中国科技论文统计源期刊 中文核心期刊  
美国《化学文摘》《国际药学文摘》
《乌利希期刊指南》
WHO《西太平洋地区医学索引》来源期刊  
日本科学技术振兴机构数据库(JST)
第七届湖北十大名刊提名奖  
医药导报, 2019, 38(3): 333-336
doi: 10.3870/j.issn.1004-0781.2019.03.010
药师主导的干预对哮喘和COPD患者掌握吸入技术的影响*
Effect of Pharmacist-led Intervention on Mastery of Inhalation Technique for Patients
吴秋惠, 张桂凡, 张晶晶, 葛卫红

摘要:

目的 调查药师主导的干预对哮喘和慢性阻塞性肺疾病(COPD)患者掌握吸入技术的的影响。方法 药师采用吸入技术评估表格对患者吸入技术进行评估,比较药师干预前后患者对吸入技术的掌握情况,了解药师对患者吸入技术的干预效果。结果 经药师干预后,患者对不同装置使用错误的条目数显著降低。都保装置(信必可都保)由干预前人均错误3.22条降为0.65条,干粉装置(噻托溴铵)由人均错误3.20条下降为0.56条,均差异有统计学意义。结论 哮喘和COPD患者对吸入技术掌握情况较差,药师干预对患者正确掌握吸入装置使用有明显效果,药师主导的吸入技术评估教育对哮喘和COPD患者有必要。

关键词: 哮喘 ; 肺疾病 ; 阻塞性 ; 慢性 ; 药师 ; 吸入技术

Abstract:

Objective To investigate the influence of pharmacist-led intervention on the mastery of inhalation techniques for patients with asthma/COPD. Methods The inhalation technique assessment form was used to assess the patient mastery of inhalation technique.The patient mastery of inhalation technique after the pharmacist’s face to face intervention was compared to find the effect of pharmacist intervention on inhalation techniques. Results With pharmacist intervention, the frequency of patient making mistakes in using different devices was significantly decreased.The frequency of making mistakes in using Symbicort Turbuhaler and HandiHaler for each patient decreased from 3.22 to 0.65, and from 3.20 to 0.56, respectively. Conclusion The patients with asthma and COPD poorly mastered inhalation technique.Pharmacists intervention has definite effect on the correct use of inhalation device.It is necessary for pharmacists to evaluate the mastery of inhalation technique for patients with asthma/COPD.

Key words: Asthma ; Pulmonary disease ; obstructive ; chronic ; Pharmacist ; Inhalation technique

慢性呼吸系统疾病如哮喘和慢性阻塞性肺疾病(chronic obstructive phlmonary disease,COPD)是威胁大众健康的常见慢性病,尽管有效的药物和循证指南已有很大发展,但发病率和病死率并无重大变化。研究表明,大多数哮喘和COPD患者疾病控制不佳的原因之一是患者无法正确使用吸入装置[1]

吸入药物治疗是目前治疗哮喘和COPD的重要方式,该疗法的主要优点是药物直接输送到气道,达到较高的局部浓度,显著减少全身不良反应风险。吸入药物在呼吸道中的沉积模式取决于装置、药物配方和患者吸入技术等多个因素[2]。吸入装置的使用涉及一系列复杂的步骤,需要正确掌握,错误使用吸入装置可导致疾病控制不佳、可避免的不良反应,也可能导致更高的治疗费用。有研究表明,50%~80%哮喘和COPD患者未能正确使用吸入装置[3]。FINK等[4]研究显示,在美国由于吸入药物的错误使用导致的浪费每年5百万~7百万美元。

有关哮喘和COPD的全球及中国指南均指出,应定期评估患者吸入技术,并对其错误的操作进行纠正。尽管目前国内有诸多文献提及吸入装置教育的重要性,也有部分药师参与患者的吸入剂教育,并取得了积极的效果,但这类研究尚未涉及具体吸入技术评估要点,进一步的研究需要探索患者教育的有效性和频率,并考虑具体的干预措施,以提高吸入技术水平[5]。2017年4—7月,笔者采用自制吸入装置评估表格,调查患者吸入技术掌握情况,并通过标准化程序明确药师单次干预前后的效果,现报道如下。

1 资料与方法
1.1 临床资料

收集在我院呼吸科门诊治疗的支气管哮喘及COPD患者,共 112 例,均符合中华医学会呼吸分会制定的相关疾病诊断标准[6,7]。其中使用布地奈德/福莫特罗粉(商品名:信必可都保,每吸160 μg/4.5 μg,进口药品注册证号H20140458)吸入剂72例,用法用量为1吸,bid或2吸,bid;使用噻托溴铵粉(商品名:思力华,每粒18 μg,进口药品注册标准JX20080017)吸入剂40例,用法用量为1吸,qd。记录患者基本信息,包括姓名、性别、年龄、体质量指数(BMI)、吸烟情况、受教育程度、并发症及最近一年急性加重情况等,见表1。

表1 患者一般资料
Tab.1 Basic characteristics of the patients 例, $\bar{x}$±s,n=112
吸入剂 年龄/
BMI/
[kg·(m2)-1]
吸烟情况 受教育程度 并发症 过去一年急性加重
% 吸烟 不吸烟 大学及以上 高中 初中 小学 文盲 高血压 糖尿病 冠心病 急诊/输液 住院
信必可都保 56±15 27 37.5 23.5±3.7 2 70 18 19 15 13 7 20 8 1 30 10
噻托溴铵 67±9 33 82.5 22.6±3.3 8 32 5 6 15 12 2 8 1 1 9 4

表1 患者一般资料

Tab.1 Basic characteristics of the patients 例, $\bar{x}$±s,n=112

1.2 研究方法

本研究为前瞻性干预研究,药师对使用吸入剂的患者进行一次面对面的吸入技术指导。为评估干预效果,比较干预前后患者吸入技术掌握情况。药师指导后1个月进行电话随访,并进行吸入技术二次评估,通过对比患者两次吸入技术掌握情况,了解药师对吸入技术的干预的效果、患者的接受情况以及疾病症状改善情况。

1.3 吸入技术评估流程

药师登陆门诊医生工作站,扫描患者ID号,告知患者用药剂量及相关注意事项,同时按照吸入剂标准操作流程使用练习器对患者进行一次面对面的吸入操作演示,演示结束后要求患者根据学习内容进行操作。为评估患者吸入技术,药师通过查阅文献,结合工作经验,制定各装置的操作步骤清单,患者在执行吸入操作的过程中,由药师按照事先制定的吸入技术评估表格进行操作要点打分记录,每一个步骤都被记录操作是否正确,患者操作完成后,由药师纠正错误,登记相关信息,并告知下次电话随访时间。

1.3.1 实施标准用药教育流程 ①练习器操作教育(对于首次用药或已经使用过该类制剂而未接受过用药教育者,均采用练习器进行用药教育)。为患者发放该吸入剂用药指导书面材料,为患者介绍该制剂、注意事项说明(包括数字指示窗口)、剂量杆或剂量旋钮到位、吸入时的体位和呼气准备;吸入药物;憋气;漱口;贮存等流程。②药师演示用药流程(告之三“气”,即“呼气”“吸气”“憋气”,重点强调吸药前呼气准备工作,以及吸药后的憋气)。③由患者演示用药流程。药师演示完毕后,将练习器交给患者,患者在药师监督下完成整个吸入剂操作流程,在用药过程中,药师依据患者操作情况及时记录,鼓励患者,同时告知其在用药中存在的问题,督促患者掌握用药技巧。④告知患者用药注意事项。告知患者在吸入结束后记得用温水漱口,并将漱口水吐出,以减少口腔和咽喉药物沉积,减少声音嘶哑、口咽念珠菌感染等局部不良反应,并告之患者坚持用药的重要性。⑤建立患者用药教育记录表。对于接受标准用药教育的患者,药师均会建立相应的记录表,包括患者姓名、年龄、门诊ID号、诊断、用药内容及备注等[8]

1.4 效果观察

1个月后,药师电话随访患者,并进行第二次吸入技术评估,记录患者吸入技术掌握情况,告知患者坚持用药的重要性,解决患者用药过程中的相关疑问。

1.5 统计学方法

采用 SPSS20.0版软件进行统计学分析,以P<0.05为差异有统计学意义。

2 结果

患者两次吸入技术评估详情见表2。对比两次评估的吸入操作技术条目数,不同装置对应不同的吸入技术评估表格。信必可都保用药教育前后数据符合正态分布,采用两配对样本t检验,P=0.000<0.05,差异有统计学意义;噻托溴铵粉用药教育前后数据不符合正态分布,采用非参数检验,笔者在本文采用Wilcoxon秩和检验,P=0.000<0.05,差异有统计学意义。研究结果显示,对于不同装置,患者经药师面对面评估教育后,发生错误的条目数显著降低,信必可都保由教育前人均错误3.22条下降为0.65条,噻托溴铵由人均错误3.20条下降为0.56条,均差异有统计学意义。患者症状控制率80.3%,说明药师面对面吸入技术评估对患者正确掌握吸入装置使用有明确效果,药师主导的吸入技术评估教育对哮喘和COPD患者必要。

表2 患者未正确使用吸入药物清单
Tab.2 Checklist of incorrect use of inhalation medication by the patients
吸入剂类型 编号 吸入错误操作 发生频次/次 发生频率/% P
首次评估 二次评估 首次评估 二次评估
信必可都保 E1 未检查剂量知识窗和有效期 6 0 9.8 0.0 0.000
E2 未正确旋转按钮并上药 10 0 16.4 0.0
E3 转动按钮时,未保持瓶身直立 29 0 47.5 0.0
E4 吸入药物之前,未缓慢呼气 13 1 21.3 1.6
E5 缓慢呼气时,未避开吸嘴 17 0 27.9 0.0
E6 未将吸嘴置于上下齿间,并用嘴唇包裹严实 14 1 23.0 1.6
E7 未用力且深长地吸气 36 10 59.0 16.4
E8 吸气时,未保持气流平稳连续 16 3 26.2 4.9
E9 吸气时,未做到鼻子不吸气 6 0 9.8 0.0
E10 吸气时,未做到不往吸嘴回气 5 0 8.2 0.0
E11 吸气结束后,未做到从口中撤离装置并屏气5 s 11 0 18.0 0.0
E12 屏气后,未做到缓慢呼气 0 0 0.0 0.0
E13 在需要第二吸药甚至更多时,未重复以上步骤 5 0 8.2 0.0
E14 吸药结束后,未用卫生纸擦拭吸嘴 18 3 29.5 4.9
E15 吸药结束后,未做到避免再次转动旋钮 8 0 13.1 0.0
E16 未将防尘帽盖好 1 0 1.6 0.0
E17 未漱口2或3次 7 16 11.5 26.2
E18 未吐掉漱口水 7 5 11.5 8.2
E19 不清楚“吸入后感觉不到药物属于正常现象” 16 3 26.2 4.9
E20 不清楚“如何判断药物已使用完” 7 5 11.5 8.2
合计 232 47 - -
噻托溴铵 E1 未检查药品有效期 5 0 17.2 0.0 0.000
E2 未做到每次取用胶囊时仅暴露1粒 2 0 6.9 0.0
E3 未将胶囊放入中央室 5 0 17.2 0.0
E4 针刺打孔前未将吸嘴盖紧 1 0 3.4 0.0
E5 在合上吸嘴后,未用针刺按钮打孔 5 0 17.2 0.0
E6 吸入药物之前,未缓慢呼气 14 1 48.3 3.4
E7 缓慢呼气时,未避开吸嘴 15 0 51.7 0.0
E8 未将吸嘴置于上下齿间,并用嘴唇包裹严实 3 0 10.3 0.0
E9 未用力且深长地吸气 14 2 48.3 6.9
E10 吸气时,未保持气流平稳连续 8 0 27.6 0.0
E11 吸气时,未做到鼻子不吸气 2 0 6.9 0.0
E12 吸气时,未做到不往吸嘴回气 6 0 20.7 0.0
E13 吸气结束时,未做到从口中撤离装置并屏气5 s 12 2 41.4 6.9
E14 屏气后,未做到缓慢呼气 0 0 0.0 0.0
E15 吸药结束后,未用卫生纸擦拭吸嘴 10 2 34.5 6.9
E16 吸药结束后,未将胶囊壳倒掉 2 0 6.9 0.0
E17 未关闭吸嘴和防尘帽 0 0 0.0 0.0
E18 未漱口2或3次 10 9 34.5 31.0
E19 未吐掉漱口水 3 1 10.3 3.4
E20 不清楚“该药可能对青光眼、前列腺增生有影响” 11 6 37.9 20.7
合计 128 23 - -

表2 患者未正确使用吸入药物清单

Tab.2 Checklist of incorrect use of inhalation medication by the patients

3 讨论
3.1 吸入技术问题

本研究提示,近90%门诊哮喘和COPD患者在使用吸入药物时存在一个或多个错误,药师面对面教育和指导能显著改善患者吸入技术,从第一次教育到第二次随访,患者对不同装置使用的错误率均显著下降,无论患者以前是否使用过吸入装置,都受益于药师干预。本研究中发现的吸入剂常见使用错误与其他研究相似,如吸药前未呼气、未用力且深长的吸气以及吸入后未屏住呼吸等。在对吸入技术的详细评估中,也有其他错误,如未将瓶身直立(都保装置),未及时清理吸嘴以及在使用吸入剂后未及时漱口等,这些错误也被认为与吸入技术掌握不佳相关,因为它们可能对吸入药物的有效性和安全性产生影响。与其他研究类似,笔者发现,年龄、性别或受教育程度等人口统计数据与错误发生并无显著相关性,吸入技术的掌握也与吸入药物的数量无关。另外,无论哪种装置,患者存在问题最多的均是无法做到用力且深长地吸气,在吸药过程中,不用力及吸气较短是常见问题,药师在指导该项操作时,应注重对患者吸气力度及时间的教育,尽量鼓励患者操作到位,以促进药物有效吸入及药效发挥。

3.2 吸入技术评估表格的制定

诸多国外文献均使用吸入技术评估表格对患者进行吸入操作的评价及教育,比较一致的研究结果是患者的吸入技术掌握不佳。由于不同的吸入装置存在不同的操作要点,SRIRAM等[9]设计了都保装置、定量吸入器、干粉吸入器、准纳器这四种装置的操作评估表格,每个装置设置了10条患者可能出现的操作错误,用以评价患者的吸入操作,研究发现,用药依从性差和吸入操作不正确在COPD患者中很常见。

通过查阅文献并结合工作经验,笔者自制了信必可都保装置与噻托溴铵干粉吸入器的吸入技术操作清单,每种装置设置了20条目的操作细则及注意事项,这些细致的操作要点有助于患者正确掌握操作技巧,使药物充分利用,用以评估患者吸入技术。为避免患者发生吸入操作错误,药师按照操作清单对患者进行面对面干预,药师干预包括循序渐进的示范正确的吸入技术、口头指导和实际操作。这些教育手段在诸多研究中已被证实有效,可以显著提升患者吸入技术。

本研究结果提示,药师与患者面对面交流教育对患者掌握吸入技术有积极作用,改善了患者用药依从性和生活质量,正确使用吸入装置对患者控制病情有重要意义,也提示药师在呼吸系统慢性病管理中有重要作用。

慢性呼吸系统疾病控制率低、患者依从性差与患者不能正确操作吸入装置密切相关,今后笔者将进一步探讨吸入技术评估频率、持续时间以及慢病患者管理成效等,进一步研究药师干预对患者用药依从性、患者健康生活质量以及成本效益分析等,探索可行的药师参与慢性病管理策略,推动药师参与慢性病管理服务并提高管理的科学化程度。

The authors have declared that no competing interests exist.

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The correct use of inhalation devices is an inclusion criterion for all studies comparing inhaled treatments. In real life, however, patients may make many errors with their usual inhalation device, which may negate the benefits observed in clinical trials. Our study was undertaken to compare inhalation device handling in real life. A total of 3811 patients treated for at least 1 month with an inhalation device (Aerolizer, Autohaler, Diskus, pressurized metered dose inhaler (pMDI), or Turbuhaler) were included in this observational study performed in primary care in France between February 1st and July 14th, 2002. General practitioners had to assess patient handling of their usual inhaler device with the help of a checklist established for each inhaler model, from the package leaflet. Seventy-six percent of patients made at least one error with pMDI compared to 49-55% with breath-actuated inhalers. Errors compromising treatment efficacy were made by 11-12% of patients treated with Aerolizer, Autohaler, or Diskus compared to 28% and 32% of patients treated with pMDI and Turbuhaler, respectively. Overestimation of good inhalation by general practitioners was maximal for Turbuhaler (24%), and lowest for Autohaler and pMDI (6%). Ninety percent of general practitioners felt that participation in the study would improve error detection. These results suggest that there are differences in the handling of inhaler devices in real life in primary care that are not taken into account in controlled studies. There is a need for continued education of prescribers and users in the proper use of these devices to improve treatment efficacy.
DOI:10.1089/089426803769017613      PMID:14572322      URL    
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[4] FINK J B,RUBIN B K.Problems with inhaler use:a call for improved clinician and patient education[J].Respir Care,2005,50(10):1360-1374.
Patient education is a critical factor in the use and misuse of medication inhalers. Inhalers represent advanced technology that is considered so easy to use that many patients and clinicians do not receive adequate training in their use. Between 28% and 68% of patients do not use metered-dose inhalers or powder inhalers well enough to benefit from the prescribed medication, and 39-67% of nurses, doctors, and respiratory therapists are unable to adequately describe or perform critical steps for using inhalers. Of an estimated 25 billion dollars spent for inhalers annually, 5-7 billion dollars is wasted because of inhaler misuse. Reimbursement and teaching strategies to improve patient education could substantially reduce these wasted resources. Problems with inhaler use, the cost of inhalers, and myths associated with inhalers are reviewed, with recommendations for strategies and techniques to better educate patients in inhaler use.
PMID:16185371      URL    
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[5] HAMMERLEIN A,MULLER U,SCHULZ M.Pharmacist-led intervention study to improve inhalation technique in asthma and COPD patients[J].J Eval Clin Pract,2011,17(1):61-70.
Abstract Rational and aims68 Inhaled therapy is the mainstay of treatment in patients with asthma and chronic obstructive pulmonary disease (COPD). For effectiveness of pharmacotherapy, correct use of medication is required. The aims of this study were to survey the quality of inhalation technique in patients and to determine the effect of a single intervention in community pharmacies by means of standardized procedures. Methods68 A total of 757 patients with asthma or COPD were randomly selected by 55 community pharmacies. At baseline, patients were interviewed and their inhalation technique was assessed with a 21-items checklist. Any error was recorded and, if necessary, patients were instructed in the proper use of their device. After 4–6 weeks, demonstration of inhalation technique was repeated in the community pharmacies and a pre–post comparison was performed. Results68 A total of 597 patients (78.9%) made at least one mistake in performing the inhalation technique at baseline. This number dropped to 214 (28.3%) from the first to the second appointment. All patients did benefit from the pharmacists' intervention regardless of their former training experiences. Conclusions68 Inhalation technique of asthma and COPD patients is poor. In daily practice, community pharmacy-based pharmacists are well suited to significantly supplement doctor-based education in inhalation technique.
DOI:10.1111/j.1365-2753.2010.01369.x      PMID:20807295      Magsci     URL    
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[6] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013年修订版)[J].中华结核和呼吸杂志,2013,36(4):1-10.
正慢性阻塞性肺疾病(chronic obstructive pulmonary disease,简称慢阻肺)是一种严重危害人类健康的常见病、多发病,严重影响患者的生命质量,病死率较高,并给患者及其家庭以及社会带来沉重的经济负担。我国对7个地区20 245名成年人进行调查,结果显示40岁以上人群中慢阻肺的
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[7] 中华医学会呼吸病学分会哮喘学组.支气管哮喘诊治指南(2016年版)[J].中华结核和呼吸杂志,2016,39(9):1-24.
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[8] 吴秋惠,张桂凡,杨凡,.药师指导正确使用吸入剂对提高哮喘治疗的作用[J].药学与临床研究,2016,24(1):81-82.
调查发现门诊哮喘患者经药师用药教育后坚持用药的比率得到提高(P<0.001),但随着时间延长,患者自行停药的比率也在增加。药师根据患者停药原因(对不良反应的顾虑、症状好转松懈、疗效不佳、经济原因等)改进用药教育的内容与工作方式,使患者持续获益。
Magsci     URL    
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[9] SRIRAM K B,PERCIVAL M.Suboptimal inhaler medication adherence and incorrect technique are common among chronic obstructive pulmonary disease patients[J].Chron Respir Dis,2016,22(5):13-22.
Abstract Patients with chronic obstructive pulmonary disease (COPD) are routinely prescribed one or more inhaled medications. Adherence to inhaler medications and correct inhaler device technique are crucial to successful COPD management. The goals of this study were to estimate adherence and inhaler technique in a cohort of COPD patients. This was an observational study conducted on a sample of 150 COPD patients. Medication adherence was assessed using the Medication Adherence Report Scale (MARS). Inhaler technique was assessed using standardized checklists. Clinical data were collected using a proforma. Of the 150 patients (mean age 70.3 years, 52% male), 58% reported suboptimal adherence (MARS 24). High adherence to therapy (MARS = 25) was associated with older age (p = 0.001), but not any of the other studied variables. Medication non-adherence was not associated with COPD exacerbations. Errors (1) in inhaler technique were common across all of the types of inhaler devices reportedly used by patients, with the highest proportion of errors among Turbuhaler users (83%) and the least proportion of errors among Handihaler users (50%). No clinical variables were associated with errors in inhaler technique. Suboptimal adherence and errors in inhaler technique are common among COPD patients. No clinical variables to assist in the prediction of medication non-adherence and poor inhaler technique were identifiable. Consequently, regular assessment of medication adherence and inhaler technique should be incorporated into routine clinical practice to facilitate improved health outcomes among patients with COPD. The Author(s) 2015.
DOI:10.1177/1479972315606313      PMID:26396159      URL    
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关键词(key words)
哮喘
肺疾病
阻塞性
慢性
药师
吸入技术

Asthma
Pulmonary disease
obstructive
chronic
Pharmacist
Inhalation technique

作者
吴秋惠
张桂凡
张晶晶
葛卫红

WU Qiuhui
ZHANG Guifan
ZHANG Jingjing
GE Weihong