3个小分子拮抗剂与C-X-C型趋化因子受体4的构效关系*

王坤,何璐,廖欣宇,王旭,施政良,杨光,李彦林

Structure-activity Relationships Between Three Small-molecule Antagonists and C-X-C Chemokine Receptor 4

Kun WANG,Lu HE,Xinyu LIAO,Xu WANG,Zhengliang SHI,Guang YANG,Yanlin LI

图2 T140与CXCR4计算机3D模拟图(A)和2D模拟图(a) 蓝色分子为配体T140,虚体为受体CXCR4螺旋结构,编号代表氨基酸位置,其余关于本图的详细描述请参照图1。

Fig.2 Computer 3D (A)and 2D (a) simulation diagram between T140 and CXCR4 Blue molecule is ligand T140;virtual body is helical structure of receptor CXCR4;number represents the amino acid position;other detailed description of this figure please refer to Fig.1.