超高效液相色谱法同时测定复方丹参方中4种成分及其在大鼠体内药动学研究*

贾田芊,黄喆,崔春利,李兴欢,任丽,唐志书,史亚军,孙静

Pharmacokinetics of Four Components of Compound Danshen Extracts in Rat by UPLC Method

Tianqian JIA,Zhe HUANG,Chunli CUI,Xinghuan LI,Li REN,Zhishu TANG,Yajun SHI,Jing SUN

图2 大鼠灌胃给予复方丹参方后三七皂苷R1 (A)、人参皂苷Rg1 (B)、丹酚酸B (C)、丹参酮ⅡA(D)在血浆中药物浓度-时间曲线(n=5)

Fig.2 Mean plasma concentration-time profile of notoginsenoside R1 (A)、ginsenoside Rg1 (B)、salvianolic acid B (C) and tanshinoneⅡA(D) in rat plasma after oral administration of compound Danshen preparation(n=5)