Objective To observe the effect of isatin on prostatic hyperplasia in model mice. Methods Sixty male mice were divided into six groups (n=10): normal control group(0.9% sodium chloride solution 0.2 mL·d-1,ig), model control group(testosterone propionate 5 mg·kg-1 hypodermic injection for modeling), Qianliekang group(Qianliekang 5 mg·kg-1,ig when modeling), isatin low-dose group(isatin 25 mg·kg-1,ig when modeling), isatin medial-dose group(isatin 50 mg·kg-1,ig when modeling),isatin high-dose group(isatin 100 mg·kg-1,ig when modeling). It was given once a day for 15 consecutive days . The prostate weight and prostate index were measured, and HE staining was observed. Results The prostate indexs of mice in low-,medial- and high-dose of isatin group were (61.04±0.96), (52.53±1.71) and (43.78±2.08),respectively, which were lower than in the model group (76.23±2.47) (P<0.05). Moreover, epithelial hyperplasia was inhibited. Conclusion Isatin could inhibit the prostatic hyperplasia of mice which was induced by testosterone propionate.
GIL-TURNES MS,HAY ME,FENICALW.Symbiotic ma-rine bacteria chemically defend crustacean embryos from a pathogenic fungus[J].,1989,246(4926):116-118.
Embryos of the shrimp Palaemon macrodactylus are remarkably resistant to infection by the fungus Lagenidium callinectes, a recognized pathogen of many crustaceans. An Alteromonas sp. bacterial strain consistently isolated from the surface of the embryos, produces 2,3-indolinedione (isatin), a compound that inhibits the pathogenic fungus. If exposed to the fungus, bacteria-free embryos quickly die, whereas similar embryos reinoculated with the bacteria or treated only with 2,3-indolinedione live well. The commensal Alteromonas sp. bacteria protect shrimp embryos from fungal infection by producing and liberating the antifungal metabolite 2,3-indolinedione.
WATKINSP,CLOWA,GLOVERV,et al.Isatin,regional distribution in rat brain and tissues[J].,1990,17(2):321-323.
Isatin has recently been identified in rat tissues and normal human urine, where it forms the major proportion of the endogenous monoamine oxidase inhibitor, tribulin. In this paper, we show that isatin, measured by gas chromatography/mass spectrometry, has a distinct regional distribution in rat tissues, with highest concentrations in seminal vesicles (1.6 ?g/g) and vas deferens (3.4 ?g/g). There was also a discontinuous distribution within rat brain, concentrations being highest in the hippocampus (0.13 ?g/g).