超高效液相色谱法同时测定复方丹参方中4种成分及其在大鼠体内药动学研究*

贾田芊,黄喆,崔春利,李兴欢,任丽,唐志书,史亚军,孙静

Pharmacokinetics of Four Components of Compound Danshen Extracts in Rat by UPLC Method

Tianqian JIA,Zhe HUANG,Chunli CUI,Xinghuan LI,Li REN,Zhishu TANG,Yajun SHI,Jing SUN

图1 大鼠血浆HPLC色谱图 A.混合标准品;B.空白血浆;C.空白血浆加混合对照品;D.给药后45 min血浆样品;1.丹酚酸B;2.三七皂苷R1;3.人参皂苷Rg1;4.丹参酮ⅡA

Fig.1 HPLC chromatogram of plasma sample from rats A. mixed standard; B. blank plasma; C. blank plasma spiked with mixed standard; D. plasma sample from a patient 45 min after medication;1.salvianolic acid B;2.notoginsenoside R1;3.ginsenoside Rgl;4.tanshinone ⅡA