蝙蝠葛苏林碱对转染人胚肾细胞T型钙通道亚型(CaV3.1)电生理特性的作用

余玲,丁杰,郭莲军

Effects of Daurisoline on Electrophysiological Characteristics of T-type Calclium Channel CaV3.1 in Transfected Human Embryonic Kidney Cells

Ling YU,Jie DING,Lianjun GUO

图3 在不同钳制电位下DS对人胚肾细胞T型钙通道CaV3.1失活过程的影响 A.钳制电位为-110 mV时,DS对T型钙通道CaV3.1失活的电流图;B.根据图A得出的DS作用的失活常数(tinact)与时间的关系统计图;C.钳制电位为-70 mV时,DS对T型钙通道CaV3.1失活的电流图; D.根据图C所得的DS作用的失活常数(tinact)与时间的关系统计图

Fig.3 Inacitivation kinetics of CaV3.1 channel in human embryonic kidney cells by DS at different holding potentials A.ICaV3.1 representative current traces in the presence of DS at holding potentials of -110 mV;B. Curve of tinact of DS versus time according figure A;C.ICav3.1. representative current traces in the presence of DS at holding potentials of -70 mV;D. Curve of tinact of DS versus time accrording figure C