芦丁通过抑制JAK2-STAT3信号通路活性改善MRL/lpr狼疮小鼠的肾损伤*

李海东,王旭,王艺睿,冯桂泽,倪佳慧,游艳,沈晓燕

Protective Effect of Rutin on Renal Lesion of MRL/lpr Mice Through Inhibiting JAK2-STAT3 Signaling Pathway

Haidong LI,Xu WANG,Yirui WANG,Guize FENG,Jiahui NI,Yan YOU,Xiaoyan SHEN

图5 6组小鼠肾组织病理图(×200,$\bar{x}±s$,n=10) A.正常对照组;B.模型对照组;C.醋酸泼尼松组;D.芦丁小剂量组;E.芦丁中剂量组;F.芦丁大剂量组。①与正常对照组比较,t=18.62,P<0.01;②与模型对照组比较,t=2.990,P<0.05;③与模型对照组比较,t=5.820~6.212,P<0.01;④与芦丁小剂量组比较,t=2.788,P<0.05。

Fig.5 Pathological picture of renal tissue in six groups of mice(×200,$\bar{x}±s$,n=10) A.normal control group;B.model control group;C.prednisone acetate group;D.low-dose of rutin group;E.medium-dose of rutin group;F.high-dose of rutin group.①Compared with normal control group,t=18.62,P<0.01;②Compared with model control group,t=2.990,P<0.05;③Compared with model control group,t=5.820-6.212,P<0.01;④Compared with low-dose of rutin group,t=2.788,P<0.05.