高效液相色谱法测定曲伏噻吗滴眼液中马来酸噻吗洛尔及其有关物质含量

费路华,费瀚雨,吴娟

Determination of Timolol Maleate and Related Substances in Travoprost and Timolol Maleate Eye Drops by HPLC

Luhua FEI,Hanyu FEI,Juan WU

图2 降解实验HPLC色谱图 A.未破坏样品;B.酸破坏;C.碱破坏;D.热破坏;E.氧化破坏;F.光破坏;G.供试品溶液;H.空白辅料溶液;1.马来酸;2.杂质G;3.杂质D;4.杂质E;5.杂质F;6.杂质B;7.噻吗洛尔;8.杂质C。

Fig.2 HPLC chromatograms in degradation experiment A.normal sample;B.destroyed by acid;C.destroyed by alkali;D.destroyed by heat;E.destroyed by oxidation;F.destroyed by light;G.test solution;H.blank auxiliary material solution;1.maleic acid;2.impurity G;3.impurity D;4.impurity E;5.impurity F;6.impurity B;7.timolol;8.impurity C.