update points of the treatment route and the therapeutic drugs.
Diabetes secondary to pancreatic exocrine insufficiency is commonly referred to as pancreatogenic diabetes or type 3c diabetes.Among all diabetic patients in the western population,the prevalence of type 3c diabetes is about 5%-10%,but some patients with pancreatogenic diabetes are misdiagnosed as type 2 diabetes.So far,researches on pancreatogenic diabetes are being explored.The definition,diagnosis,prevalence,pathogenesis,clinical features and treatment status of pancreatogenic diabetes are described and analyzed in this paper.
Objective To evaluate the effects of capparis spinosa total alkaloid on transforming growth factor-β(TGF-β)/Smad4 signalling pathways in systemic sclerosis (SSc). Methods A total of 90 BALB/c mice were randomly divided into normal control group,model control group,penicillamine(125 mg·kg-1) group and Capparis spinosa total alkaloid low (225 mg·kg-1),medium (450 mg·kg-1) and high (900 mg·kg-1) dose group.Except for the normal control group,SSc mouse model was established by daily subcutaneous injection of bleomycin in the back of the mice.After the establishment of the model,Capparis spinosa total alkaloid emulsifiable paste was externally applied to Capparis spinosa total alkaloid group,ground substance was externally applied to the mice in normal control group and model control groups,and penicillamine was intragastrically administrated in the penicillamine group for 60 days,once daily.After the treatment,The expression of TGF-β1 in skin tissue was detected by Western-blotting and the levels of actin / in receptor-like kinase / Smad4, nuclear factor-κB in skin tissue were measured by ELISA. Results The expression of TGF-β1 was significantly decreased after administration of 225,450 and 900 mg·kg-1 capparis spinosa total alkaloid, and the levels of ALK1 and Smad4 were significantly decreased after administration of 900 mg·kg-1 capparis spinosa total alkaloid as compared with model control group (P<0.05 or P<0.01),but the content of NF-κB was not influenced (P>0.05). Conclusion Capparis spinosa total alkaloid can accommodate abnormal expression of TGF-β1/Smad4 signalling pathways in SSc.
Objective To establish and validate the Caco-2 cell in vitro absorption model,so as to play a foundation for next study of drug absorption and transport. Methods Caco-2 cells were cultured on the polycarbonate membrane inserts fixed in the 24-well transwell transport chamber with three types cell density of low,medium and high concentration (5×104,1×105,2×105·mL-1) respectively.After being cultured for 3,6,9,12,15,18,21 d,the integrity of monolayer were assessed and compared by the cell morphology,growth characters and transepithelial electrical resistance (TEER),aiming to determine the inoculum density and culture time.Then the permeability and polarity were validated by the apical-to-basolateral amount of Lucifer Yellow across cell monolayer,the alkaline phosphatase activity in the apical side (AP),the basolateral side (BL) and intracellular activity. Results The cells of low,medium and high concentration group had fusion into a integrate cell monolayer and the maximum absorbance after being cultured for 15,12,9 d respectively.However,conglobated and dead cells were observed at the later growth stage in the medium and high concentration group and the TEER of cell monolayer were smaller than the low concentration group,which could reach 300 Ω·cm2 after cultured 15 d and keep a relatively stable value,then cells were cultured with 5×104·mL-1 cell density for 21 d.The Lucifer Yellow apparent permeability coefficient (Papp) was 3.57×10-7 cm·s-1 which was lower than 5.0×10-7 cm·s-1 according to provision.And the intracellular alkaline phosphates’ activity increased,AP/BL increased by 5 times in day 21. Conclusion The integrity,permeability and polarity of the established Caco-2 cell model in our laboratory was validated,and it can be used as an in vitro model similar with small intestinal epithelium for absorption and transport studies.
Objective To investigate the prevention effect of curcumin loaded nano-liposomes on diabetic cardiomyopathy. Methods The curcumin-loaded nano-liposomes were prepared by Film dispersion and ultrasonic hydration technology and their quality inspections were also investigated.Sixty SD rats were randomly divided into normal control group,model control group,blank and curcumin-loaded nano-liposomes group (n=15).Diabetes model was induced by intraperitoneal single injection of STZ(70 mg·kg-1).After two weeks of STZ injection,the rats with model control were used for this study.The curcumin loaded nano-liposomes treatment group rats were treated with curcumin loaded nano-liposomes(5 mg·kg-1) via caudal vein administration for 12 weeks (three times a week).Rats of normal control group,blank nano-liposomes treated group and model control group were administrated equivalent volume of 0.9% sodium chloride solution or blank nano-liposomes solution.After treatment for 12 weeks,the experimental animals underwent ultrasonic heart function examination.Then the rats were sacrificed and their hearts were arrested after saline perfusion.The myocardial cell collagen volume fraction (CVF) and apoptosis index were detected. Results Curcumin loaded nano-liposomes showed good morphology and curcumin encapsulation efficiency (88.37±1.21) %with high stability and dispersibility.From the animal experiments,the evaluation indexes in curcumin loaded nano-liposomes treated group including LVIDd and LVFS were significantly higher than model control group and nano-liposomes treated group(P<0.05),and the LVPW,CVF and apoptosis index were significantly lower than model control group and nano-liposomes treated group(P<0.05). Conclusion Curcumin loaded nano-liposomes can improve the cardiac function of diabetic rats by reducing the fibrosis and apoptosis index of myocardial cells in diabetic rats,which could be used to prevent the diabetic cardiomyopathy.
Objective To investigate the effects of metformin on myocardial fibrosis induced by isoproterenol(ISO) in rats and its mechanism. Methods A total of 48 SD male rats were randomly divided into four groups,normal control group,model control group,valsartan group and metformin group.Cardiac fibrosis models were induced in model group,Valsartan group and metformin group by subcutaneous injection of ISO 10 mg·kg-1·d-1 in the 1st day,5 mg·kg-1·d-1 in the 2nd day,3 mg·kg-1·d-1 in the 3rd-10th day.Valsartan group and metformin group were fed valsartan 10 mg·kg-1,qd or metformin 100 mg·kg-1,bid for 28 days respectively.Rats were killed at the 3rdday,the 7th day,the 14thday and the 28thday.The value of HMI,LVMI,LVW/TL were measured,and pathological alteration were observed by HE staining and Masson staining,TGF-β and Smad3 protein expression in left ventricular myocardium were detected by western blotting,and IL-6 level in serum were detected by ELISA. Results The serum levels of IL-6 in control group, model group, valsartan group and metformin group were (59.18±0.86) pg·mL-1, (71.90±1.35) pg·mL-1, (64.33±2.59) pg·mL-1 and (65.45±1.92) pg·mL-1 respectively on the 28th day.Compared with control group, the serum levels of IL-6 in model group were significantly increased(P<0.01), while their levels significantly reduced in rats received metformin (P<0.05). Conclusion Metformin may inhibit myocardial firbosis by TGF-β/Smads pathway.
Objective To systematically evaluate the efficacy and safety of ipragliflozin in reducing the body weight of patients with type 2 diabetes mellitus. Methods Cochrane Library,PubMed,Embase,Medline,CNKI,CBM,VIP and Wanfang data CBM were screened for randomized controlled trials (RCTs) of type 2 diabetes mellitus treated with ipragliflozin.After the extraction of the data from RCTs and assessing the methodological quality evaluation,the data were analyzed by RevMan5.3.5 software. Results A total of 1688 patients were enrolled in 10 RCTs in the study.Meta-analysis showed that the body mass loss [MD=-1.56,95%CI=(-1.88,-1.24),P<0.000 01],mass reduction≥5.0%[RR=2.17,95%CI=(1.42,3.32),P=0.000 3],and waist circumference reduction [MD=-1.16,95%CI=(-1.58,-0.74),P<0.000 01) were significantly better than those in the placebo group .The incidence of treatment emergent adverse events [RR=1.05,95%CI=(0.97,1.14),P=0.20] and the incidence of serious adverse events [RR=0.56,95%CI=(0.29,1.05),P=0.07] were not significant difference between ipragliflozin and placebo. Conclusion Ipragliflozin can significantly reduce the body mass of patients with type 2 diabetes mellitus,and the adverse reactions are mild.It’s necessary to pay attention to the risk of hypoglycemia when ipragliflzin is combined with insulin.
Regulation of blood lipid and anti-atherosclerosis is a hot topic in the study of poly unsaturated fatty acids in recent years.Many research showed that polyunsaturated fatty acids can inhibit atherosclerosis by reducing lipid,anti-inflammatory,anti-oxidative,inhibiting thrombosis and protecting vascular endothelial cells.Polyunsaturated fatty acids,due to their medicinal and edible homologues,have great potential drugs for regulating blood lipids and anti-atherosclerosis.
Objective To evaluate the median effective anesthetic dose of ropivacaine in ultrasound-guided transversus abdominis plane (TAP) block for analgesia in patients undergoing appendectomy. Methods Twenty-eight cases of appendectomy under general anesthesia were analyzed.After standardized general anaesthesia,a bilateral ultrasound-guided TAP block was performed on patients undergoing appendectomy using ropivacaine.Sequential method was applied.The initial dose of ropivacaine in first patient was 1.6 mg·kg-1,the dose adjustment interval was 0.2 mg·kg-1.Numerical Rating Scale was used to estimate the level of pain postoperatively.If NRS≤3,dosage of ropivacaine was decreased by 0.2 mg·kg-1.The transversus abdominis plane block analgesia duration and incidences of postoperative adverse reactions were analyzed. Results Median effective dose (ED50) of ropivacaine in ultrasound-guided transversus abdominis plane block was 2.73 mg·kg-1.95%CI (1.94,3.84) mg·kg-1. Conclusion The determination of ED50 of ropivacaine in ultrasound-guided transversus abdominis plane block improved the anesthesia efficacy and safety.
Objective To explore effect of eptazocine hydrobromide combined with sufentanil on postoperative analgesia after trans-urethral resection prostate (TURP). Methods One hundred and twenty adult patients undergoing TURP were randomly divided into three groups (n=40):eptazocine hydrobromide group (group E), dezocine combined with sufentanyl group (group DS) and eptazocine hydrobromide combined with sufentanyl group (group ES).All patients received postoperative patient controlled intravenous analgesia (PCIA).The patients in the group E were given eptazocine hydrobromide with dose of 1 mg·kg-1;group DS patients were given with dezocine of 0.3 mg·kg-1 combined with sufentanil 1.5 μg·kg-1;group ES patients were given eptazocine hydrobromide 0.2 mg·kg-1 combined with sufentanil 1.5 μg·kg-1.The VAS scores and Ramsay scores were recorded at 1 h (t1), 4 h (t2),8 h (t3), 12 h (t4), 24 h (t5) and 48 h (t6) postoperatively.Total analgesic consumption of PCIA pump and total need of remedial drugs, the incidences of postoperative dizziness, nausea and vomiting, and other adverse reactions during postoperative 48 h were also documented. Results Compared with group E, VAS scores at each time point postoperatively in group DS and group ES were lower (P<0.05);and total analgesic consumption of PCIA pump and total need of remedial drugs were also lower than group E(P<0.05);the incidence of vertigo, nausea and vomiting, dysphoria, drowsiness in group DS were higher(P<0.05);while only the incidence of nausea and vomiting in group ES was higher than group E (P<0.05).Compared with group DS, no statistical significances of VAS scores were found at each time point postoperatively between group DS and group ES (P>0.05);but total analgesic consumption of PCIA pump and the need of remedial drugs in group ES were lower (P<0.05);patients in group ES with lower incidence of respiratory depression, vertigo, dysphoria and drowsiness (P<0.05).No statistical significances were found when comparing the Ramsay scores at each time point postoperatively among three groups (P>0.05). Conclusion Eptazocine hydrobromide combined with sufentanyl can effectively alleviate the postoperative pain in patients with TURP, reduce the consumption of postoperative analgesics and incidence of analgesic related adverse reactions.
Objective To observe the clinical efficacy of Yuganlong capsule combined with entecavir in treatment of liver fibrosis in patients with chronic hepatitis B cirrhosis. Methods A total of 57 cases of patients with chronic hepatitis B cirrhosis were randomly divided into treatment group(30 cases given entecavir) and control group(27 cases treated with Yuganlong capsule combined with entecavir).Fibroscan values,hepatic fibrosis indexes(HA,LN,C-Ⅳ,PC-Ⅲ),liver function index(ALT,AST,GGT,T-BiL),and ultrasonic imaging index(inner diameters of portal vein,thickness of spleen) were detected. Results Before treatment,all indicatorshad no significant differences between the two groups(P>0.05).After 96 weeks of treatment,the Fibroscan value,HA,LN,C-Ⅳ,ALT,AST and portal vein diameter were significantly reduced in the treatment group as compared with those before treatment(all P<0.05),and there were significant differences between the treatment group and the control group after the treatment(all P<0.05). Conclusion The effect of Yuganlong capsule combined with entecavir in the treatment of chronic hepatitis B liver cirrhosis is better than that of using entecavir alone to improve liver function and liver fibrosis.
Objective To investigate the effect of ulinastatin combined pantoprazole on inflammatory factors and gastrointestinal tract in patients undergoing cardiopulmonary bypass (CBP) cardiac surgery. Methods A total of 200 patients who suffered rheumatic heart disease were scheduled for valve replacement surgery with CPB,were randomly divided into four groups:control group (CON),ulinastatin (UTI),pantoprazole groups (PTZ) and ulinastatin+pantoprazole groups(UTI+PTZ),50 cases in each group.Before CBP,group UTI was given ulinastatin 10 000 U·kg-1,group PTZ was given pantoprazole 40 mg,group UTI+PTZ was given ulinastatin 10 000 U·kg-1 and pantoprazole 40 mg,group CON was given 0.9% sodium chloride soution.The gastric mucosa pHi and blood samples would be collected in all four groups at the preoperative (t1),CPB 30 min (t2),after CBP (t3),6 h after surgery (t4),24 h (t5) five time points.The IL-6 and TNF-α would be detected by enzyme linked immunosorbent (ELISA) method,and abdominal distension,abdominal pain,hematemesis,black and defecate occult blood test positive for digestive tract related complications would be collected after the surgery 1,2 days. Results The concentration of TNF-α and IL-6 at t2,t3,t4,t5 were higher than those at t1 in all four groups(P<0.05).Compared with CON group,the concentration of TNF-α and IL-6 at t2,t3,t4,t5 in UTI,PTZ and UTI+PTZ group were significantly decreased (P<0.05).The concentration of TNF-α and IL-6 in UTI and UTI+PTZ group were better than in PTZ group.The pHi at t2,t3,t4 was lower than that at t1 in four groups(P<0.05),and pHi at t5 was obviously lower than that at t1 in group CON (P<0.05).The pHi at t2,t3,t4 in UTI,PTZ and UTI+PTZ group was higher than that in CON group(P<0.05),and pHi in UTI+PTZ group was better than that in UTI and PTZ group.The postoperative gastrointestinal complications in CON group were higher than those in UTI,PTZ and UTI+PTZ group (P<0.05). Conclusion Ulinastatin combined with pantoprazole for patients undergoing CPB heart surgery,can significantly reduce the release of TNF-α and IL-6、increase gastric pHi and reduce the incidence of gastrointestinal complications.
Due to the differences of background,ways of thinking,visual angle and research tools between Chinese medicine and Western medicine,most Chinese medicine research based on western medicine are of low clinical value,although the combination of the Western and Traditional Chinese Medicine has gaining popularity.It is possible to change our perspective and use Chinese medicine theory to think and guide all modern treatment methods.This theory which is explained in the Tumor Green Therapeutics,has achieved remarkable clinical results and gained rapid development.Syndrome differentiation and treatment is the essence of TCM.Eight principles of syndrome differentiation of TCM are the general principles.The principles of cold and heat syndrome differentiation are the basis for the complex syndrome types.Therefore, this article will be a preliminary study for anti-cancer medicine from point of view of the principles of cold and heat syndrome differentiation, and will provide more clinical reference.
Picris L.are annual,biennial to perennial herbs of Compositae.They are distributed in Europe,Asia and North Africa,and there are 5 species in China.The chemical composition mainly contains flavonoids,organic acids,terpenoids,and polysaccharides.The actions were antipyretic,antidotal,antiphlogistic and analgesic.So was commonly used in the treatment of some diseases such as mastitis,mumps and hepatitis in civil.In contemporary research,hypoglycemic,hypolipidemic and anti-inflammatory,antioxidant and other physiological activities were found.In addition,Its super collection capacity of metal ions like Zn,Cd,Pb and etc may be used for the recovery of heavy metal contaminated soil and environmental protection.
Objective To establish a method for the determination of nigeglanoside in seeds of Nigella glandulifera. Methods The content of nigeglanoside was determined by HPLC.The separation was performed on a C18 column (YMC-Pack ODS-A,250 mm×4.6 mm,5 μm) with a gradient elution system of acetonitrile and 0.017 5 mol·L-1 acetic acid solution at the flow rate of 1.0 mL·min-1.The detection wavelength was set at 290 nm,and column temperature was 30 ℃. Results The linear range of nigeglanoside was 0.01-0.30 mg·mL-1 (R2=0.9991).The RSDs of precision,stability and repeatability were all less than 2%.The average recovery was 96.66% (RSD=1.25%,n=6). Conclusion The method is accurate and reproducible.It is effective in controlling the quality of seeds of Nigella glandulifera .
Objective To establish a method for the determination of residual solvents in tulobuterol by GC and optimize the purified process of crude tulobuterol product by this method. Methods The analysis was performed on Agilent DB-624 capillary column (30 m×0.32 mm,1.8 μm).The carrier gas was nitrogen at 1 mL·min-1.The injector temperature was 250 ℃.Detector was FID with hydrogen at 45 mL·min-1 and air at 450 mL·min-1.The detector temperature was 250 ℃.The column temperature program was used.And the flow ratio was 10:1.Dimethyl sulfoxide (DMSO) was used as solvent of reference and test solution. Results Ethanol,tert-butylamine,dichloromethane,tert-butyl-methyl ether,n-hexane and 1,4-dioxane were completely separated.The calibration curve of each solvent showed good linear correlation.The RSD of precision was less than 5.0% and the average recovery ranged from 97.0% to 104.0% (RSD<5%).By optimizing the purification process of toloterol,the residue of organic solvent in the preparation of tolobuterol was in accordance with the Chinese Pharmacopoeia (2015)limit. Conclusion Validated by methodology,this simple,rapid and precise method can be used for the test of residual solvents in tulobuterol.
Objective To prepare loratadine nanoparticle suspension and investigate the stability of it. Methods Loratadine nanoparticle suspension was prepared by anti-tumor agent precipitation method,the nanosuspension was characterized by particle size analyzer and transmission electron microscopy,the optimal prescription was screened,and the stability of nanosuspension was investigated by HPLC. Results The optimal prescription stablizer was SDS and organic phase was ethanol.The drug loading radio was 1:2 and the proportion of organic phase to water was 5:10 and the time of high shear was 5 min.Loratadine suspension was pale blue with a uniform emulsion.The nanoparticles were spherical,with an average particle size of 112.8 nm,the PDI of 0.095 and the Zeta potential of -38.6 mV.The suspension had the best physical and chemical stability at room temperature. Conclusion The preparation method of loratadine suspension with good stability is simple,and it’s expected to become the new nano-drug delivery system of loratadine.
Objective To establish fingerprint of volatile components in golden throat lozenges by GC-MS. Methods Volatile components from 10 batches of golden throat lozenges were extracted by steam distillation method and analyzed by GC-MS with n-tetradecane as internal standard.Fingerprint peak detection and similarity evaluation were applied to the total ion chromatogram(TIC)of GC-MS by “Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine (Version 2004)” ,fingerprint peak was identified by mass spectrometry. Results A GC-MS fingerprint was established based on 10 common peaks as characteristic fingerprint information.The similarity of fingerprint peaks from the 10 batches of samples were more than 0.998.Ten fingerprint peaks were determined by mass spectrometry, all of which were composed of monoterpenes and monoterpenes containing oxygen, the highest content of which was L-menthol containing oxygen monoterpenes, accounting for 83.17% of the total. Conclusion The fingerprint established by gas chromatography-mass spectrometry can completely reflect the volatile components of golden throat lozenges tablets, with strong characteristics and specificity, and can be used as an effective method for the quality control of volatile components inf golden throat lozenges.
Objective To establish a method that could detect 5 components of Fufang Heishen oral liquid simultaneously. Methods The component was performed by high performance liquid chromatography (HPLC) equipped with Agilent Hypersil ODS (4.6 mm×250 mm,5 μm).The mobile phase consisted of acetonitrile-0.1% Phosphoric acid with gradient elution.The flow rate was 1.0 mL·min-1 with the 210 nm and 270 nm detection wavelength,20 μL injection volume and 30 ℃ column temperature. Results A good linear relationship was observed with the range of 7.12-85.44 mg·L-1 for Harpagide(r=0.999 9),2.50-30.00 mg·L-1 for Harpagoside(r=0.999 8),25.35-304.20 mg·L-1 for Cinnamic acid(r=0.999 7),0.73-8.70 mg·L-1 for Tectoridin(r=0.999 7)and 1.20-14.40 mg·L-1 for Irisflorentin(r=0.999 8).The average recovery of each detected component of Fufang Heishen Oral Liquid was 98.8%,102.7%,98.8%,99.3%,99.9% the RSD were 1.23%,2.89%,2.60%,1.44%,2.84%(n=6). Conclusion The method is simple,rapid and accurate and can be used to detect the content of Harpagide,Harpagoside,Cinnamic acid,Tectoridin and Irisflorentin of Fufang Heishen Oral Liquid.
Objective To establish the chromatographic conditions of isochlorogenic acid A and isochlorogenic acid C in vernonia anthelmintica. Methods By changing the mobile phase,flow rate,column temperature and other chromatographic conditions,the best chromatographic conditions was we pursued to established. Results The linear relationship between the concentration of isochlorogenic acid A and the peak area was between 5.825-69.9 μg·mL-1,and the concentration of isochlorogenic acid C,was between 5.15-61.80 μg·mL-1 and the peak area was good .The sample recovery rates of the two groups were 98.70%-101.92%(RSD=1.04%,n=9)、95.99%-102.52%(RSD=1.90%,n=9). Conclusion The method is simple,rapid,accurate and reliable for the determination of isochlorogenic acid A and isochlorogenic acid C in Vernonia anthelmintica and also for the quality control of the raw material.
Objective The quality evaluation of the Shuwei mixture was determined by the content of the six components of sinapine cyanide sulfonate,magnolol,honokiol,hesperidin,naringin and neohesperidin. Methods RP-HPLC method was used.The separation was performed on a Agilent ZORBAX Eclispse SB-C18 column (4.6 mm×250 mm,5 mm),the mobile phase consisted of acetonitrile(A)-0.1% phosphoric acid with gradient elution at the flow rate of 1.0 mL·min-1.The detection wavelength was 326 nm(sinapine cyanide sulfonate),294 nm(magnolol, honokiol)and 283 nm(naringin, neohesperidin).The column temperature was kept at 30 ℃. Results The sinapine cyanide sulfonate,magnolol,honokiol,hesperidin,naringin and neohesperidin all had good linear relationship in the ranges of 0.049 6-1.24,0.048 2-1.205,0.060 5-1.512 5,0.187 2-4.68,0.131 6-3.29,0.197-4.925 μg.The average recoveries were 100.66%, 99.86%, 101.37%, 102.41%, 99.01%, 102.05%, respectively, RSD were 0.82%, 1.89%, 2.56 %, 0.74%, 1.54%, 0.99%, respectively. Conclusion The method is simple,accurate,reproducible and nice to the separation,and can be used for the quality evaluation of Shuwei mixture.
Objective To establish a method for the dissolution determination of ambroxol hydrochloride orally disinegreting tablets. Methods The UV spectrophotometry was used.The detecting wavelength was at 244 nm.The liquid of dissolution was hydrochloride(0.1 mol·L -1).Rotational speed was 50 r·min-1. Results The linearity range was 3.16-28.44 μg·mL-1.The regression equation was Y=0.024 2X+0.018 3(r=0.999 3).The RSD of repeatable test was 0.28%.The average recovery of methodology was 100.4% and RSD was 0.77%. Conclusion The method is simple and reliable, and can be used for the dissolution determination of ambroxol hydrochloride orally disinegreting tablets.
Objective To evaluate the protective effect of ACEI drugs on radiation pneumonitis,and to compare ACEI with ARB,statin,steroid,and NSAID on the treatment of radiation induced lung injury through the network Meta-analysis. Methods A computer-based online search of PubMed,EMbase,Cochrane Library,as well as CNKI,CBM,VIP,Wanfang database was conduce.The NOS score was used to evaluate the quality of studies,and the results were analyzed by stata14.0 software. Results ACEI drugs showed desired effect on the treatment of radiation pneumonia,which can effectively reduce the incidence of radiation-induced lung injury,but can not prolong the survival time of the patients.The protective effects of statins and non-steroid anti-inflammatory drugs are second only to those of ACEI.Meta-analysis results were proved to be stable and credible by the sensitive-analysis.The therapeutic effect of ACEI on radiation induced lung injury is not affected by sex and age of patients. Conclusion ACEI drugs have an optimum protective effect on radiation induced lung injury.
Objective A case would be discussed on suspected demyelination due to electrolyte disturbance to provide references for clinical pharmacists to carry out pharmaceutical care. Methods A pharmaceutical care case on PCI postoperative acute heart failure and contrast induced nephropathy with suspected demyelization due to electrolyte disturbance was introduced through a combination of analysis on clinical symptoms,renal function,electrolyte,blood glucose level and further discussion on consciousness change reason,diuretic use,electrolyte management,and other related issues. Results Clinical pharmacist should provide more care to patients with abnormal blood sodium and osmotic pressure,pay more attention to the calculation and evaluation of rehydration sodium/filling quantity and speed,accumulate more knowledge of contrast induced nephropathy,and raise their awareness on the identification of high risk population. Conclusion Arrhythmia,heart failure,renal failure,infection can beincentives to one another,and thus doctors and pharmacists must pay more attention to the comprehensive situations.
According to the quality requirements of clinical trials and the work characteristics and the development trend of clinical research coordinators (CRCs),we proposed that converting non-hospital CRCs to hospital CRCs or ‘hospital Staffs’ and arranging them to assist quality management in clinical trials are very important and significant for improving the quality of clinical trials.In present study,we also analyzed the methods about how to convert non-hospital clinical research coordinators to hospital CRC and briefly described their role in quality management.
