纳米疫苗的发展与应用*

吕蔚林,陈朝霞,雍土莹,甘璐,杨祥良

Developments and Applications of Nano-vaccines

Weilin LYU,Zhaoxia CHEN,Tuying YONG,Lu GAN,Xiangliang YANG

图1 脂质纳米疫苗的制备与应用 A.PEG修饰的载mRNA脂质纳米颗粒结构示意图[3];B.在血清白蛋白存在的情况下,纳米粒结构和脂质-PEG分离的示意图[14];C.膜锚定脂蛋白链接抗体至脂质纳米颗粒表面示意图[8];D.ICMVs合成示意图及电镜图;E.ICMVs与其他结构脂质体抗原释放速率对比[9]。

Fig.1 Preparation and application of lipid nano-vaccines A.Schematic diagram of the structure of PEG-modified mRNA-loaded lipid nanoparticles[3];B.Schematic diagram of nanoparticle structure and lipid-PEG separation in the presence of serum albumin[14];C.schematic diagram of membrane-anchored lipo-protein linking antibodies to the surface of lipid nanoparticles[8];D.Schematic diagram of ICMVs synthesis and electron microscope image;E.Comparison of antigens release rate between ICMVs and other liposome structures[9].