芍药苷调控酸敏感离子通道发挥镇痛作用*

熊哲,谢家璇,朱鲲博,张雅婷,杨荣

Anti-nociceptive Effects of Paeoniflorin in Formalin-induced Pain by Regulating Acid-Sensing Ion Channels

Zhe XIONG,Jiaxuan XIE,Kunbo ZHU,Yating ZHANG,Rong YANG

图2 芍药苷浓度依赖性抑制大鼠TG神经元Iasic A.不同浓度芍药苷(10~1000 μmol·L-1)抑制Iasic(pH值5.9)的典型电流图;B.芍药苷对Iasic(pH值5.9)的抑制作用有浓度依赖性。

Fig.2 Concentration-dependent inhibition of Pae on Iasic in TG neurons of Rats A.Representative current of Iasic (pH 5.9 ) inhibited with different concentration of Pae(10~1000 μmol·L-1); B.concentration-dependent inhibition of Pae on Iasic(pH 5.9).