甲硝唑有关物质测定及杂质谱研究

向东, 杨志勇, 何建武, 施春阳, 方建国, 王文清

Determination and Impurity Profile of Related Substances of Metronidazole by HPLC

Dong XIANG, Zhiyong YANG, Jianwu HE, Chunyang SHI, Jianguo FANG, Wenqing WANG

方法专属性考察色谱图 a. undestroyed; b. destroyed by acid; c. destroyed by intense light; d. destroyed by excessive heating; e. destroyed by oxidation; f. destroyed by alkali; 1. metronidazole; 2. unknown impurity 1; 3. unknown impurity 2; 4. impurity A; 5. impurity D; 6. impurity F

HPLC chromatograms of the specificity test