GJ-4对帕金森病模型小鼠的保护作用及其机制*

袁方玉,盛婵娟,鞠程,李方园,臧彩霞,尚俊美,刘慧,鲍秀琦,张丹

Protective Effect and Mechanism of GJ-4 on Mice of Parkinson's Disease

Fangyu YUAN,Chanjuan SHENG,Cheng JU,Fangyuan LI,Caixia ZANG,Junmei SHANG,Hui LIU,Xiuqi BAO,Dan ZHANG

图3 3组小鼠中脑炎症因子检测结果 A.Western blot检测小鼠中脑 iNOS表达(n=5);B.qPCR检测小鼠中脑TNF-α mRNA表达(n=4);C.qPCR检测小鼠中脑IL-1β mRNA表达(n=4);①与空白对照组比较,t=2.309~2.956,P<0.05;②与模型对照组比较,t=2.427~2.877,P<0.05。

Fig.3 Detection results of inflammatory cytokine in mice midbrains of three groups A.iNOS expression in mice midbrain detected by Western blot(n=5);B.mRNA expression of TNF-α in mice midbrain detected by qPCR (n=4);C.mRNA expression of IL-1β in mice midbrain detected by qPCR (n=4);①Compared with blank control group,t=2.309-2.956,P<0.05;②Compared with model control group,t=2.427-2.877,P<0.05.