中图分类号:
R979.5
文献标识码:
A
文章编号:
1004-0781(2019)05-0614-09
摘要:
目的 利用可视化分析软件,对带状疱疹疫苗的研究现状、研究热点、发展趋势等进行客观全面地展示与分析,为带状疱疹的研究提供指导与参考。方法 以Web of Science 数据库为检索对象,纳入1980—2017年发表的与带状疱疹疫苗研究相关的文献,应用CiteSpace 5.2.R2版软件对作者、机构、国家、关键词、被引文献等进行可视化分析。结果 最终纳入2155篇符合要求的文章,发文量逐年增加,国际上对于带状疱疹疫苗的研究不断热化,美国的发文量最多,美国疾病预防控制中心、美国科罗拉多大学、美国斯坦福大学、美国哥伦比亚大学等机构所发表的文章居前,日本、欧洲也在该领域有比较深入的研究,各个作者、机构之间的合作较为紧密。结论 带状疱疹疫苗的研究仍处于新兴阶段,具有很强的发展潜力;美国、欧洲、日本对带状疱疹的研究处于世界领先水平;中国在带状疱疹疫苗领域的研究与国际同行相比存在很大的差距。
关键词:
疫苗
;
带状疱疹
;
CiteSpace软件
;
可视化分析
;
Web of Science
Abstract:
Objective To conduct an objective and comprehensive analysis of the international research status, research hotspots and development trends of herpes zoster vaccine based on visual analysis software, and provide useful guidance and reference for the research of herpes zoster. Methods The Web of Science database was used as the search object, and the articles related to the herpes zoster vaccine published from 1980 to 2017 were included. Visualizing analysis of the authors, institutions, countries, key words and cited documents was conducted based on CiteSpace 5.2.R2. Results A total of 2155 articles were eventually included, and the number of a publication increased year by year. The international research on the herpes zoster vaccine continues to heat up. The USA has the largest number of publications. The leading institutions were Center for Disease Control and Prevention (USA), the University of Colorado, Stanford University, and Columbia University. Japan and Europe also have conducted in-depth research in this field. The leading authors and agencies have a relatively close relationship. Conclusion The study of herpes zoster vaccine is still under development, which has strong potential. The researches on herpes zoster in USA, Europe, and Japan ranks among the top in the world;China still lags behind its international peers.
Key words:
Herpes zoster
;
vaccine
;
CiteSpace
;
Visualization analysis
;
Web of Science
本研究将应用美国德雷塞尔大学学者陈超美博士开发的科学文献可视化分析的软件CiteSpace 5.2.R2[9],以科学引文索引(Science Citation Index,SCI)数据库Web of Science 平台为资料来源,绘制相关的可视化图谱,对带状疱疹疫苗在国际上的研究现状、研究热点、发展趋势等进行客观全面地展示与分析,为带状疱疹的研究提供指导与参考[10,11]。
1 资料与方法
1.1 资料来源
以SCI数据库Web of Science 平台为资料来源,检索策略为:TS=(Herpes Zoster OR Varicella Zoster Virus OR VZV) AND TS=Vaccine AND PY=(1980-2017)。纳入与带状疱疹疫苗相关的基础研究 、临床研究及综述报道,包括期刊文献(article)、综述(review)、会议论文(proceedings paper)。排除新闻、信件,以及重复发表的、与研究无关的文章。最终纳入2155篇符合要求的文章。
1980—2017年间,在Web of Science数据库中检索并筛选得到2155 篇符合要求的文章,年度发文量见图1。从图1看出,发文量呈现逐年上升趋势,尤其是在2006年默沙东公司研制的Zostavax[12,13]被美国食品药品管理局(FDA)批准上市之后,发文量大幅增加,反映出国际上对带状疱疹疫苗的研究热度在不断攀升。
Fig.3
Cluster view of the authors studing herpes zoster vaccine from 1980 to 2017
表2
Tab.2
表2
表2
1980一2017年带状疱疹疫苗研究文献作者、关键词聚类分析
Tab.2
Cluster analysis on the authors studing herpes zoster vaccine from 1980 to 2017
聚类ID
聚类标签
代表作者
研究内容
0
zoster vaccine
LEVIN M J、CHAN
带状疱疹疫苗的研
ISF等
发
2
adult vaccination
SCHMID D S、
疫苗的应用
BREUER J等
3
cell-mediated
YAMANISHI K、
带状疱疹疫苗的作
immunity
WUTZLER P等
机制用
4
paralysis
GERSHON A A、
带状疱疹疫苗特殊
ARVIN A M等
人群应用
7
galy
BEUTEL P、
带状疱疹疫苗的经
SIEDLER A等
济性研究
10
adult vaccination
BRIDGES C B、
对各种疫苗的研究
DEAN A K等
12
seroepidemiology
SAUERBREI A、
病毒的流行病学研
JONE L等
究
14
efficacy
Brisson M、
带状疱疹疫苗有效
Edmunds WJ等
性、安全性研究
18
disease burden
BOLLAERTS K、
带状疱疹的社会学
BONHOEFFER J
研究
等
表2
1980一2017年带状疱疹疫苗研究文献作者、关键词聚类分析
Tab.2
Cluster analysis on the authors studing herpes zoster vaccine from 1980 to 2017
利用CiteSpace突发性检测功能,得到作者在不同年份的发文量突变情况,结果见图4。可以看出最早进行带状疫苗研究的作者是ARVIN A M[14],发文量最多的作者GERSHON[2]在1996—2012年间出现了突出的增长,2014年之后,ACOSTA C I与KAWAII K的发文量突增,而其他作者出现明显的下降趋势。
Fig.6
Geographic visual images of the publication on herpes zoster vaccine from 1980 to 2017 (Centers from left to right are:United States American, Europe, Japan)
Fig.7
Co-occurrence map of key words in the publications on herpes zoster vaccine from 1980 to 2017
2.6 文献共被引分析
利用Web of Science数据库自带的分析检索功能,获得被引频次最高的10篇文章,见表5。从中可以看出,OXMAN等2005年发表在《新英格兰医学杂志》上的文章A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults被引次数最多,一共被引用了1173次,文章通过一项随机、双盲、安慰药对照、由28 546例60岁及以上中老年人参与的临床试验,证实了带状疱疹减毒疫苗可以有效降低带状疱疹和PHN的发病率[15]。被引次数前十的文章包括VZV、水痘、带状疱疹、流行病学、免疫学等多个方面。
表5
Tab.5
表5
表5
1980一2017年带状疱疹疫苗研究文章中被引频次前十的文章
Tab.5
Top ten cited articles in the publications on herpes zoster vaccine from 1980 to 2017
排名
题名
作者
出版物及年、卷、期、页码
被引频次
1
A vaccine to prevent herpes zoster and
OXMAN M N,LEVIN M J,JOHNSON
The New England Journal of Medicine,
1173
postherpetic neuralgia in older adults
G R,et al.
2015,352(22):2271-2284.
2
Correlates of Protection Induced by
PLOTKIN S A
Clinical and Vaccine Immunology,
453
Vaccination
2010,17(7):1055-1065.
3
Duration of humoral immunity to
AMANNA I J,CARLSON N E,SLIFKA
The New England Journal of Medicine,
437
common viral and vaccine antigens
M K
2007,357(19):1903-1915.
4
A population-based study of the
YAWN B P,SADDIER P,WOLLAN
Mayo Clinic Proceedings,
363
incidence and complication rates of
P C,et al
2007,82(11):1341.
herpes zoster before zoster vaccine
introduction
5
Review of cytomegalovirus
CANNON M J,SCHMID D S,HYDE
Reviews in Medical Virology,2010,20
343
seroprevalence and demographic
T B
(4):202-213.
characteristics associated with
infection
6
Immunological mechanisms of
PULENDRAN B,AHMED R
Nature Immunology,2011,12(6):509.
312
vaccination
7
The Incidence of Zoster after
ASANO
The New England Journal of Medicine,
302
Immunization with Live Attenuated
1991,325(22):1545-1550.
Varicella Vaccine - A Study in
Children with Leukemia - NEJM
8
Varicella-zoster virus
ARVIN A M
Clinical Microbiology Reviews,1996,
299
9(3):361-381.
9
Varicella
HEININGER U,SEWARD J F
Lancet,2006,368(9544):1365-1376.
261
10
Epidemiology of varicella zoster virus
BRISSON M,EDMUNDS W J,LAW B,
Epidemiology & Infection,2001,
252
infection in Canada and the United
et al
127(2):305.
Kingdom
表5
1980一2017年带状疱疹疫苗研究文章中被引频次前十的文章
Tab.5
Top ten cited articles in the publications on herpes zoster vaccine from 1980 to 2017
Fig.10
Time view of co-citation articles on herpes zoster vaccine from 1980 to 2017
3 讨论
本研究从国际权威的科学引文索引数据库Web of Science收集带状疱疹疫苗相关的信息,采用科学文献可视化分析的软件CiteSpace进行可视化分析,对作者、机构、国家、关键词、被引文献等研究主体进行分析,有助于把握该领域研究的演变规律、前沿热点、发展趋势等。
从发文量来看,国际上对于带状疱疹疫苗的研究不断热化,随着Zostavax、Shingrix等带状疱疹疫苗的不断上市,带状疱疹疫苗市场将会不断被开拓,带状疱疹疫苗的研究热度将会有增无减。美国在带状疱疹疫苗的研究方面占据着核心主导地位,同时欧洲、日本也各自形成了自己的中心,三者在带状疱疹疫苗研究领域领先,中国由于尚未开展带状疱疹的研究调查和建立带状疱疹的检测系统,在带状疱疹疫苗研究上落后于美国、欧洲、日本,后期能否跟进需要众多学者和机构的共同努力,加强与国际高水平科研机构的合作交流。对于带状疱疹疫苗的研究,除了政府部门、大学之外,一些企业,例如美国默克公司、美国葛兰素史克公司等纷纷投入大量人力、物力、财力,说明带状疱疹疫苗领域的潜力。在这一领域,文章数量最多作者是GERSHON A A,而被引频次最高的文章是 OXMAN等2005年发表的文章,这些被引频次高的文章,一般都发表在The New England Journal of Medicine、Clinical and Vaccine Immunology、Lancet等水平极高、发表难度极大的核心期刊中。通过研究分析,未来几年带状疱疹疫苗领域的热点主要会集中在带状病毒疫苗的研发、临床研究及应用,带状疱疹的流行病学研究与防控,VZV的分子流行病学、基因组学研究。
本研究也存在一些局限性,仅对Web of Science数据库中的文献进行了分析,在数据信息的收集上会有所缺漏,会对研究结果产生一定影响,但并不影响对该领域的整体把握,其结论依旧具有很重要的指导意义。
GILDEND,MAHALINGAMR,NAGELM A,et al.Review:the neurobiology of varicella zoster virus infection[J].,2011,37(5):441-463.
D. Gilden, R. Mahalingam, M. A. Nagel, S. Pugazhenthi and R. J. Cohrs (2011) Neuropathology and Applied Neurobiology37, 441 463The neurobiology of varicella zoster virus infectionVaricella zoster virus (VZV) is a neurotropic herpesvirus that infects nearly all humans. Primary infection usually causes chickenpox (varicella), after which virus becomes latent in cranial nerve ganglia, dorsal root ganglia and autonomic ganglia along the entire neuraxis. Although VZV cannot be isolated from human ganglia, nucleic acid hybridization and, later, polymerase chain reaction proved that VZV is latent in ganglia. Declining VZV-specific host immunity decades after primary infection allows virus to reactivate spontaneously, resulting in shingles (zoster) characterized by pain and rash restricted to one to three dermatomes. Multiple other serious neurological and ocular disorders also result from VZV reactivation. This review summarizes the current state of knowledge of the clinical and pathological complications of neurological and ocular disease produced by VZV reactivation, molecular aspects of VZV latency, VZV virology and VZV-specific immunity, the role of apoptosis in VZV-induced cell death and the development of an animal model provided by simian varicella virus infection of monkeys.
KATZS L.Varicella and herpes zoster vaccines:WHO position paper,June 2014[J].,2014,89(25):265-287.
The article discusses the papers released by the World Health Organization (WHO) on varicella and herpes zoster vaccines as of June 2014. Topics discussed include use of vaccines in large-scale immunization programmes against the diseases, information to prevent the prevalence of disease caused by varicella and herpes zoster and its diagnosis and treatment. Also discusses the formulation of vaccines based on live attenuated varicella zoster virus for Oka strain.
SCHMIDT-CHANASITJ,SAUERBREIA.Evolution and world-wide distribution of varicella-zoster virus clades[J].,2011,11(1):1-10.
[本文引用:1]
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李杰,陈超美.[M].北京:首都经济贸易大学出版社,2006:1-244.
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[10]
SYNNESTVEDTM B,CHENC,HOLMESJ H.CiteSpace II:visualization and knowledge discovery in bibliographic databases[J].,2005:724-728.
This article presents a description and case study of CiteSpace II, a Java application which supports visual exploration with knowledge discovery in bibliographic databases. Highly cited and pivotal documents, areas of specialization within a knowledge domain, and emergence of research topics are visually mapped through a progressive knowledge domain visualization approach to detecting and visualizing trends and patterns in scientific literature. The test case in this study is progressive knowledge domain visualization of the field of medical informatics. Datasets based on publications from twelve journals in the medical informatics field covering the time period from 1964-2004 were extracted from PubMed and Web of Science (WOS) and developed as testbeds for evaluation of the CiteSpace system. Two resulting document-term co-citation and MeSH term co-occurrence visualizations are qualitatively evaluated for identification of pivotal documents, areas of specialization, and research trends. Practical applications in bio-medical research settings are discussed.
CHENC.CiteSpace II:detecting and visualizing emerging trends and transient patterns in scientific literature[J].,2009,57(3):359-377.
[本文引用:1]
[12]
SANFORDM,KEATINGG M.Zoster vaccine(Zostavax):a review of its use in preventing herpes zoster and postherpetic neuralgia in older adults[J].,2010,27(2):159-176.
ARVINA M,POLLARDR B,RASMUSSENL E,et al.Selective impairment of lymphocyte reactivity to varicella-zoster virus antigen among untreated patients with lymphoma[J].,1978,137(5):531-540.
Herpes zoster is a frequent complication of lymphoreticular malignancy. In this study two assays of in vitro cellular immune response to varicella-zoster virus (VZV) antigen, lymphocyte transformation and interferon production, were performed in normal subjects with recent and remote VZV infection. The responses of patients with lymphoma were measured before treatment and during long-term remission and then compared with those of normal subjects. Despite levels of antibody to VZV that were equivalent to those in normal subjects, 44% of the untreated lymphoma patients showed a lower transformation response to VZV antigen than the normal patients. Production of interferon in response to VZV antigen was absent in 32% of the untreated patients. In contrast, lymphocyte responses in untreated patients to herpes simplex virus antigen were within the range observed in a normal population. Interferon production by lymphocytes in response to cytomegalovirus antigen was also lower among untreated lymphoma patients than among normal patients, but lymphocyte transformation was not. Twenty-two percent of lymphoma patients in long-term remission continued to have diminished cellular immune responses to VZV antigen. Observations in these patient populations and in normal subjects with acute herpes zoster suggest that deficiencies in in vitro lymphocyte responses may correlate with increased susceptibility to clinical infection with VZV.
YUKIKOT,YOSHIYUKIM,MASAYUKIO,et al.Incidences of herpes zoster and postherpetic neuralgia in Japanese adults aged 50 years and older from a community-based prospective cohort study:the SHEZ study[J].,2015,25(10):617-625.
Many cross-sectional studies have examined the incidences of herpes zoster (HZ) and postherpetic neuralgia (PHN), but prospective studies in Japanese older adults are lacking. Therefore, we conducted a community-based prospective cohort study to determine the incidence in Japanese adults aged 50 years. We recruited 12 522 participants from Shozu County, Kagawa Prefecture, between December 2008 and November 2009 and followed participants for 3 years. When a subject presented with symptoms suggestive of HZ, they were examined at collaborating medical institutions and cooperated with onset and recovery surveys (eg, measurement of varicella zoster virus-specific immunity and a pain survey). The hazard ratios (HRs) of HZ and PHN according to sex and age were analyzed by Cox regression analysis with a significance level of 5%. The incidence of HZ was 10.9/1000 person-years (men: 8.5/1000 person-years; women: 12.8/1000 person-years) and was significantly higher in women than in men (HR 1.5; 95% confidence interval, 1.2 1.8). The incidence of PHN was 2.1/1000 person-years (men: 1.7/1000 person-years; women: 2.4/1000 person-years), with no significant sex differences. A total of 19% of HZ cases progressed to PHN; no sex-specific difference in the proportion of PHN cases was observed. We clarified the accurate incidences of HZ and PHN in a population of Japanese older adults. These incidences increased with age. HZ incidence was higher in women than in men, while PHN incidence did not differ markedly between the sexes.
LARUSSAP,LUNGUO,HARDYI,et al.Restriction frag-ment length polymorphism of polymerase chain reaction products from vaccine and wild-type varicella-zoster virus isolates[J].,1992,66(2):1016-1020.
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LOPAREVV N,GONZALEZA,DELEONCARNESM,et al.Global identification of three major genotypes of varicella-zoster virus:longitudinal clustering and strategies for genotyping[J].,2004,78(15):8349-8358.
By analysis of a single, variable, and short DNA sequence of 447 bp located within open reading frame 22 (ORF22), we discriminated three major varicella-zoster virus (VZV) genotypes. VZV isolates from all six inhabited continents that showed nearly complete homology to ORF22 of the European reference strain Dumas were assigned to the European (E) genotype. All Japanese isolates, defined as the Japanese (J) genotype, were identical in the respective genomic region and proved the most divergent from the E strains, carrying four distinct variations. The remaining isolates carried a combination of E- and J-specific variations in the target sequence and thus were collectively termed the mosaic (M) genotype. Three hundred twenty-six isolates collected in 27 countries were genotyped. A distinctive longitudinal distribution of VZV genotypes supports this approach. Among 111 isolates collected from European patients, 96.4% were genotype E. Consistent with this observation, approximately 80% of the VZV strains from the United States were also genotype E. Similarly, genotype E viruses were dominant in the Asian part of Russia and in eastern Australia. M genotype viruses were strongly dominant in tropical regions of Africa, Indochina, and Central America, and they were common in western Australia. However, genotype M viruses were also identified as a minority in several countries worldwide. Two major intertypic variations of genotype M strains were identified, suggesting that the M genotype can be further differentiated into subgenotypes. These data highlight the direction for future VZV genotyping efforts. This approach provides the first simple genotyping method for VZV strains in clinical samples.
... 利用CiteSpace突发性检测功能,得到作者在不同年份的发文量突变情况,结果见图4.可以看出最早进行带状疫苗研究的作者是ARVIN A M[14],发文量最多的作者GERSHON[2]在1996—2012年间出现了突出的增长,2014年之后,ACOSTA C I与KAWAII K的发文量突增,而其他作者出现明显的下降趋势. ...
... 本研究将应用美国德雷塞尔大学学者陈超美博士开发的科学文献可视化分析的软件CiteSpace 5.2.R2[9],以科学引文索引(Science Citation Index,SCI)数据库Web of Science 平台为资料来源,绘制相关的可视化图谱,对带状疱疹疫苗在国际上的研究现状、研究热点、发展趋势等进行客观全面地展示与分析,为带状疱疹的研究提供指导与参考[10,11]. ...
CiteSpace II:visualization and knowledge discovery in bibliographic databases
1
2005
... 本研究将应用美国德雷塞尔大学学者陈超美博士开发的科学文献可视化分析的软件CiteSpace 5.2.R2[9],以科学引文索引(Science Citation Index,SCI)数据库Web of Science 平台为资料来源,绘制相关的可视化图谱,对带状疱疹疫苗在国际上的研究现状、研究热点、发展趋势等进行客观全面地展示与分析,为带状疱疹的研究提供指导与参考[10,11]. ...
CiteSpace II:detecting and visualizing emerging trends and transient patterns in scientific literature
1
2009
... 本研究将应用美国德雷塞尔大学学者陈超美博士开发的科学文献可视化分析的软件CiteSpace 5.2.R2[9],以科学引文索引(Science Citation Index,SCI)数据库Web of Science 平台为资料来源,绘制相关的可视化图谱,对带状疱疹疫苗在国际上的研究现状、研究热点、发展趋势等进行客观全面地展示与分析,为带状疱疹的研究提供指导与参考[10,11]. ...
Zoster vaccine(Zostavax):a review of its use in preventing herpes zoster and postherpetic neuralgia in older adults
1
2010
... 1980—2017年间,在Web of Science数据库中检索并筛选得到2155 篇符合要求的文章,年度发文量见图1.从图1看出,发文量呈现逐年上升趋势,尤其是在2006年默沙东公司研制的Zostavax[12,13]被美国食品药品管理局(FDA)批准上市之后,发文量大幅增加,反映出国际上对带状疱疹疫苗的研究热度在不断攀升. ...
INC.Zoster vaccine(Zostavax?)
1
2009
... 1980—2017年间,在Web of Science数据库中检索并筛选得到2155 篇符合要求的文章,年度发文量见图1.从图1看出,发文量呈现逐年上升趋势,尤其是在2006年默沙东公司研制的Zostavax[12,13]被美国食品药品管理局(FDA)批准上市之后,发文量大幅增加,反映出国际上对带状疱疹疫苗的研究热度在不断攀升. ...
Selective impairment of lymphocyte reactivity to varicella-zoster virus antigen among untreated patients with lymphoma
1
1978
... 利用CiteSpace突发性检测功能,得到作者在不同年份的发文量突变情况,结果见图4.可以看出最早进行带状疫苗研究的作者是ARVIN A M[14],发文量最多的作者GERSHON[2]在1996—2012年间出现了突出的增长,2014年之后,ACOSTA C I与KAWAII K的发文量突增,而其他作者出现明显的下降趋势. ...
A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults
... 利用Web of Science数据库自带的分析检索功能,获得被引频次最高的10篇文章,见表5.从中可以看出,OXMAN等2005年发表在《新英格兰医学杂志》上的文章A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults被引次数最多,一共被引用了1173次,文章通过一项随机、双盲、安慰药对照、由28 546例60岁及以上中老年人参与的临床试验,证实了带状疱疹减毒疫苗可以有效降低带状疱疹和PHN的发病率[15].被引次数前十的文章包括VZV、水痘、带状疱疹、流行病学、免疫学等多个方面. ...
Incidences of herpes zoster and postherpetic neuralgia in Japanese adults aged 50 years and older from a community-based prospective cohort study:the SHEZ study