醋酸乌利司他优势药用晶型研究

杨雪薇,徐娟,宁丽峰,张丽,杨德智,王慧萍,杜冠华,吕凌,吕扬

Research on Preponderant Pharmaceutical Polymorphs of the Contraceptive Drug Ulipristal Acetate

Xuewei YANG,Juan XU,Lifeng NING,Li ZHANG,Dezhi YANG,Huiping WANG,Guanhua DU,Ling LYU,Yang LYU

醋酸乌利司他5种不含溶剂晶型溶解性曲线 A.0.1 mol·L-1盐酸溶液(pH值=1.2);B.醋酸盐缓冲液(pH值=4.5);C.磷酸盐缓冲液(pH值=6.8);D.水(pH值=7.0);E. 0.2%SDS溶液(pH值=7.0);F. 0.5%SDS溶液(pH值=7.3)

Solubility curves of five non-solvate forms of ulipristal acetate A.0.1 mol·L-1 hydrochloric acid solution (pH=1.2);B.acetate buffer (pH=4.5);C.phosphate buffer (pH=6.8);D.water (pH=7.0);E.0.2% SDS solution (pH=7.0);F. 0.5% SDS solution (pH=7.3)