芍药苷调控酸敏感离子通道发挥镇痛作用*

熊哲,谢家璇,朱鲲博,张雅婷,杨荣

Anti-nociceptive Effects of Paeoniflorin in Formalin-induced Pain by Regulating Acid-Sensing Ion Channels

Zhe XIONG,Jiaxuan XIE,Kunbo ZHU,Yating ZHANG,Rong YANG

图4 芍药苷抑制 Iasic与腺苷A1受体关系 A.腺苷A1受体拮抗剂DPCPX阻断了芍药苷抑制Iacid(pH=5.9)的典型电流图;B.联合应用DPCPX(1 μmol·L-1)阻断了芍药苷(100 μmol·L-1)对Iacid(pH=5.9)抑制作用;与芍药苷组比较,*1P<0.01。

Fig.4 Relationship of the inhibition of Pae on Iasic and adenosine A1 antagonist A.Adenosine A1 antagonist (DPCPX) abrogated the inhibition of Pae on Iasic (pH=5.9) ; B.DPCPX combination abrogated the inhibition of Pae(100 μmol·L-1) on Iasic (pH=5.9); *1P<0.01 versus Pae.