甲磺酸伊马替尼片在中国健康受试者中的餐后生物等效性研究

苏钰文,徐玲燕,徐延,郑枫,肖大伟

Bioequivalence Study of Imatinib Mesylate Tablets in Post-prandial Conditions in Healthy Chinese Volunteers

Yuwen SU,Lingyan XU,Yan XU,Feng ZHENG,Dawei XIAO

伊马替尼UPLC-MS/MS色谱图 A.空白血浆;B.流动相中加入伊马替尼和内标伊马替尼-d8溶液;C.定量下限样品;D.3号受试者给药400 mg甲磺酸伊马替尼片后36 h样品。

Typical UPLC-MS/MS chromatograms of imatinib A.blank plasma;B.mobile phase spiked with imatinib and internal standard(IS);C.sample of lower limit of quantitation;D.sample at 36 h after oral administration of 400 mg imatinib mesylate tablet.