芍药苷调控酸敏感离子通道发挥镇痛作用*

熊哲,谢家璇,朱鲲博,张雅婷,杨荣

Anti-nociceptive Effects of Paeoniflorin in Formalin-induced Pain by Regulating Acid-Sensing Ion Channels

Zhe XIONG,Jiaxuan XIE,Kunbo ZHU,Yating ZHANG,Rong YANG

图3 芍药苷对Iasic量效曲线的影响 A.芍药苷(100 μmol·L-1) 抑制不同pH值酸性外液诱导的Iasic;B.预加100 μmol·L-1芍药苷后,Iacid量效曲线明显下移。

Fig.3 Effect of Pae on Dose-response curve of Iasic A.Current traces showed that Pae(100 μmol·L-1) inhibited Iasic induced by different pH acid extracellular solution; B.The Concentration-response curve of Iasic with Pae(100 μmol·L-1) pretreatment shifted downwards significantly.