蝙蝠葛苏林碱对转染人胚肾细胞T型钙通道亚型(CaV3.1)电生理特性的作用

余玲,丁杰,郭莲军

Effects of Daurisoline on Electrophysiological Characteristics of T-type Calclium Channel Ca_V3.1 in Transfected Human Embryonic Kidney Cells

Ling YU,Jie DING,Lianjun GUO

图1 在不同钳制电位下DS对人胚肾细胞表达Ca_V3.1电流的抑制作用(xˉ±s,n=6)
A.钳制电位为-110 mV下的原始电流图; B.钳制电位为-70 mV下的原始电流图;C.-110 mV钳制电位下1,3 和10 μmol·L^-1DS对ICaV3.1抑制百分率;D.-70 mV钳制电位下1,3 和 10 μmol·L^-1DS对ICaV3.1抑制百分率;与1 μmol·L^-1DS比较,^*1P<0.05,^*2P<0.01

Fig.1 Inhibitory effects of DS on Ca_V3.1 in human embryonic kidney cells at different holding potentials(xˉ±s,n=6)
A.Original current diagram of holding potentials at-110 mV;B. Original current diagram of holding potentials at-70 mV;C. Percentage of I_Cav3.1. inhibition by 1,3,10 μmol·L^-1 DS at holding potential of -110 mV;D . Percentage of I_Cav3.1. inhibition by 1,3,10 μmol·L^-1 DS at holding potential of -70 mV;Compared with 1 μmol·L^-1 DS,^*1P<0.05,^*2P<0.01