纳米载药系统调控肿瘤相关巨噬细胞抗肿瘤研究进展

韦朝晗,丁梓荞,张晓琼,雍土莹,甘璐,杨祥良

Research Progress on Nano Drug Delivery System Regulating Tumor-associated Macrophages for Cancer Therapy

Zhaohan WEI,Ziqiao DING,Xiaoqiong ZHANG,Tuying YONG,Lu GAN,Xiangliang YANG

图5 TAMs作为纳米药物的载体和药物“仓库” A.Anionic-AuNRs@RAW 有效靶向至肿瘤组织乏氧区域,用于肿瘤光声成像和光热治疗[64];B.LD-MDS 可有效靶向至肿瘤肺部转移病灶,并形成DENs,抑制肿瘤肺转移[65];C.TAMs作为载有 Pt 前药 PLGA-PEG 高分子纳米粒的“仓库”,向临近肿瘤细胞持续释放药物[66]。

Fig.5 TAMs act as delivery Vehicles and depots of nanomedicines A.Anionic-AuNRs@RAW is efficiently targeted to tumor hypoxic regions for tumor photoacoustic imaging and photothermal therapy[64];B.LD-MDS can effectively target metastatic lesions in lungs and transform into DNEs for antimetastasis therapy[65];C.TAMs serve as a local depot of Pt pro-drug encapsuled PLGA-PEG nanoparticles from which Pt payload gradually released to neighbouring tumour cells[66].