芍药苷调控酸敏感离子通道发挥镇痛作用*

熊哲,谢家璇,朱鲲博,张雅婷,杨荣

Anti-nociceptive Effects of Paeoniflorin in Formalin-induced Pain by Regulating Acid-Sensing Ion Channels

Zhe XIONG,Jiaxuan XIE,Kunbo ZHU,Yating ZHANG,Rong YANG

图5 芍药苷抗伤害性作用与腺苷A1受体关系 A.阿米洛利对Formalin诱发疼痛反应的抑制作用;B.Pae的面部镇痛作用;与模型对照组比较,*1P<0.01,*4P<0.05;与对照组比较,*2P<0.01,*3P<0.05;与芍药苷组比较, *5P<0.05。

Fig.5 Relationship of anti-nociceptive response of Pae and adenosine A1 antagonist A.amiloride attenuated formalin-induced pain response;B.analgesic effect of Pae on face;Compared with model group,*1P<0.01,*4P<0.05;Compared with control group,*2P<0.01,*3P<0.05;Compared with Pae group, *5P<0.05.