芍药苷调控酸敏感离子通道发挥镇痛作用*

熊哲,谢家璇,朱鲲博,张雅婷,杨荣

Anti-nociceptive Effects of Paeoniflorin in Formalin-induced Pain by Regulating Acid-Sensing Ion Channels

Zhe XIONG,Jiaxuan XIE,Kunbo ZHU,Yating ZHANG,Rong YANG

图1 芍药苷和阿米洛利对大鼠TG神经元ASICs电流的抑制作用 芍药苷(100 μmol·L-1)和阿米洛利(100 μmol·L-1)对酸性外液(pH 5.9)诱发的缓慢失活型(A) 、快速失活型(B)和双内向电流(C)抑制作用。

Fig.1 Inhibition of Pae and amiloride on ASICs current in TG neurons of Rats Representative slow inactivated current type (A), fast inactivated current type(B) and biphasic inward current type(C) activated by acid extracellular solution (pH 5.9) were inhibited by Pae (100 μmol·L-1) and amiloride (100 μmol·L-1).